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Cited by 12 publications
(13 citation statements)
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“…In both instances, the early phase is associated with enhanced expression of Angpt2 and Vegfa expression locally around the wound; Vegfa is upregulated in keratinocytes, whereas Angpt2 is increased in endothelial cells (13,26). Accordingly, we induced a controlled tissue injury using an ear punch (27). In Angpt1 del/^(E13.…”
Section: Discussionmentioning
confidence: 99%
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“…In both instances, the early phase is associated with enhanced expression of Angpt2 and Vegfa expression locally around the wound; Vegfa is upregulated in keratinocytes, whereas Angpt2 is increased in endothelial cells (13,26). Accordingly, we induced a controlled tissue injury using an ear punch (27). In Angpt1 del/^(E13.…”
Section: Discussionmentioning
confidence: 99%
“…Controls (n = 10) and Angpt1 del/^(E13.5) (n = 9) mice (induced with DOX from E13.5 to E16.5) were used for the experiments. A hole was punched in the center of the cartilaginous part of the left ear, using a 2.05-mm diameter metal ear punch (Harvard Apparatus) as described previously (27). Photographs of wounds were taken in the presence of a scaled ruler after 60 days.…”
mentioning
confidence: 99%
“…A resposta a lesões em organismos complexos como mamíferos apresenta uma capacidade de reparo limitada (COSTA et al, 2009). Em mamíferos adultos, o processo de reparo ocorre pela substituição de células maduras, mas não de órgãos, e há formação de cicatriz, diferente do que é observado em invertebrados ou anfíbios (GOUREVITCH et al, 2003).…”
Section: Cicatrizaçãounclassified
“…Um caso semelhante de regeneração foi observado por acaso em ratos MRL, com reconstituição de lesão na orelha em 30 dias (GARCIA, 2007;COSTA et al, 2009).…”
Section: Cicatrizaçãounclassified
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