Eficácia das lactonas macrocíclicas sistêmicas (ivermectina e moxidectina) na terapia da demodicidose canina generalizada

Delayte, Ericka Homann; Otsuka, Mary; Larsson, Carlos Eduardo; Castro, R. C. C

doi:10.1590/s0102-09352006000100006

Cited by 21 publications

(34 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Efficacy of up to 89.7% has been reported when administered orally every day, but with treatment protocols of duration of up to 150 days (Ristic et al 1995, Delayte et al 2006). The present study evaluated the therapeutic potential of ivermectin applied using a pour-on formulation separately and in combination b dogs treated with pour-on 2.5% fluazuron and pour-on 0.5% ivermectin; c dogs treated with pour--on 0.5% ivermectin, d p>0.05; e 0 = no mites; f 1 = slight infestation; g 2 = mild infestation; h = moderate infestation; i 4 = severe infestation.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, premature termination may be the major cause of treatment failure (Gortel 2006). Differences in the duration of treatment protocols are reported by some authors, such as Delayte et al (2006), who obtained the first negative skin scraping result after 90 days of treatment and parasitological clearance after 130 days. Ristic et al (1995) obtained these same results at 45 and 70 days, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…The intensity of these alterations was classified as: (0) absent, (1) slight, (2) intermediate or (3) severe (Heine et al 2005, Delayte et al 2006). These parameters were used for clinical evaluation of the effectiveness of the proposed therapeutic protocols.…”

Section: Methodsmentioning

confidence: 99%

“…These parasites are transmitted from mother to offspring, which also inherit a specific cell-mediated condition of immunodeficiency (Heine et al 2005, Delayte et al 2006). …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical and parasitological evaluation of pour-on fluazuron and ivermectin for treating canine demodicosis

2014

View full text Add to dashboard Cite

RESUMO.-[Avaliação clínica e parasitológica do fluazuron e da ivermectina pour-on no tratamento da demodiciose canina.] O objetivo do presente estudo foi avaliar a eficácia do fluazuron e da ivermectina pour-on em diferentes protocolos terapêuticos no tratamento da demodiciose, através da quantificação de ácaros por raspados cutâneos e exames histológicos, além da avaliação dos cães. Foram avaliados 18 cães com raspados cutâneos positivos para o ácaro Demodex canis, divididos em três grupos. Todos os animais foram tratados a cada 14 dias, totalizando seis tratamentos em cada cão (Dias 0, 14, 28, 42, 56 e 70). No grupo 1 foi utilizado fluazuron 2,5% pour-on na dosagem de 20mg/kg; no grupo 2 foi empregado fluazuron 2,5% pour--on na dosagem de 20mg/kg associado a ivermectina 0,5% pour-on, na dosagem de 0,6mg/kg e, no grupo 3, somente ivermectina 0,5% pour-on 0,6mg/kg. The objective of the study was to evaluate the efficacy of pour-on formulations of fluazuron and ivermectin in different therapeutic protocols for treatment of demodicosis by means of quantifying mites with skin scraping, histological and clinical evaluation in dogs. Eighteen dogs with skin scrapings positive for Demodex canis were evaluated, divided into three groups. All the animals were treated every 14 days, completing 6 treatments for each animal (days 0, 14, 28, 42, 56 and 70). In group 1, pour-on 2.5% fluazuron was used at the dose of 20mg/kg; in the group 2 pour-on 2.5% fluazuron at a dose of 20 mg/kg in association with pour-on 0.5% ivermectin at the dose of 0.6mg/kg; and in group 3, pour-on 0.5% ivermectin alone was used, at the dose of 0.6mg/kg. The treatment was evaluated and monitored through skin scrapings and clinical follow-up of the lesions every 14 days for 84 days, and through histopathological examination at the end of each treatment protocol. The success rate was defined as the percentage of dogs in each group that had negative skin scrapings after the treatment: this was 16.67% for group 1, and 50% for groups 2 and 3. The reduction in mite counts reached effectiveness of 67.66%, 88.99% and 84.29% for groups 1, 2 and 3 respectively. The Wilcoxon test showed that there was a significant difference between the number of mites before and after treatment in groups 2 and 3. The histopathological examination revealed that only group 1 showed no significant difference in the intensity of infestation between days 0 and 84. Clinically, there was no significant difference between the evaluation before and after treatment in the three groups. Pour-on 2.5% fluazuron and pour-on 0.5% ivermectin were not effective for treating canine demodicosis, either in association or as single therapy, when applied every 14 days for a period of 70 days. Quantification of mites using skin scrapings and histological evaluation proved to be ineffective, either one as sole therapeutic evaluation parameters, for canine demodicosis.INDEX TERMS: Demodex canis, control, fluazuron, ivermectin, pour-on. 1095 Clinical and parasitological evaluation of pour-on fluazuro...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…These parasites are transmitted from mother to offspring, which also inherit a specific cell-mediated condition of immunodeficiency (Heine et al 2005, Delayte et al 2006). …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and parasitological evaluation of pour-on fluazuron and ivermectin for treating canine demodicosis

