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Cited by 4 publications
(3 citation statements)
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References 27 publications
(23 reference statements)
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“…Synthetic DNA enzymes that specifically degrade Egr-1 mRNA prevent the induction of Egr-1 protein expression in human and rat aortic vascular smooth muscle cells ( 20 22 ). In previous studies, Egr-1 DNA enzyme reduced the mRNA and protein expression of Egr-1 in aortic smooth muscle cells and inhibited cell proliferation and migration ( 23 ). This property has been successfully applied to suppress gene expression.…”
Section: Discussionmentioning
confidence: 85%
“…Synthetic DNA enzymes that specifically degrade Egr-1 mRNA prevent the induction of Egr-1 protein expression in human and rat aortic vascular smooth muscle cells ( 20 22 ). In previous studies, Egr-1 DNA enzyme reduced the mRNA and protein expression of Egr-1 in aortic smooth muscle cells and inhibited cell proliferation and migration ( 23 ). This property has been successfully applied to suppress gene expression.…”
Section: Discussionmentioning
confidence: 85%
“…In previous studies, synthetic DNA enzymes that specifically degraded Egr-1 mRNA were shown to block induction of Egr-1 protein expression in human and rat aortic VSMCs [14,15] and inhibit cell proliferation and wound repair in culture. Our previous study [10] demonstrated the specificity and efficacy of synthetic ED5 for inhibiting Egr-1 expression, which inhibited VSMC proliferation, most probably by downregulating the expression of Cyclin D1 and TGF-β1. However, it remained unclear whether ED5 could inhibit Egr-1 proliferation-related downstream target genes and the expression of inflammatory cell adhesion molecules.…”
Section: Discussionmentioning
confidence: 99%
“…In a previous study, we synthesized a specific DNA enzyme targeting rat Egr-1 mRNA (DNA enzyme/10-23, ED5) and introduced it into primary cultures of rat VSMCs. We found that ED5 specifically inhibited the expression of Egr-1 and inhibited VSMCs proliferation, probably by downregulating the expression of Cyclin D1 and TGF-β1 [10]. Preliminary experiments indicated that the Egr-1-specific deoxyribozyme (ED5) inhibits cell proliferation and intimal hyperplasia.…”
Section: Introductionmentioning
confidence: 99%