Trans fatty acid intake is associated with insulin sensitivity but independently of inflammation

Angelieri, C.T.; Barros, Camila Risso de; Siqueira-Catania, Antonela; Ferreira, Sandra Roberta Gouvêa

doi:10.1590/s0100-879x2012007500071

Cited by 19 publications

(11 citation statements)

References 22 publications

(35 reference statements)

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“…This particular pattern was nominally associated with increased levels of insulin, a finding consistent with current literature, suggesting meat consumption to be associated with hyperinsulinaemia and type 2 diabetes [38,55]. The total fat, mainly consisting of the saturated fat of the meat and the trans fatty acids of the fried potatoes, is believed to contribute to the increased prevalence of insulin resistance and type 2 diabetes [56][57][58].…”

Section: Discussionsupporting

confidence: 83%

A Dietary Pattern with High Sugar Content Is Associated with Cardiometabolic Risk Factors in the Pomak Population

et al. 2019

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The present study describes the geographically isolated Pomak population and its particular dietary patterns in relationship to cardiovascular risk factors. We collected a population-based cohort in a cross-sectional study, with detailed anthropometric, biochemical, clinical, and lifestyle parameter information. Dietary patterns were derived through principal component analysis based on a validated food-frequency questionnaire, administered to 1702 adult inhabitants of the Pomak villages on the Rhodope mountain range in Greece. A total of 69.9% of the participants were female with a population mean age of 44.9 years; 67% of the population were overweight or obese with a significantly different prevalence for obesity between men and women (17.5% vs. 37.5%, respectively, p < 0.001).Smoking was more prevalent in men (45.8% vs. 2.2%, p < 0.001), as 97.3% of women had never smoked. Four dietary patterns emerged as characteristic of the population, and were termed "high in sugars", "quick choices", "balanced", and "homemade". Higher adherence to the "high in sugars" dietary pattern was associated with increased glucose levels (p < 0.001) and increased risk of hypertension (OR (95% CI) 2. 61 (1.55, 4.39), p < 0.001) and nominally associated with high blood glucose levels (OR (95% CI) 1.85 (1.11, 3.08), p = 0.018), compared to lower adherence. Overall, we characterize the dietary patterns of the Pomak population and describe associations with cardiovascular risk factors.

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Section: Discussionsupporting

confidence: 83%

A Dietary Pattern with High Sugar Content Is Associated with Cardiometabolic Risk Factors in the Pomak Population

et al. 2019

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“…The authors speculated that TFA interferes with insulin signaling predominantly via intracellular kinases, which alter insulin receptor substrates [34]. …”

Section: Insulin Sensitivity and Resistancementioning

confidence: 99%

“…Chronically excessive triacylglycerol accumulation in tissues such as the liver, muscle, and pancreatic beta cells leads to a protective response involving adaptation of the adipocytes, and this response includes activation of several inflammatory pathways that promote adipose tissue insulin resistance [34]. …”

Section: Hepatic Injurymentioning

confidence: 99%

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

Estadella

Nascimento

Oyama

et al. 2013

Mediators of Inflammation

145

100

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The ingestion of excessive amounts of saturated fatty acids (SFAs) and transfatty acids (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity. The focus of this paper was to elucidate the influence of dietary SFA and TFA intake on the promotion of lipotoxicity to the liver and cardiovascular, endothelial, and gut microbiota systems, as well as on insulin resistance and endoplasmic reticulum stress. The saturated and transfatty acids favor a proinflammatory state leading to insulin resistance. These fatty acids can be involved in several inflammatory pathways, contributing to disease progression in chronic inflammation, autoimmunity, allergy, cancer, atherosclerosis, hypertension, and heart hypertrophy as well as other metabolic and degenerative diseases. As a consequence, lipotoxicity may occur in several target organs by direct effects, represented by inflammation pathways, and through indirect effects, including an important alteration in the gut microbiota associated with endotoxemia. Interactions between these pathways may perpetuate a feedback process that exacerbates an inflammatory state. The importance of lifestyle modification, including an improved diet, is recommended as a strategy for treatment of these diseases.

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“…It has been estimated that 72,000 cardiovascular disease-related deaths per year could be averted by a 1% reduction in the intake of industrially produced TFAs [8]. Furthermore, high TFA intake is generally considered as a risk factor for weight gain [9], although the evidence for the relationship between TFA intake and diabetes is inconsistent [10][11][12][13][14]. A recent meta-analysis confirmed that TFA intake is associated with all-cause mortality and coronary heart disease mortality [15].…”

Section: Introductionmentioning

confidence: 99%

Trans fatty acid intake among Chinese population: a longitudinal study from 1991 to 2011

Jiang¹,

Shen²,

Zhao³

et al. 2020

Lipids Health Dis

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Objective: This study was aimed to roughly describe individual Trans Fatty Acids (TFAs) intake and the percentage of energy intake(E%), and identify major food sources in the Chinese population, taking gender, age, and regional distribution into the consideration, as well as examining temporal changes over the course of 20 years. Method: This multi-center study, covering nine provinces among populations aged ≥ 3 in China, was conducted to collect food consumption information from 1991 to 2011. A classical assessment method was used to estimate the level of dietary TFA intake.Results: Over the 20-year period, the intake of TFAs in Chinese populations had increased, but remained at a relatively lower level (from 0.25 g/d(0.11% for E%) to 0.53 g/d(0.24% for E%)) compared with that of other countries and the World Health Organization (WHO) recommended level. Collectively, males and participants aged 19-60 generally consumed more TFA-containing foods. People in eastern regions consumed more TFAs and had a higher E% than those in western area. Industrial sources of TFAs, especially vegetable oil, ranked as the principal food sources of TFAs in the Chinese population. Natural sources of TFAs have gradually increased in proportion among children and adolescents.Conclusions: TFA intake and the E% are commonly under the recommended level in the general population in China. Presently, restriction of vegetable oil could be a crucial method to reduce TFA intake. It would be critical to facilitate and promote public health that food recommendations might be based on the dietary preferences for population separated by different ages and regions.

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Trans fatty acid intake is associated with insulin sensitivity but independently of inflammation

Cited by 19 publications

References 22 publications

A Dietary Pattern with High Sugar Content Is Associated with Cardiometabolic Risk Factors in the Pomak Population

A Dietary Pattern with High Sugar Content Is Associated with Cardiometabolic Risk Factors in the Pomak Population

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

Trans fatty acid intake among Chinese population: a longitudinal study from 1991 to 2011

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