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citations
Cited by 18 publications
(10 citation statements)
references
References 29 publications
(26 reference statements)
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“…Although previous evidence has shown a correlation between NCTD treatment and Wnt impairment [51], we show here for the first time that these two compounds can impair endogenous Wnt-b-catenin signaling in MB cell lines by promoting loss of nuclear b-catenin. Furthermore, the ability to impair the direct Wnt target survivin can be regarded as a new interesting aspect for treatment of unfavorable MB tumors, given that high survivin expression is associated with unfavorable patient outcome in MB, as is also seen in other forms of cancer [52].…”
Section: Discussioncontrasting
confidence: 53%
“…Although previous evidence has shown a correlation between NCTD treatment and Wnt impairment [51], we show here for the first time that these two compounds can impair endogenous Wnt-b-catenin signaling in MB cell lines by promoting loss of nuclear b-catenin. Furthermore, the ability to impair the direct Wnt target survivin can be regarded as a new interesting aspect for treatment of unfavorable MB tumors, given that high survivin expression is associated with unfavorable patient outcome in MB, as is also seen in other forms of cancer [52].…”
Section: Discussioncontrasting
confidence: 53%
“…The EC 50 values for ICG001 and FH535 equaled 4.2±0.55µM and 14.91±1.70µM, respectively (Fig.8B). As our findings regarding the inhibitory potential of ICG001 and FH535 are consistent with literature, the H1703-7TFP system seems to be a specific and confident assay [8,9,44]. In order to investigate whether the compounds selected during the screening assay presented anticancer activity, we examined the effects of ICG001 inhibitor and compound 47 on the proliferation of HCT116 colorectal cancer cell line.…”
Section: Pilot Screening Of the Wnt/β-catenin Pathway Inhibitorssupporting
confidence: 81%
“…To determine whether transcriptional control of EMT regulators by LEF1 depends only on β‐catenin, we used inhibitors of Wnt signaling (IWR, IWR‐endo), siRNA targeted to β‐catenin, and a deletion mutant of the LEF1 β‐catenin‐binding domain to examine effects of β‐catenin activity on the reporter assay in the presence and absence of LEF. Reporter construct TOP flash, a plasmid containing WREs, was used initially to determine whether Huh7 cells responded to Wnt‐3a. Luc activity was induced by Wnt‐3a, and such induction was inhibited by IWR (Supporting Fig.…”
Section: Resultsmentioning
confidence: 99%