Clinical and pathological study of feline mammary fibroadenomatous change associated with depot medroxyprogesterone acetate therapy

Feline Mammary Fibroepithelial Hyperplasia: A Clinical Approach

“…Despite that increase expression of PR has been found in the FEH lesions in comparison to normal diestrous mammary tissue samples, the blood levels for progesterone are usually within the normal levels for the species [6], although cats may present considerable variation in their progesterone blood levels [36]. This is suggestive that the disease would correspond to a disturbed, exaggerated response of the tissue to the circulating hormones.…”

“…Even so, seldom sporadic recovery is observed [6], and when described it usually take several weeks to months.…”

“…Feline mammary fibroepithelial hyperplasia occurs in intact queens of any age, in pregnant females and in female or male cats under progestin treatment [6][7][8]14]. It predominantly affects younger intact female cats, a segment of the population that also presents an increased ratio of spontaneous ovulation [15,16].…”

“…When exuberant it is often at the origin of the consultation [6][7][8][9]. Ulceration and abscessation of the mammary gland may occur due to gland enlargement and trauma, in chronic situations [9,10].…”

“…Recurrence of the situation, although possible, remains controversial [6,[11][12][13]. Nevertheless it is an important issue when discussing the therapeutic approach with owners.…”