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Cited by 24 publications
(13 citation statements)
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“…Furthermore, agmatine inhibits nitric oxide synthase (NOS) isoforms by suppressing catalytic activity ( 24 ). Previous studies have suggested that agmatine may protect retinal ganglion cells from oxidative stress ( 25 , 26 ), promote glial cell survival in spinal cord injury ( 27 ) and attenuate LPS-induced microglial damage ( 28 ). However, the majority of studies have focused on the protective effects of agmatine via NMDAR inhibition in the neurons, or via NOS inhibition in the glial cells of the central nervous system (CNS).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, agmatine inhibits nitric oxide synthase (NOS) isoforms by suppressing catalytic activity ( 24 ). Previous studies have suggested that agmatine may protect retinal ganglion cells from oxidative stress ( 25 , 26 ), promote glial cell survival in spinal cord injury ( 27 ) and attenuate LPS-induced microglial damage ( 28 ). However, the majority of studies have focused on the protective effects of agmatine via NMDAR inhibition in the neurons, or via NOS inhibition in the glial cells of the central nervous system (CNS).…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, although agmatine is currently a compound of interest in the field of neuroscience, its potential activities related to otology have not yet been explored. In previous studies, agmatine was shown exert to protective effects against cell damage and cellular apoptosis in human neuroblastoma cells, hippocampal neuronal cells, and retinal neuronal cells [5-9, 21, 22]. Although this study investigated the protective effects of agmatine on auditory cells, previous studies have mainly shown its protective effects on neuronal cells.…”
Section: Discussionmentioning
confidence: 93%
“…The marked reduction in antioxidant status in NIC group reflected that nicotine exhibited oxidative stress. The efficient amelioration of oxidant/antioxidant imbalance induced by AG was proved by Lee et al [40] who postulated such ameliorating effect due to suppressing NF-кB activation in hyperglycemic rabbit mesengial cells and Iizuka et al [41] proved such action via alpha-2 adrenergic signaling in retinal ganglion cells.…”
Section: Discussionmentioning
confidence: 98%