Abstract-Fungal microorganisms are widely studied in the bioconversion of substrates. Among them, Pleurotus sajor-caju is well recognized for its known ability to colonize and degrade wastes through solid state bioprocess (SSB). Fruit residues are inexpensive substrates that present characteristics favorable for microorganisms' colonization. The aim of this work was to investigate the mycelial growth of P. sajor-caju on pequi and guavira fruit wastes through SSB, in order to valorize these residues by their biotransformation. Cultivations were carried out with the substrates at pH 5 and with 60% moisture in an incubator at 30 °C for 25 days. Microbiological analyzes for fungi and bacteria beyond proximate composition of the substrates were evaluated every 5 days. It was observed that P. sajor-caju reached maximum growth at the 15 th day in guavira waste and at the 25 th day in pequi waste. The protein enrichments obtained were 30.31% and 37.20% for guavira and pequi wastes, respectively. It was concluded that guavira favored microbial growth and protein concentration, presenting a final product very rich in protein with potential application for animal nutrition.Index Terms-Brazilian savannah, fungi, residues, kinetic.