Efeito hipoglicêmico de rações à base de berinjela (Solanum melongena,L.) em ratos

Abstract

SUMMARYHYPOGLYCEMIC EFFECT OF EGGPLANT (Solanum melongena, L.) IN RATS. The objectives of this work were to verify if eggplant diets exhibit a hypoglycemic effect, if these diets contribute to the post-prandial delay of glucose absorption and if the soluble fiber fraction (pectin) correlates with these effects. Male, adult Wistar rats, both normal and diabetic (alloxan induced) were fed diets based on casein, eggplant with and without the peel and eggplant peel for a 42 days. Blood glucose was determined at the onset of the experiment and at 13, 21, 34 and 42 days. Glucose tolerance oral tests were performed at the end of the experiment. Diets based on eggplant with peel flour and eggplant peel flour showed a significant reduction of plasma glucose levels, but this effect was not observed in the peeled eggplant diet. Diabetic animals consuming the diet based on eggplant with peel exhibited a lesser area under the glucose curve than the other control groups receiving the diets based on casein and eggplant-with-peel and the casein control group. In the animals that received the diets based on peeled eggplant and the eggplant peel, this effect was not observed. It is concluded that the compound responsible by the hypoglycemic effect is present in the peel of the eggplant. It is also concluded that soluble pectin in the diets was not in itself sufficient to promote this effect, but that the continuous administration of the soluble fiber contributed to the improvement of the glucose tolerance. Keywords: diabetes; hypoglycemic effect; soluble pectin; eggplant. EFEITO HIPOGLICÊMICO DE RAÇÕES À BASE DE -INTRODUÇÃOA procura na medicina popular de fontes naturais para prevenção e tratamento das doenças da civilização, entre elas a diabetes, vem sendo cada vez mais intensificada. A importância da inclusão de alimentos que proporcionam uma melhora na tolerância à glicose, em dietas de indivíduos diabéticos, tem sido enfatizada. Atualmente, o extrato e o suco de berinjela, têm sido utilizados para diminuir as taxas de colesterol e de LDLcolesterol [10]. No entanto estudos com a berinjela cozida, como é consumida em preparações alimentícias, não são descritos na literatura.Dietas com alto teor de fibra alimentar têm apresentado resultados positivos em relação a tolerância à glicose, redução de hiperglicemia pós-prandial e taxa secretória de insulina, em indivíduos diabéticos. A fração da fibra solúvel é apontada como responsável por estes efeitos fisiológicos benéficos e vários mecanismos têm sido propostos para explicar sua ação: Alteração na velocidade de difusão da glicose, devido à formação de gel no lúmem intestinal [6,15,17,21]. Alteração na estrutura da mucosa intestinal, com rarefação das criptas e vilosidades da mucosa intestinal e aumento da produção de mucina, que atua como uma barreira à absorção de glicose [3,4,8,19]. A produção de ácidos graxos de cadeia curta, como o acetato e o propionato, em decorrência da fermentação da fibra solúvel pelas bactérias do cólon, também exercem efeitos na diminuição das taxas d...

Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic rat

“…These results indicated that the soluble pectin in the diet contributed to the reduction in the glucose rate of these animals (DERIVI et al, 2002).…”

Assessment of Bioactive Compounds, Physicochemical Composition, and In Vitro Antioxidant Activity of Eggplant Flour

“…4 Studies have shown that phenolic compounds of eggplant have the potential to reduce intestinal glucose Original Article absorption and provide cellular antioxidant protection, preventing oxidation and diabetes complications, 5 especially those phenolic compounds present in eggplant peel. 6 In addition, the eggplant peel is rich in anthocyanins and has therapeutic potential for the treatment of hyperlipidemia and prevention of atherogenic cardiovascular diseases by inhibiting lipid peroxidation. 7 Gonçalves et al 8 conducted a literature review comprising 25 articles on the species S. melongena and concluded that this species has a mitigation effect on dyslipidemia, particularly hypercholesterolemia, when used in the form of juice made from the fruit with peel.…”

Growth, yield, and postharvest quality in eggplant produced under different foliar fertilizer (Spirulina platensis) treatments

“…In recent years, consumption of eggplant (Solanum melongena L.) has increased considerably due to its medicinal properties (GONÇALVES et al, 2006;RAIGÓN et al, 2008), mainly because of its cholesterol-reducing properties (JORGE et al, 1998) and hypoglycemic effect (DERIVI et al, 2002). Eggplants are rich in vitamins B1 and B2 and minerals including calcium, phosphorus, iron, and potassium (RIBEIRO et al, 1998).…”