2014

View full text Add to dashboard Cite

show abstract

“…O uso de lactonas macrocíclicas em formulações injetá-veis, sendo administrada por via oral, foi relatada por Delayte et al (2006), em cães, para o tratamento de demodicidose. Os autores utilizaram a moxidectina injetável a 1% e a ivermectina, na apresentação de comprimidos, elaborados por empresa farmacêutica veterinária para o estudo.…”

Section: Quadro 2 Presença De Leporacarus Gibbus No Pelo Dos Coelhosunclassified

Eficácia da ivermectina oral no controle de Psoroptes ovis e Leporacarus gibbus em coelhos naturalmente infestados

et al. 2014

View full text Add to dashboard Cite

Pesq. Vet. Bras. 34(9):832-836, setembro 2014 832 RESUMO.-O objetivo do trabalho foi avaliar a eficácia da ivermectina administrada por via oral no controle de Psoroptes ovis e Leporacarus gibbus em coelhos naturalmente infestados. Foram selecionados 20 coelhos adultos, distribuídos na mesma proporção de ambos os sexos, em dois grupos experimentais, compondo dez animais por grupo. No grupo controle foi administrado o mesmo volume do tratamento de solução salina, enquanto o grupo tratado recebeu dose única de ivermectina oral (400 µg/Kg). O diagnóstico dos ácaros foi realizado com auxílio de microscópio estereoscópico após a devida coleta de material. Para P. ovis foi realizada através de coleta do cerúmen com auxílio de zaragatoas efetuadas nas orelhas e para por L. gibbus foi realizada coleta de pelos nas regiões do pescoço dorsal, The aim of the study was to evaluate the efficacy of oral ivermectin in the control of Psoroptes ovis and Leporacarus gibbus in naturally infested rabbits. Twenty adult rabbits were selected; they were distributed in two groups with equal proportions of both sexes, containing ten animals per group. In the control group the same volume of the treatment was administered of saline solution, meanwhile the treated group received a single dose of oral ivermectin (400µg/kg). The diagnosis of the mites was made with a stereoscopic microscope, after the proper collection of material. For P. ovis it was performed by collecting of ear wax with swabs and for L. gibbus it was performed by collecting hairs in the dorsal part of the neck, lumbar right, lumbar left, ventral side of the tail and ventral abdomen. The evaluation of the efficiency and the clinical evaluation of the lesions, measured in scores (grade 0 to 4) was made in days 0, +3, +7, +4, +21, +28, and +35, after treatment. An efficiency of 100% was observed for P. ovis following day +7, and for L. gibbus following day +14, remaining negative until the final day of the study. The score of lesions in the ears of the treated group regressed following day +14 and on day +21 all animals reached a score of 0. In the control group, two animals presented an increase in ear lesion score, one rabbit presented an increase from score 1 to 2, and the other rabbit, from score 3 to 4. No adverse reactions were observed in the treated animals. The single dose administration of oral ivermectin was successful in the control of P. ovis and L. gibbus in naturally infested rabbits. Eficácia da ivermectina oral no controle de

show abstract

The main factors influencing canine demodicosis treatment outcome and determination of optimal therapy

Arsenović¹,

Pezo

Vasić³

et al. 2015

Parasitol Res

View full text Add to dashboard Cite

The main idea of this research was to evaluate the efficacy of canine demodicosis conventional treatments using mathematical analyses. All available papers published between 1980 and 2014 were used in this study. One hundred six clinical trials enrolling 3414 cases of generalized demodicosis in dogs are studied. Dogs entered in the analysis were only the ones in which the disease occurred naturally, excluding the studies in which transplantation of Demodex canis mites was done from other animals. In conventional acaricide treatments, sorted according to active substances (moxidectin, amitraz, doramectin, ivermectin, and milbemycin oxime), the way of application (spot-on, dips, orally, or subcutaneous), concentration, and interval of application were used as input parameters in mathematical modeling. Data of interest were the treatment outcome, the number of dogs that went into remission, the number of animals not responding to treatment microscopically, the average duration of therapy, the follow-up period, the number of patients with disease recurrence, the number of adverse effects, and the number of animals with side effects. Dogs lost to follow-up or when the treatment was discontinued, due to various reasons not in connection with the therapy protocol, were not considered. Statistical and mathematical analyses were applied for prediction of the drugs' effectiveness. Developed mathematical models showed satisfactorily r (2), higher than 0.87. Good evidence for recommending the use of milbemycin oxime PO (0.5 mg/kg, daily) and moxidectin spot-on (Advocate®, Bayer) weekly is found. A bit less effective therapies were based on ivermectin PO (0.5 mg/kg, daily), moxidectin PO (0.35 mg/kg, daily), and amitraz dips (0.05 % solution, weekly), respectively. It is important to keep in mind that Advocate® is recommended by the manufacturer for use in milder cases.

show abstract

Eficácia das lactonas macrocíclicas sistêmicas (ivermectina e moxidectina) na terapia da demodicidose canina generalizada

Cited by 21 publications

References 6 publications

Clinical and parasitological evaluation of pour-on fluazuron and ivermectin for treating canine demodicosis

Clinical and parasitological evaluation of pour-on fluazuron and ivermectin for treating canine demodicosis

Eficácia da ivermectina oral no controle de Psoroptes ovis e Leporacarus gibbus em coelhos naturalmente infestados

The main factors influencing canine demodicosis treatment outcome and determination of optimal therapy

Contact Info

Product

Resources

About