2010
DOI: 10.1590/s0101-60832010000200007
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Abstract: Sistema colinérgico: revisitando receptores, regulação e a relação com a doença de Alzheimer, esquizofrenia, epilepsia e tabagismo Resumo Objetivo: Revisar a estrutura e o funcionamento do sistema colinérgico central ressaltando seu papel na fisiologia e na fisiopatologia das doenças de Alzheimer e Parkinson, esquizofrenia, epilepsia e tabagismo. Método: Foi realizada uma pesquisa bibliográfica no MedLine, LILACS, PubMed e ISI, e na Biblioteca da Fundação Oswaldo Cruz, RJ, selecionando-se o período de 1914 a 2… Show more

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Cited by 41 publications
(13 citation statements)
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“…29,48 However, if GBB esters interact with muscarinic receptors in other systems, it may cause undesirable effects on sports performance, including bronchoconstriction and increased secretions. If they interact with CNS muscarinic receptors, where the effects are excitation and memory gain, 75 these could benefit sports practice.…”
Section: Discussionmentioning
confidence: 99%
“…29,48 However, if GBB esters interact with muscarinic receptors in other systems, it may cause undesirable effects on sports performance, including bronchoconstriction and increased secretions. If they interact with CNS muscarinic receptors, where the effects are excitation and memory gain, 75 these could benefit sports practice.…”
Section: Discussionmentioning
confidence: 99%
“…There has been a search for natural compounds that could act as acetylcholinesterase (AChE) inhibitors mainly because it is believed delirium (Contestabile, 2011), memory loss in ageing (Gallagher & Colombo, 1995), and Parkinson's disease (Ventura et al, 2010). In the case of Alzheimer's disease (AD), the Cholinergic Hypothesis is the most accepted theory (Järvinen, Vuorela, Hatakka, & Fallarero, 2011;Motta et al, 2016;Vandeput et al, 2015), stating that the loss of cholinergic function contributes to the decrease in cognitive activity associated with AD (Terry & Buccafusco, 2003;Viegas Junior, Bolzani, Furlan, Fraga, & Barreiro, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Hemolytic, ichthyotoxic, and molluscicidal activities of saponins are related to this action on membranes (Castejon 2014). In some situations, receptors present on the cell membrane can induce nitric oxide production, such as is the case of M2 receptors in the heart tissue (Ventura et al 2010). Thus, a change in the integrity of the cell membrane caused by saponins present in A. sisalana crude extract could interfere with the production of NO in Ae.…”
Section: Discussionmentioning
confidence: 99%