Effects of desflurane, sevoflurane and isoflurane on pulmonary shunt in dogs during spontaneous ventilation

Nunes, Newton; Martins, S. E. C.; Santos, Paulo Sérgio Patto dos; Rezende, Marlis L.

doi:10.1590/s0102-09352003000200008

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…(26) Using 0.08 mL/kg, other authors (12) registered shunt values of up to 35%. Those authors also demonstrated the decrease in and the stabilization of PaO 2 in the first 30 min, this condition persisting for 4 h. Another group of authors (27) found lower, basal fractions of Qs/Qt than those found in our study, approximately 15-20%. The dose used in the present study (0.15 mL/kg) explains the high Qs/Qt levels found.…”

Section: Resultssupporting

confidence: 68%

Estabilidade do modelo animal de lesão pulmonar aguda induzida por ácido oleico

Gaio

Silva

Brito³

et al. 2009

J. bras. pneumol.

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Objective: To evaluate the stability of hemodynamic, respiratory and gas exchange variables in an animal model of oleic acid-induced acute lung injury. Methods: This was an experimental study involving 10 mongrel dogs. The variables were measured at baseline, as well as at 30, 60, 90 and 120 min after the administration of oleic acid. In order to analyze repeated measurements, linear and quadratic effects were tested. Mixed linear models with diversified variance and covariance structures were used, depending on the variable studied. Results: We found that mean arterial blood pressure stabilized at 30 min, as did heart rate, pulmonary arterial pressure and pulmonary capillary pressure at 60 min. Respiratory rate, tidal volume, minute volume and respiratory work stabilized at 30 min. Regarding gas exchange variables, PaO 2 , PaO 2 /FiO 2 ratio and pulmonary shunt fraction stabilized at 30 min. The remaining variables maintained a continuous rise or fall. Conclusions: This oleic acid-induced acute lung injury model is stable for some of the variables tested, although stabilization occurs at different times. The respiratory and gas exchange variables stabilized at 30 min, whereas the hemodynamic variables stabilized at 60 min. Keywords:Respiratory distress syndrome, adult; Models, animal; Statistical analysis. ResumoObjetivo: Avaliar a estabilidade das variáveis hemodinâmicas, da mecânica respiratória e de troca gasosa do modelo animal de lesão pulmonar aguda induzida por ácido oleico. Métodos: Trata-se de um estudo experimental no qual foram utilizados 10 cães de raça indeterminada. As variáveis foram aferidas inicialmente e em 30, 60, 90 e 120 min após a administração do ácido oleico. Para analisar as medidas repetidas, foram testados efeitos lineares e quadráticos e foram utilizados ajustes de modelos lineares mistos com estruturas de variâncias e covariâncias diversificadas, dependendo da variável analisada. Resultados: Observamos estabilidade da pressão arterial média aos 30 min, assim como da frequência cardíaca, da pressão arterial pulmonar e da pressão de capilar pulmonar aos 60 min. Frequência respiratória, volume corrente, volume minuto e trabalho respiratório estabilizaram aos 30 min. Quanto às variáveis de troca gasosa, PaO 2 , relação PaO 2 /FiO 2 e fração de shunt pulmonar estabilizaram-se aos 30 min. As demais variáveis mantiveram-se em ascensão ou queda contínuas. Conclusões: O modelo de lesão pulmonar aguda induzida por ácido oleico é estável para algumas das variáveis testadas; porém, a estabilização se dá em momentos diferentes. As variáveis da mecânica respiratória e de troca gasosa estabilizaram em 30 min, e as hemodinâmicas, em 60 min.Descritores: Síndrome do desconforto respiratório do adulto; Modelos animais; Análise estatística. *Study carried out in the

