Antinociceptive effect on mice of the hydroalcoholic fraction and (-) epicatechin obtained from Combretum leprosum Mart &amp; Eich

Lopes, Luís Carlos; Marques, Rosemarie Brandim; Pereira, S.S.; Ayres, Mariane Cruz Costa; Chaves, Mariana Helena; Cavalheiro, Alberto José; Júnior, Gerardo Magela Vieira; Almeida, Fernanda Campos Sousa de

doi:10.1590/s0100-879x2010007500121

Cited by 20 publications

(2 citation statements)

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“…Capsaicin activates C and Aδ fibers in afferent neurons by stimulating TRPV1 receptors, which leads to the influx of Ca 2+ and Na + , triggering pain (Abdel-Salam and Mózsik, 2023). We demonstrated that EENL diminished the paw licking/biting time in this model, which is in line with the study by Lopes et al (Lopes et al, 2010) who reported that epicatechin reduced the licking/biting time in the capsaicin test.…”

Section: Discussionsupporting

confidence: 93%

“…First, we observed that the pretreatment with EENL reduced the number of abdominal writhes in mice after intraperitoneal administration of acetic acid. The antinociceptive effect of EENL in this model is in line with the demonstration that pretreatment with either ellagic acid (Rogerio et al, 2006) or epicatechin (Lopes et al, 2010) reduced the number of abdominal writhes induced by acetic acid in mice.…”

Section: Discussionsupporting

confidence: 86%

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Antinociceptive effect of Nephelium lappaceum L. fruit peel and the participation of nitric oxide, opioid receptors, and ATP-sensitive potassium channels

Oliveira,

Biano,

Palmeira

et al. 2023

Front. Pharmacol.

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Introduction:Nephelium lappaceum L. (Sapindaceae) is a plant known as rambutan. It is used for various purposes in traditional medicine.Objective: We aimed to evaluate the antinociceptive effects of the ethanol extract of the fruit peel of N. lappaceum (EENL), the mechanisms involved in these effects, and the acute toxicity in zebrafish.Methods: We performed chromatography coupled to mass spectrometry, acute toxicity assay in zebrafish, and evaluation in mice submitted to models of nociception and locomotor activity.Results: We identified (epi)-catechin, procyanidin B, and ellagic acid and its derivatives in EENL. We did not find any toxicity in zebrafish embryos incubated with EENL. The locomotor activity of mice submitted to oral pretreatment with EENL was not changed, but it reduced the abdominal constrictions induced by acetic acid, the licking/biting time in both the first and second phase of formalin testing and capsaicin testing, and carrageenan-induced paw mechanical allodynia. Oral pretreatment with EENL increased latency time in the hot plate test. This antinociceptive effect was significantly reversed by naloxone, L-arginine, and glibenclamide respectively showing the participation of opioid receptors, nitric oxide, and KATP channels as mediators of EENL-induced antinociception.Conclusion: EENL causes antinociception with the participation of opioid receptors, nitric oxide, and KATP channels, and is not toxic to zebrafish.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 86%