Eficácia da clorexidina-cetrimida na desinfecção ambiental contra Aspergillus spp.

Xavier, Melissa Orzechowski; Meinerz, Ana Raquel Mano; Cleff, Marlete Brum; Osório, L.G.; Schuch, Luiz Filipe Damé; Nobre, M.O.; Filho, Rodolfo Pinho Silva; Meireles, Mário Carlos Araújo

doi:10.1590/s0102-09352008000400015

Cited by 3 publications

(2 citation statements)

References 13 publications

(1 reference statement)

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“…and Aspergillus spp. has been described by other authors ( Xavier et al , 2007 ; Xavier et al , 2008 ; Medeiros et al , 2009 ). In agreement with these results, this study observed that sodium hypochlorite did not have a satisfactory action against the isolates tested, while chlorexidine-cetrimide showed efficacy against the same Aspergillus spp.…”

Section: Discussionsupporting

confidence: 63%

“…Research to determine the prevalent fungi of the Aspergillus genus in hospital environments has been developed, inasmuch as these are potential infection sources ( Morris et al , 2000 ; Vonberg and Gastmeier, 2006 ; Falvey and Streifel, 2007 ). However, studies in veterinary environments are still scarce ( Xavier et al , 2008 ; Mattei et al , 2011 ).…”

Section: Introductionmentioning

confidence: 99%

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In vitro activity of disinfectants against Aspergillus spp

Mattei¹,

Madrid²,

Santin³

et al. 2013

Braz. J. Microbiol.

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Fungi of the Aspergillus genus are widespread and contaminate the environment. Thousands of conidia are released from each phialide and dispersed in the air every day. These fungi are considered important mycose-causing agents in hospitals. Due to this, research to determine prevalent fungi from the Aspergillus genus in hospital environments, and an adequate disinfection program in these areas is are needed. This study evaluated the susceptibility of Aspergillus spp. isolated from a veterinary environment against four disinfectants. Successive dilutions of disinfectants (log2) were used according to CLSI M38-A2 microdilution technique adapted to chemical agents against 18 isolates of this genus. After 72 hours of incubation, the Minimum Inhibiting Concentration and Minimum Fungicidal Concentration capable of inhibiting 50% and 90% of the isolates were determined. Chlorexidine-cetrimine, benzalconium chloride and a chlorophenol derivative proved to be effective against all isolates with a lower MIC than that suggested by the manufacturer, except for the A. flavus strain. Sodium hypochlorite was ineffective against three A. fumigatus, three A. flavus and one A. niger isolate. These results demonstrated that all studied disinfectants were effective against environmental isolates, with the exception of sodium hypochlorite, which showed lower effectiveness.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

In vitro activity of disinfectants against Aspergillus spp

Mattei¹,

Madrid²,

Santin³

et al. 2013

Braz. J. Microbiol.

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Molecular epidemiology of aspergillosis in Magellanic penguins and susceptibility patterns of clinical isolates

et al. 2021

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Aspergillus section Fumigati is reported in up to 99% of aspergillosis cases in penguins. So far, no data regarding molecular epidemiology and azole resistance are available for A. fumigatus isolates collected from Magellanic penguins. The aim of this work was to perform molecular identification of Aspergillus section Fumigati at species level, to genotype those isolates using microsatellite markers, to evaluate the in vitro susceptibility patterns of A. fumigatus sensu stricto, and to characterize the cyp51A gene in clinical A. fumigatus strains isolated from Magellanic penguins with proven aspergillosis. All 34 isolates included in the study were identified as A. fumigatus sensu stricto. Analyzing the genetic diversity of the isolates of A. fumigatus sensu stricto, we identified two possible outbreaks in the rehabilitation center and we also observed the maintenance of clonal strains through the years. One A. fumigatus sensu stricto isolate was resistant to posaconazole, but the mutations found in the cyp51A gene of this isolate have not been described as conferring phenotypic resistance, suggesting that other mechanisms of resistance could be involved in the resistance of this isolate. With this study we were able to understand the molecular diversity of Aspergillus fumigatus isolates collected from Magellanic penguins, to characterize them and to associate them with the described global population of Aspergillus fumigatus.

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Incidence Density, Proportionate Mortality, and Risk Factors of Aspergillosis in Magellanic Penguins in a Rehabilitation Center From Brazil

Filho¹,

Xavier²,

Martins³

et al. 2015

Journal of Zoo and Wildlife Medicine

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Aspergillosis, an opportunistic mycosis caused by the Aspergillus genus, affects mainly the respiratory system and is considered one of the most significant causes of mortality in captive penguins. This study aimed to examine a 6-yr period of cases of aspergillosis in penguins at the Centro de Recuperação de Animais Marinhos (CRAM-FURG), Rio Grande, Brazil. A retrospective cohort study was conducted using the institution's records of penguins received from January 2004 to December 2009. Animals were categorized according to the outcome "aspergillosis," and analyzed by age group, sex, oil fouling, origin, prophylactic administration of itraconazole, period in captivity, body mass, hematocrit, and total plasma proteins. A total of 327 Magellanic penguins (Spheniscus magellanicus) was studied, 66 of which died of aspergillosis. Proportionate mortality by aspergillosis was 48.5%, and incidence density was 7.3 lethal aspergillosis cases per 100 penguins/mo. Approximately 75% of the aspergillosis cases occurred in penguins that had been transferred from other rehabilitation centers, and this was considered a significant risk factor for the disease. Significant differences were also observed between the groups in regard to the period of time spent in captivity until death, hematocrit and total plasma proteins upon admission to the center, and body mass gain during the period in captivity. The findings demonstrate the negative impacts of aspergillosis on the rehabilitation of Magellanic penguins, with a high incidence density and substantial mortality.

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Eficácia da clorexidina-cetrimida na desinfecção ambiental contra Aspergillus spp.

Cited by 3 publications

References 13 publications

In vitro activity of disinfectants against Aspergillus spp

In vitro activity of disinfectants against Aspergillus spp

Molecular epidemiology of aspergillosis in Magellanic penguins and susceptibility patterns of clinical isolates

Incidence Density, Proportionate Mortality, and Risk Factors of Aspergillosis in Magellanic Penguins in a Rehabilitation Center From Brazil

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