Electrocardiographic evaluation of two anesthetic combinations in dogs

Tárraga, K.M.; Camacho, Aparecido Antônio

doi:10.1590/s0102-09352000000200009

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…In vivo guinea-pig models were studied over the years, both with conscious (Shiotani et al 2005) and anesthetized animals (Morissette et al 2013). This model is especially used to evaluate new drugs before they are allowed for commercialization, particularly those with high risk of arrhythmias and/or alterations of QT interval (Tárraga et al 2000). The QT interval measured in the ECG represents ventricular depolarization and repolarization (Tilley 1992).…”

Section: Introductionmentioning

confidence: 99%

Computerized electrocardiography in healthy conscious guinea pigs (Cavia porcellus)

et al. 2016

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The purpose of this study is to evaluate healthy conscious guinea pigs as a model for electrophysiology assessment and to describe normal electrocardiographic patterns in controlled laboratory environment, establishing the best QT formula for this method. Electrocardiographic recordings of fifty adult conscious guinea pigs were obtained using a computerized electrocardiography. The electrocardiographic measurements of three different tracings were analyzed. The results obtained established normal mean and range values for the parameters: heart rate, waves and intervals of P-QRS-T deflections, as well as the mean cardiac axis. Groups were separated by body weight: group 1 gathered animals with 500-699g and group 2 with animals 700-900g. No differences were found when measurements were compared between groups, showing no significant difference between weight/ body sizes to the electrocardiographic parameters (P<0.05). The mean corrected QT values (QTc) obtained using diverse formulae were significantly different (P<0.05), were the most consistent was Van der Water (QTcV). QTcV values were strongly correlated (r=98) and 95% confidence interval 185.7 to 195.2ms.Considering its simplicity and reliability, the QTcV was deemed the most appropriate to be used for the correction of QT interval in conscious guinea pigs.The results of this study also suggest that the values found can be used as reference for the species.

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Section: Introductionmentioning

confidence: 99%

Computerized electrocardiography in healthy conscious guinea pigs (Cavia porcellus)

et al. 2016

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“…Measurements were made by using the vasovagal tonus index ( vvti ), a time‐domain indicator of heart rate variability. The vvti is the natural logarithm of the variance in the R‐R wave interval measured over 20 consecutive heart cycles on an ecg and it has been used previously to investigate heart rate variability in dogs (Häggström and others 1996, Tarraga and others 2000). It is a time‐domain method of analysis and, being acquired over a short period, provides information about high‐frequency variations in heart rate, which are predominantly a result of vagal influences.…”

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confidence: 99%

Differences between breeds of dog in a measure of heart rate variability

Doxey

Boswood

2004

Veterinary Record

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The vasovagal tonus index (VVTI), a time-domain indicator of heart rate variability, was measured in 92 dogs of six breeds (German shepherd dogs, labrador retrievers, cocker spaniels, boxers, bulldogs and cavalier King Charles spaniels). There was a significant difference in VVTI between the six breeds (P = 0.003). Brachycephalic dogs had a higher VVTI than other types of dog (P < 0.005), and when comparing individual breeds brachycephalic breeds tended to have a higher VVTI than non-brachycephalic breeds, although the difference was not always significant. The VVTI was negatively correlated with heart rate (P < 0.01) and dogs suffering from congestive heart failure had a lower VVTI than other dogs, whether compared within or between breeds (P < 0.01).

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“…Moreover, anesthetic agents could have contributed to some of the differences between ECG results of the present study, compared with other species, because, for instance, humans, cats, and dogs are not generally anesthetized for ECG. It has been suggested that general anesthesia influences cardiac rhythm and the durations of the ST-T segment, QT interval, and QT interval corrected for heart rate [68][69][70] ; however, without knowing the direct impact of the various anesthetic protocols on the ECG results for the chimpanzees in the present study, it was impossible to speculate on this issue further.…”

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confidence: 63%

Evaluation of relationships between results of electrocardiography and echocardiography in 341 chimpanzees (Pan troglodytes)

Drane

Atencia

Cooper

et al. 2020

ajvr

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OBJECTIVETo examine potential relationships between ECG characteristics and echocardiographic measures of cardiac structure in chimpanzees (Pan troglodytes). ANIMALS341 chimpanzees (175 males and 166 females) from 5 sanctuaries and 2 zoological collections. PROCEDURESChimpanzees were anesthetized for routine health examinations between May 2011 and July 2017 as part of the International Primate Heart Project and, during the same anesthetic events, underwent 12-lead ECG and transthoracic echocardiographic assessments. Relationships between results for ECG and those for echocardiographic measures of atrial areas, left ventricular internal diameter in diastole (LVIDd), and mean left ventricular wall thicknesses (MLVWT) were assessed with correlational analysis, then multiple linear regression analyses were used to create hierarchical models to predict cardiac structure from ECG findings. RESULTSFindings indicated correlations (r = -0.231 to 0.310) between results for ECG variables and echocardiographic measures. The duration and amplitude of P waves in lead II had the strongest correlations with atrial areas. The Sokolow-Lyon criteria, QRS-complex duration, and R-wave amplitude in leads V 6 and II had the strongest correlations with MLVWT, whereas the Sokolow-Lyon criteria, QRS-complex duration, and S-wave amplitude in leads V 2 and V 1 had the strongest correlations with LVIDd. However, the ECG predictive models that were generated only accounted for 17%, 7%, 11%, and 8% of the variance in the right atrial end-systolic area, left atrial end-systolic area, MLVWT, and LVIDd, respectively.

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Electrocardiographic evaluation of two anesthetic combinations in dogs

Cited by 9 publications

References 4 publications

Computerized electrocardiography in healthy conscious guinea pigs (Cavia porcellus)

Computerized electrocardiography in healthy conscious guinea pigs (Cavia porcellus)

Differences between breeds of dog in a measure of heart rate variability

Evaluation of relationships between results of electrocardiography and echocardiography in 341 chimpanzees (Pan troglodytes)

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