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Cited by 16 publications
(11 citation statements)
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References 38 publications
(33 reference statements)
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“…Indeed, results from our laboratory indicate that the main endothelial mediator responsible for regulating the coronary vascular tone (represented by the baseline CPP) is the NO in both Wistar and SHR rats (Santos et al, 2004, 2010, 2016). Therefore, ovariectomy leads to damages on the endothelial function, as previously showed by our study group (Borgo et al, 2011; Caliman et al, 2013; Claudio et al, 2013; Oliveira et al, 2014; Lamas et al, 2015); impairing thus, the preventive/therapeutic effects from the PHE on the baseline CPP values in the OVX-PHE group. Another suggestion is that the beneficial effects from the treatment are probably dependent on circulating estrogen levels in the blood, since we observed that animals with normal estrogen levels (Sham) showed the benefits generated by the treatment.…”
Section: Discussionsupporting
confidence: 71%
“…Indeed, results from our laboratory indicate that the main endothelial mediator responsible for regulating the coronary vascular tone (represented by the baseline CPP) is the NO in both Wistar and SHR rats (Santos et al, 2004, 2010, 2016). Therefore, ovariectomy leads to damages on the endothelial function, as previously showed by our study group (Borgo et al, 2011; Caliman et al, 2013; Claudio et al, 2013; Oliveira et al, 2014; Lamas et al, 2015); impairing thus, the preventive/therapeutic effects from the PHE on the baseline CPP values in the OVX-PHE group. Another suggestion is that the beneficial effects from the treatment are probably dependent on circulating estrogen levels in the blood, since we observed that animals with normal estrogen levels (Sham) showed the benefits generated by the treatment.…”
Section: Discussionsupporting
confidence: 71%
“…Furthermore, menopause can increase the incidence of CVD because of a reduction in the 17β-estradiol concentrations (1). This reduction can also worsen the degree of hypertension in SHR (7,8,16), as also demon strated in our study. Hormone therapy is a treatment commonly used to relieve symptoms associated with menopause and also to prevent CVD.…”
Section: Discussionsupporting
confidence: 87%
“…However, the decline in estrogens production in the postmenopausal period can raise the risk for the development of hypertension and, consequently, CHD (4,5). Animal studies showed that ovariectomy increases blood pressure (BP) of normotensive rats (6) and even worsens the hypertensive state of spontaneously hypertensive rats (SHR) (7,8). …”
Section: Introductionmentioning
confidence: 99%
“…Borgo et al discovered attenuated acetylcholine-induced coronary vasoconstriction and enhanced adenosine-induced coronary vasodilatation after tamoxifen administration, which suggested a beneficial effect of tamoxifen therapy on coronary vascular reactivity. 23 El Gebeily et al demonstrated that tamoxifen could possibly reduce cardiac arrhythmia by interfering with the potassium channel current, which also implied the protective potential of tamoxifen. 24 Zhao et al revealed that by improving mitochondrial function in an animal model, tamoxifen protected against cardiac-injuring tumor necrosis factor α, 25 which was a novel potential therapeutic target for atrial fibrosis.…”
Section: Resultsmentioning
confidence: 99%