Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Guest, Francesca L.; Martins-de-Souza, Daniel; Rahmoune, Hassan; Bahn, Sabine; Guest, Paul C.

doi:10.1590/s0101-60832012005000002

Cited by 11 publications

(10 citation statements)

References 104 publications

(117 reference statements)

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“…A growing body of studies has shown the role of the gut–brain axis dysregulation in the pathophysiology of SZ. Subclinical inflammation, aberrant monoamine metabolism, and abnormal hypothalamic–pituitary–adrenal axis activation have been widely reported in patients with SZ [2,3,4,5] and are associated with microbiota alterations [6,7,8,9]. For instance, Schwartz et al [10] found elevated abundance of Lactobacillaceae, Halothiobacillaceae, Brucellaceae, and Micrococcineae and lowered counts of Veillonellaceae in a cohort of SZ patients; in addition, greater microbial abnormalities, lower remission rates, and poorer responses to therapy, as well as decreased microbiome α-diversity index and altered gut microbial composition, were observed in SZ patients [11].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Gut Microbiota and Their Metabolic Potential in Patients with Schizophrenia Treated with Olanzapine: Results from a Six-Week Observational Prospective Cohort Study

Pełka-Wysiecka

Kaczmarczyk

Bąba-Kubiś

et al. 2019

JCM

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Accumulating evidence indicates the potential effect of microbiota on the pathogenesis and course of schizophrenia. However, the effects of olanzapine, second-generation antipsychotics, on gut microbiota have not been investigated in humans. This study aimed to analyze fecal microbiota in schizophrenia patients treated with olanzapine during six weeks of their hospital stay. After a seven-day washout from all psychotropic medications, microbiota compositions were evaluated at baseline and after six weeks of hospitalization using 16S rRNA sequencing. The study was conducted in 20 inpatients, who followed the same hospital routine and received 5–20 mg daily doses of olanzapine. Olanzapine treatment was associated with clinical improvements in all patients and significant increases in body mass index in females, but not changes in gut microbiota compositions and predicted function. The severity of symptoms at the beginning of treatment varied in accordance with the predicted metabolic activity of the bacteria. The present findings indicate that the microbiota of schizophrenia patients is highly individual and has different taxonomical (Type 1, with a predominance of Prevotella, and Type 2 with a higher abundance of Bacteroides, Blautia and Clostridium) and functional clusters, and it does not change following six weeks of olanzapine therapy; in addition, the microbiota is not associated with either the weight gain observed in women or the effectiveness of olanzapine therapy.

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Section: Introductionmentioning

confidence: 99%

Analysis of Gut Microbiota and Their Metabolic Potential in Patients with Schizophrenia Treated with Olanzapine: Results from a Six-Week Observational Prospective Cohort Study

Pełka-Wysiecka

Kaczmarczyk

Bąba-Kubiś

et al. 2019

JCM

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“…Onde a primeira se fixa com a produção de catecolaminas, adrenalina e noradrenalina, esses são exemplos de hormônios monoaminas, estas têm o poder de preparação dos tecidos como o miocárdio, para receber uma intensa a vidade e resis r ao estresse (FONSECA; GONÇALVES; ARAÚJO, 2015). Isto pode afetar diretamente na fisiologia, fazendo com que a frequência cardíaca aumente, vasoconstrição, inibição da insulina e aumento da glicose sanguínea, por exemplo (GUEST et al, 2013).…”

Section: Do Estresse àS Alterações Fisiológicasunclassified

Parâmetros Bioquímicos, Hematológicos E Imunológicos Indicardores De Estresse Em Estudantes Universitários

Lima

Costa

Ferraz³

2021

Rev. Cient. Fac. Med Campos

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O estresse é uma condição muito comum na sociedade, principalmente em estudantes do ensino superior onde se assola muitas dificuldades durante o curso, e ainda, ocorrendo constantemente pode acarretar várias comorbidades, não somente em estudantes, mas em vários indivíduos que continuamente sofrem por situações de estresse em seus cotidianos. Assim, dividiu-se o estresse em duas etapas: a Síndrome de Adaptação Geral, que pode ser explicada como um conjunto de respostas imprecisas de defesa e de Adaptação Orgânica ao Causador, onde é dividida em três partes, que são as fases do estresse, Fase de Alarme ou Alerta, Resistência e Exaustão. Este trabalho tem o quesito principal de investigar a incidência e a influência do grau de estresse nas possíveis alterações bioquímicas, hematológicas e imunológicas em alunos universitários por meio de revisão bibliográfica, buscando então por meios de artigos científicos disponibilizados em diversas bases de dados. A observação dos estudos selecionados foi realizada de forma descritiva, facilitando analisar, computar, descrever e classificar os dados, com a intenção de reunir o conhecimento produzido sobre o tema e estimular um panorama holístico sobre como as situações de estresse são capazes de possibilitarem alterações bioquímicas e hematológicas, tornando mais propícia a diminuição da qualidade de vida de um indivíduo

