Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
14
0

Year Published

2010
2010
2019
2019

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 16 publications
(16 citation statements)
references
References 18 publications
2
14
0
Order By: Relevance
“…In our recent work, we found the methanolic leaf extract of L. micranthus to elicit a dose-dependent inhibition of blood pressure elevation in adrenaline induced hypertensive rat (Iwalokun et al, unpublished) to corroborate previous reports [15, 17]. Recently, Ameer et al [21] reported the n-butanol fraction from the methanolic leaf extract of L. ferrugineus was found to elicit dose-dependent inhibition of KCl and phenylephrine induced aortic ring contraction coupled with blood pressure lowering effect in rats. Therefore, we hypothesize that mechanisms exist to mediate the hypotensive action of L. micranthus , which remain largely unknown.…”
Section: Introductionsupporting
confidence: 85%
See 4 more Smart Citations
“…In our recent work, we found the methanolic leaf extract of L. micranthus to elicit a dose-dependent inhibition of blood pressure elevation in adrenaline induced hypertensive rat (Iwalokun et al, unpublished) to corroborate previous reports [15, 17]. Recently, Ameer et al [21] reported the n-butanol fraction from the methanolic leaf extract of L. ferrugineus was found to elicit dose-dependent inhibition of KCl and phenylephrine induced aortic ring contraction coupled with blood pressure lowering effect in rats. Therefore, we hypothesize that mechanisms exist to mediate the hypotensive action of L. micranthus , which remain largely unknown.…”
Section: Introductionsupporting
confidence: 85%
“…The EC 50 and R max values due to the n-butanol fraction against epinephrine-induced aorta contraction were found to be 0.65 mg/mL and 75.2%, respectively. Inhibition of rat aorta smooth muscle contraction due to KCl and phenylephrine another α -adrenergic receptor agent has also been reported for L. ferrugineus fractions and the n-butanol fraction was also found to be the most potent fraction but with a median effective concentration (EC 50 ) of 38.4 ug/mL and maximum relaxation ( R max ) effect of 80.5% against phenylephrine induced contraction and EC 50 of 726 ug/mL and R max of 20.7% against KCl induced contraction [21]. In this study, for the water and chloroform fractions of L.micranthus , we obtained EC 50 values of 1.18 mg/mL/>1.5 mg/mL and >1.5 mg/mL/>1.5 mg/mL and R max values of 56.5%/10.4% and 35.9%/10.4% against PE/KCl induced contraction of the rat aorta smooth muscle, whereas EC 50 values of 230 ug/mL/8.3 ug/mL and 217 ug/mL/933 ug/mL and R max values of 53.7%/14.3% and 22.4%/6.6% were reported for these fractions from L. ferrugineus .…”
Section: Discussionmentioning
confidence: 97%
See 3 more Smart Citations