TRP channels, omega-3 fatty acids, and oxidative stress in neurodegeneration: from the cell membrane to intracellular cross-links

Leonelli, Mauro; Graciano, Maria Fernanda Rodrigues; Britto, Luiz Roberto Giorgetti de

doi:10.1590/s0100-879x2011007500124

Cited by 10 publications

(8 citation statements)

References 80 publications

(107 reference statements)

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“…Some of these TRP channels have been reported to play important roles in regulating energy metabolism in BAT in rodents and humans (23)(24)(25). For instance, TRPV1-predominantly expressed on perivascular sensory neurons-is widely considered an integrator of stimuli, including those of capsaicin, heat, and acid conditions among others (26,27). More recently, we have also reported that eicosapentaenoic acid-and docosahexaenoic acid-enriched fish oil intake activates gastrointestinal TRPV1 and induces BAT thermogenesis in rodents (28).…”

mentioning

confidence: 93%

10‐oxo‐12( Z )‐octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1

et al. 2017

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Gut microbiota can regulate the host energy metabolism; however, the underlying mechanisms that could involve gut microbiota-derived compounds remain to be understood. Therefore, in this study, we investigated the effects of KetoA [10-oxo-12()-octadecenoic acid]-a linoleic acid metabolite produced by gut lactic acid bacteria-on whole-body energy metabolism and found that dietary intake of KetoA could enhance energy expenditure in mice, thereby protecting mice from diet-induced obesity. By using Ca imaging and whole-cell patch-clamp methods, KetoA was noted to potently activate transient receptor potential vanilloid 1 (TRPV1) and enhance noradrenalin turnover in adipose tissues. In addition, KetoA up-regulated genes that are related to brown adipocyte functions, including uncoupling protein 1 (UCP1) in white adipose tissue (WAT), which was later diminished in the presence of a β-adrenoreceptor blocker. By using obese and diabetic model KK-Ay mice, we further show that KetoA intake ameliorated obesity-associated metabolic disorders. In the absence of any observed KetoA-induced antiobesity effect or UCP1 up-regulation in TRPV1-deficient mice, we prove that the antiobesity effect of KetoA was caused by TRPV1 activation-mediated browning in WAT. KetoA produced in the gut could therefore be involved in the regulation of host energy metabolism.-Kim, M., Furuzono, T., Yamakuni, K., Li, Y., Kim, Y.-I., Takahashi, H., Ohue-Kitano, R., Jheng, H.-F., Takahashi, N., Kano, Y., Yu, R., Kishino, S., Ogawa, J., Uchida, K., Yamazaki, J., Tominaga, M., Kawada, T., Goto, T. 10-oxo-12()-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1.

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confidence: 93%

10‐oxo‐12( Z )‐octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1

et al. 2017

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“…Some fatty acids are important constituents of cell membranes [1], while others are precursors of potent bioactive lipids [2]. Imbalances in fatty acids can lead to a wide variety of diseases, including inflammation [3], neurodegeneration [4], tumorigenesis [5,6], metabolic disorders [7,8] and cardiovascular disease [9].…”

Section: Introductionmentioning

confidence: 99%

“…Acid-catalyzed methods can be used for methylating total FAs (esterified and non-esterified fatty acids), while base-catalyzed methods are not capable of derivatizing free fatty acids [10]. Base-catalyzed methods consist of mild reactions suitable for methylating fatty acids bound within acylglycerides [11] in A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 4 reactions requiring anhydrous conditions. Acid-catalyzed methods can be used either in direct transesterification or in a two-step methylation including initial hydrolysis or saponification of the lipids to free fatty acids.…”

Section: Introductionmentioning

confidence: 99%

An efficient and robust fatty acid profiling method for plasma metabolomic studies by gas chromatography–mass spectrometry

Chiu

Tsai

Tseng

et al. 2015

Clinica Chimica Acta

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“…Recently, capsinoids, a group of capsaicin analogues, were shown to activate gastrointestinal TRPV1 and induce BAT thermogenesis in humans and rodents 27 . Furthermore, TRPV1 agonists found in foods, such as fish oil, could regulate TRPV1 in the gastrointestinal tract 28 29 .…”

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confidence: 99%

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system

Kim

Goto

et al. 2015

Sci Rep

152

138

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Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis, and may provide novel strategies for the treatment of human obesity. BAT-mediated thermogenesis is regulated by mitochondrial uncoupling protein 1 (UCP1) in classical brown and ectopic beige adipocytes, and is controlled by sympathetic nervous system (SNS). Previous work indicated that fish oil intake reduces fat accumulation and induces UCP1 expression in BAT; however, the detailed mechanism of this effect remains unclear. In this study, we investigated the effect of fish oil on energy expenditure and the SNS. Fish oil intake increased oxygen consumption and rectal temperature, with concomitant upregulation of UCP1 and the β3 adrenergic receptor (β3AR), two markers of beige adipocytes, in the interscapular BAT and inguinal white adipose tissue (WAT). Additionally, fish oil intake increased the elimination of urinary catecholamines and the noradrenaline (NA) turnover rate in interscapular BAT and inguinal WAT. Furthermore, the effects of fish oil on SNS-mediated energy expenditure were abolished in transient receptor potential vanilloid 1 (TRPV1) knockout mice. In conclusion, fish oil intake can induce UCP1 expression in classical brown and beige adipocytes via the SNS, thereby attenuating fat accumulation and ameliorating lipid metabolism.

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TRP channels, omega-3 fatty acids, and oxidative stress in neurodegeneration: from the cell membrane to intracellular cross-links

Cited by 10 publications

References 80 publications

10‐oxo‐12( Z )‐octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1

10‐oxo‐12( Z )‐octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1

An efficient and robust fatty acid profiling method for plasma metabolomic studies by gas chromatography–mass spectrometry

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system

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