A high-carbohydrate diet enhances the adverse effect of the S2 allele of APOC3 SstI polymorphism on the TG/HDL-C ratio only in young Chinese females

Song, Yongyan; Gong, Rui; Zhang, Zhen; Li, Yuan Hao; Xiao, Li; Zhou, Xue; Fang, Ding Zhi

doi:10.1590/s0100-879x2011007500065

Cited by 2 publications

(1 citation statement)

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“…However, the association was also strongly correlated with BMI. On the contrary, Song et al ( 47 ) found in a group of Chinese healthy young college students that an intervention with a high carbohydrate (70% total calorie intake) LFD (15% total calorie intake) had favorable effects on TC, LDL-c, and HDL-c ratios, regardless of gender or Apolipoprotein C3 ( APOC3 ) SstI polymorphism ( p = 0.001).…”

Section: Resultsmentioning

confidence: 99%

Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review

et al. 2022

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BackgroundObesity and dyslipidemias are risk factors for developing cardiovascular diseases, the leading causes of morbidity and mortality worldwide. The pathogenesis of these diseases involves environmental factors, such as nutrition, but other aspects like genetic polymorphisms confer susceptibility to developing obesity and dyslipidemias. In this sense, nutrigenetics is being used to study the influence of genetic variations on the circulating lipid responses promoted by certain nutrients or foods to provide specific dietary strategies considering the genetic factors in personalized nutrition interventions.ObjectiveTo identify throughout a systematic review the potential nutrigenetic recommendations that demonstrate a strong interaction between gene-diet and circulating lipid variations.MethodsThis systematic review used the PRISMA-Protocol for manuscript research and preparation using PubMed and ScienceDirect databases. Human studies published in English from January 2010 to December 2020 were included. The main results were outcomes related to gene-diet interactions and plasmatic lipids variation.ResultsAbout 1,110 articles were identified, but only 38 were considered to fulfill the inclusion criteria established based on the reported data. The acquired information was organized based on gene-diet interaction with nutrients and components of the diet and dietary recommendation generated by each interaction: gene-diet interaction with dietary fats, carbohydrates or dietary fiber, gene-diet interaction with nutraceutical or dietary supplementation, and gene-diet interaction with proteins.ConclusionFindings included in this systematic review indicated that a certain percentage of dietary macronutrients, the consumption of specific amounts of polyunsaturated or monounsaturated fatty acids, as well as the ingestion of nutraceuticals or dietary supplements could be considered as potential strategies for the development of a wide range of nutrigenetic interventions since they have a direct impact on the blood levels of lipids. In this way, specific recommendations were identified as potential tools in developing precision diets and highlighted the importance of personalized nutrition. These recommendations may serve as a possible strategy to implement as dietary tools for the preventive treatment and control alterations in lipid metabolism.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021248816, identifier [CRD42021248816].

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Section: Resultsmentioning

confidence: 99%

Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review

et al. 2022

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Nutrigenetics of cholesterol metabolism: observational and dietary intervention studies in the postgenomic era

2015

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Cholesterol metabolism is a well-defined responder to dietary intakes and a classic biomarker of cardiovascular health. For this reason, circulating cholesterol levels have become key in shaping nutritional recommendations by health authorities worldwide for better management of cardiovascular disease, a leading cause of mortality and one of the most costly health problems globally. Data from observational and dietary intervention studies, however, highlight a marked between-individual variability in the response of cholesterol metabolism to similar dietary protocols, a phenomenon linked to genetic heterogeneity. This review summarizes the postgenomic evidence of polymorphisms within cholesterol-associated genes relative to fasting circulating cholesterol levels under diverse nutritional conditions. A number of cholesterol-related gene-diet interactions are confirmed, which may have clinical importance, supporting a deeper look into the rapidly emerging field of nutrigenetics for meaningful conclusions that may eventually lead to genetically targeted dietary recommendations in the era of personalized nutrition.

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A high-carbohydrate diet enhances the adverse effect of the S2 allele of APOC3 SstI polymorphism on the TG/HDL-C ratio only in young Chinese females

Cited by 2 publications

References 38 publications

Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review

Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review

Nutrigenetics of cholesterol metabolism: observational and dietary intervention studies in the postgenomic era

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