Familial osteopetrosis in Agouti paca: report of nine cases

Abstract

Nine cases of familial osteopetrosis were studied in Agouti paca rodents maintained in captivity. Animals were distributed in three groups depending on the severity of their skeletal lesions. Based upon clinical, radiological, and microscopic findings, it was concluded that one animal had level I lesions, three animals had level II lesions, and five animals had level III osteopetrosis and osteonecrosis. Throughout the entire axial and appendicular skeleton, there was an increased amount of both trabecular and cortical bone tissue. All analyzed bones showed thickened cortex and reduced medullary canals. Bone trabeculae were thick and confluent. Cortex showed a narrowing of Haversian canals. Numerous cementing lines resulted in typical mosaic patterns. Osteocytes were pycnotic. Osteonecrosis was characterized by the disappearance of osteocytes and bone matrix decomposition.Keywords: Agouti paca, familial disease, osteonecrosis, osteopetrosis, skeleton RESUMO Descreveram-se nove casos de osteopetrose familiar em

Osteopetrosis in obese female rats is site‐specifically inhibited by physical training

“…; Coutinho et al . ). Rogéria Serakides and Natalia de Melo Ocarino analysed our results based on the classical morphological characteristics and also on the morphometric results (in normal conditions, control animals have ∼40–50% trabecular bone) to draw conclusions about the bone characteristics.…”

“…In order to maintain isocalcaemic conditions, bone resorption is delayed by calcitonin, thus resulting in a greater quantity of bone (Coutinho et al . ). In our study, the obese rats exhibited a higher caloric intake compared with the control groups.…”

“…Osteopetrosis is an osteometabolic disease that is caused by a reduction of bone resorption or an increase of bone formation, and its occurrence often compromises the nutrition of osteocytes and consequently leads to the death of these cells (Coutinho et al 2008). Morphological characteristics are used to define ostepeotrosis.…”

“…Morphological characteristics are used to define ostepeotrosis. There is an increase in the amount of trabecular and cortical bone tissue, and the epiphyseal and metaphyseal trabeculae are thick, confluent and concentrically arranged, with osteonic configurations (Coutinho et al 2008). In addition, there are numerous cementing lines that result in mosaic patterns indicative of retarded osteocytic osteolysis (Sakagami et al 2005;Coutinho et al 2008).…”

“…There is an increase in the amount of trabecular and cortical bone tissue, and the epiphyseal and metaphyseal trabeculae are thick, confluent and concentrically arranged, with osteonic configurations (Coutinho et al 2008). In addition, there are numerous cementing lines that result in mosaic patterns indicative of retarded osteocytic osteolysis (Sakagami et al 2005;Coutinho et al 2008). Rogéria Serakides and Natalia de Melo Ocarino analysed our results based on the classical morphological characteristics and also on the morphometric results (in normal conditions, control animals have ß40-50% trabecular bone) to draw conclusions about the bone characteristics.…”