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“…Literature data show a consistent difference between females and males (3:1 respectively) 5 . In the stress, there is a release of CRH in the hypothalamus, which determines an increase in the secretion of ACTH [6][7][8] . This study aimed to determine whether endocrine variables (cortisol and ACTH) could be related to gender differences in MPA.…”

Section: Dear Editormentioning

confidence: 99%

Music performance anxiety (MPA): endocrine variables and their impact on female

Lima¹,

Silva²,

Rocha³

2016

Arch. Clin. Psychiatry (São Paulo)

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Lima MA et al./ Arch Clin Psychiatry. 2016;43(2):34 Dear Editor, Anxiety is a manifestation with high prevalence in the population. The musical performance requires a high level of skills, making it susceptible to anxiety state 1 . Studies show an alarming incidence of about 50% of music performance anxiety (MPA) among professional musicians [1][2][3][4] . Literature data show a consistent difference between females and males (3:1 respectively) 5 . In the stress, there is a release of CRH in the hypothalamus, which determines an increase in the secretion of ACTH 6-8 . This study aimed to determine whether endocrine variables (cortisol and ACTH) could be related to gender differences in MPA.The following inclusion and exclusion criteria were used: (Inclusion) -adult UFSJ (Sao Joao Del Rei Federal University) music students; (exclusion) -patients with a diagnosis or treatment of psychiatric diseases or uncompensated organic diseases. All the subjects completed and signed the Consent Term and Informed (TCLE), approved by the Ethics Committee of UFSJ. It was applied to version validated for the Portuguese language K-MPAI 9 , which aims to establish scores for the MPA. The higher the score, the more suggestive MPA. Scores of the 4 th quartile of this population were considered high (≥ 136). For the 28 subjects (14 + 14 larger smaller) polar distribution, were made the blood samples to measure cortisol and ACTH. The samples were collected between 08 a.m. and 09 a.m., and the patients were instructed not to smoke, eat, or drink alcohol within 12 hours before the collection. The reference values adopted for cortisol were 05-25 ug/dL and the plasma ACTH 06-76 pg/mL. Statistical analysis sought to establish relations between anxiety levels, gender and cortisol and ACTH. Parametric tests were applied.The study population consisted of 140 subjects who met the inclusion criteria. There were 89 men (average K-MPAI = 106.70; s = 31.88) and 51 women (mean K-MPAI 109.03; s = 35.52). The average age of the study population was 24.8 years. There was significant difference in scores of K-MPAI neither between the female and male groups nor in the lowest score group (14 students). However, in the highest score group (9 men and 5 women) the following pattern was detected: men presented a score in the K-MPAI significantly lower than women (♀ = 161 e ♂ = 145,5) (p ≤ 0.01). In relation to the hormonal dosages, it was demonstrated that, although the concentrations of both cortisol and ACTH were within the normal range (according to reference values), it was found that the ACTH concentrations in the highest K-MPAI score group were significantly higher in women (♀ = 20,3 e ♂ =17,66) (p ≤ 0.05). On the other hand, serum concentrations of cortisol in the male group were significantly higher (♀ = 13,80 e ♂ = 14,68) (p ≤ 0.05) (Figure 1).The results indicate that the ACTH possibly has a role related to the MPA. The discrepancy that occurred in relation to cortisol (Men > Women) could be explained as a function of the cortisol inhibit the HPA...

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Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Cited by 11 publications

References 104 publications

Analysis of Gut Microbiota and Their Metabolic Potential in Patients with Schizophrenia Treated with Olanzapine: Results from a Six-Week Observational Prospective Cohort Study

Analysis of Gut Microbiota and Their Metabolic Potential in Patients with Schizophrenia Treated with Olanzapine: Results from a Six-Week Observational Prospective Cohort Study

Parâmetros Bioquímicos, Hematológicos E Imunológicos Indicardores De Estresse Em Estudantes Universitários

Music performance anxiety (MPA): endocrine variables and their impact on female

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