“…At least in SCA3, patients may respond well to treatments aimed at improving the ways in which they deal with their disability, such as occupational therapy [11]. That our data support the view that depressive symptoms in SCA3 are not primarily related to the underlying pathological process could be a matter of debate.…”
“…At least in SCA3, patients may respond well to treatments aimed at improving the ways in which they deal with their disability, such as occupational therapy [11]. That our data support the view that depressive symptoms in SCA3 are not primarily related to the underlying pathological process could be a matter of debate.…”
“…On the contrary, a small controlled trial of riluzole in a heterogeneous cohort of ataxia patients suggested a short-term symptomatic effect of this compound that has to be validated in larger trials [48 ]. In addition, there are ongoing activities to demonstrate the beneficial effects of nonpharmacological interventions such as physiotherapy or occupational therapy [42,43,49].…”
Section: Clinical Assessment Methods and Therapeutic Trialsmentioning
Recent molecular advances underline the diversity of degenerative ataxias. With the progress in the development of clinical assessment methods for ataxia, the methodological requirements to run large interventional trials are now met.
“…Improvements in depressive symptoms were obtained in the varenicline RCT [92], and in open-labeled trials with Fluoxetine [71] and occupational therapy [108]. We have experience with the use of different AD in SCA3/MJD patients generally with good response.…”
Section: Psychiatric Symptomsmentioning
confidence: 98%
“…Case reports on dopaminergic drugs response [ Depressive symptoms Improvements in depressive symptoms were obtained in open-labeled trials with Fluoxetine [71] and with occupational therapy [108] Efficacy proved Expert Opinion…”
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