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Section: Resultssupporting

confidence: 68%

Estabilidade do modelo animal de lesão pulmonar aguda induzida por ácido oleico

Gaio

Silva

Brito³

et al. 2009

J. bras. pneumol.

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“…Por outro lado, deve-se salientar que os valores médios obtidos em M0, em ambos os grupos, apresentaram-se discretamente acima dos valores considerados normais, demostrando que o desfluorano promove alteração na PaCO 2 , produzindo médias elevadas, provavelmente devido a sua ação depressora sobre o sistema respiratório (CLARKE, 1999;SANTOS, 2000) e ao concomitante aumento do shunt pulmonar promovido pelo agente volátil (NUNES et al, 2003).…”

Section: Discussionunclassified

“…A administração do agente halogenado produz aumento da atividade simpática, a qual atinge o pico máximo decorridos 5 minutos de exposição ao fármaco (PACENTINE et al, 1995).…”

Section: Introductionunclassified

Hemogasometria e variáveis cardiopulmonares após administração do butorfanol em cães anestesiados pelo desfluorano sob ventilação espontânea

et al. 2007

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RESUMO Este experimento teve por objetivos avaliar as possíveis alterações cardiopulmonares e hemogasométricas decorrentes do uso do butorfanol em cães submetidos à anestesia pelo desfluorano sob ventilação espontânea. Para tal, foram utilizados vinte cães adultos, clinicamente saudáveis, pesando 12±3kg. Os animais foram distribuídos igualmente em dois grupos, GS e GB, e induzidos à anestesia com propofol (8,4±0, IV)

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Effect of Bronchoconstriction-induced Ventilation–Perfusion Mismatch on Uptake and Elimination of Isoflurane and Desflurane

Kretzschmar

Kozian

Baumgardner³

et al. 2017

Anesthesiology

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Background Increasing numbers of patients with obstructive lung diseases need anesthesia for surgery. These conditions are associated with pulmonary ventilation/perfusion (VA/Q) mismatch affecting kinetics of volatile anesthetics. Pure shunt might delay uptake of less soluble anesthetic agents but other forms of VA/Q scatter have not yet been examined. Volatile anesthetics with higher blood solubility would be less affected by VA/Q mismatch. We therefore compared uptake and elimination of higher soluble isoflurane and less soluble desflurane in a piglet model. Methods Juvenile piglets (26.7 ± 1.5 kg) received either isoflurane (n = 7) or desflurane (n = 7). Arterial and mixed venous blood samples were obtained during wash-in and wash-out of volatile anesthetics before and during bronchoconstriction by methacholine inhalation (100 μg/ml). Total uptake and elimination were calculated based on partial pressure measurements by micropore membrane inlet mass spectrometry and literature-derived partition coefficients and assumed end-expired to arterial gradients to be negligible. VA/Q distribution was assessed by the multiple inert gas elimination technique. Results Before methacholine inhalation, isoflurane arterial partial pressures reached 90% of final plateau within 16 min and decreased to 10% after 28 min. By methacholine nebulization, arterial uptake and elimination delayed to 35 and 44 min. Desflurane needed 4 min during wash-in and 6 min during wash-out, but with bronchoconstriction 90% of both uptake and elimination was reached within 15 min. Conclusions Inhaled methacholine induced bronchoconstriction and inhomogeneous VA/Q distribution. Solubility of inhalational anesthetics significantly influenced pharmacokinetics: higher soluble isoflurane is less affected than fairly insoluble desflurane, indicating different uptake and elimination during bronchoconstriction.

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Effects of desflurane, sevoflurane and isoflurane on pulmonary shunt in dogs during spontaneous ventilation

Cited by 4 publications

References 11 publications

Estabilidade do modelo animal de lesão pulmonar aguda induzida por ácido oleico

Estabilidade do modelo animal de lesão pulmonar aguda induzida por ácido oleico

Hemogasometria e variáveis cardiopulmonares após administração do butorfanol em cães anestesiados pelo desfluorano sob ventilação espontânea

Effect of Bronchoconstriction-induced Ventilation–Perfusion Mismatch on Uptake and Elimination of Isoflurane and Desflurane

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