The association of ACE gene D/I polymorphism with cardiovascular risk factors in a population from Rio de Janeiro

Cardoso, Renan; Nogueira, Ana; Salis, Lucia Helena Alvares; Ürményi, Turán P.; Silva, R.; Pereira, Basílio de Bragança; Rondinelli, Edson; Silva, N.A. de Souza e

doi:10.1590/s0100-879x2008000600013

Cited by 9 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The D/D genotype is not only a risk factor for hypertension and diabetes but it is also associated with their complications. Recent study reported that D allele may increase the risk of cardiovascular disease by facilitating the development of left ventricular hypertension, microalbuminuria and low HDL cholesterol, especially among men (7). Dell'omo and colleagues, 2006 found that the D allele in hypertensive patients poses a higher risk for microalbuminuria and treatment with ACE inhibitors produces a greater reduction in microalbuminuria in hypertensive patients homozygous for the I allele.…”

Section: Discussionmentioning

confidence: 99%

Association of angiotensin converting enzyme gene (I/D) polymorphism with hypertension and type 2 diabetes

Zarouk¹,

Hussein²,

Esmaiel³

et al. 2012

BLL

View full text Add to dashboard Cite

Objectives: This study was conducted to determine the association of insertion/deletion (I/D) polymorphism of the ACE gene in hypertensive and T2DM subjects in Egyptian population. Background: The deletion (D) allele of the angiotensin-converting enzyme (ACE) gene has been studied in relation to hypertension and type 2 diabetes mellitus (T2DM) with contradictory results which might be due to ethnic and geographical variations. Methods: A total of 85 subjects participated in this study; hypertension (Group 1); type 2 diabetes mellitus (Group 2) and controls (Group 3). Written informed consent was obtained. for each subject: age, sex, diabetes duration and the drugs used, blood pressure (systolic and diastolic), and lipid profi le. Genotyping was performed by polymerase chain reaction (PCR). Results: The frequency of DD genotype was signifi cantly higher in hypertensive (60 %) and diabetic patients (68 %) compared to controls (33.3 %) (p=0.04, p=0.01 respectively). The DD genotype (vs DI and II genotype) in the hypertensive and diabetic groups is associated with increased risk of hypertension and/or diabetes. OR=3.00; 95%, Cl = 0.993-9.067; OR=4.250; 95%, Cl = 1.234-14.63 respectively). The D allele was more frequent in hypertensive (77.5 %) and diabetic patients (82 %) compared to controls (52.4 %) (p=0.004 and 0.002 respectively). The D allele (vs the I allele) is associated with increased risk of hypertension and diabetes OR=3.13, 95%Cl=1.405-6.978; OR= 4.14, 95% CI= 1.615-10.622 respectively). Conclusion: The DD genotype and the D allele are associated with hypertension and type 2 diabetes in Egyptian patients (Tab. 5, Fig. 1, Ref. 32). Full Text in free PDF www.bmj.sk.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of angiotensin converting enzyme gene (I/D) polymorphism with hypertension and type 2 diabetes

Zarouk¹,

Hussein²,

Esmaiel³

et al. 2012

BLL

View full text Add to dashboard Cite

show abstract

“…This finding is in disagreement with the results of Legro et al (32) who observed that PCOS patients more frequently exhibited low HDL cholesterol levels and hypertriglyceridemia. Cardoso et al (33), who investigated the association between the ACE gene D/I polymorphism and lipid profile, demonstrated that, in the general population, women with the DD genotype had the highest mean values of triglyceride levels, while women with the II genotype had the highest mean values of HDL cholesterol (33). The subjects in the PCOS group in the present study had higher concentrations of HDL cholesterol and lower TG levels, and the majority of them had the DD genotype.…”

Section: Discussionmentioning

confidence: 99%

Association between the angiotensin converting enzyme gene insertion/deletion polymorphism and metabolic disturbances in women with polycystic ovary syndrome

Ożegowska

Bogacz

Bartkowiak‐Wieczorek

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. A number of PCOS complications may be associated with the elevated level of angiotensin II and low bradykinin concentrations. The aim of the present study was to investigate the frequencies of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms in women with PCOS and to determine the association between ACE genetic variants and the risk of metabolic and cardiovascular complications in such women. A total of 138 PCOS patients and 110 healthy volunteers were enrolled. Cardiovascular risk was estimated according to the criteria of the American Heart Association and Androgen Excess and PCOS Society. The median average age was 28.5 (26.0‑31.0) and 27.0 (24.0‑30.0) years in the control and PCOS groups, respectively (P=0.004). Anthropometric parameters, including body mass index and waist circumference were significantly higher in the PCOS patients. In the PCOS group, 97 (57.4%) of the subjects were metabolically unhealthy, whereas, in the control group 51 (46.4%) subjects were (P=0.07). The II, ID, and DD genotypes frequencies were 29.1, 44.5, and 26.4% in the controls and 5.0, 37.7, and 57.3% in the PCOS patients. The cardioprotective I allele was observed significantly less frequently in the women with PCOS compared with the controls [odds ratio (OR), 3.27; P=0.0001]. The DD genotype, which is known to increase cardiovascular risk, was more frequently observed in PCOS patients (OR, 3.87; P=0.0003), whereas the cardioprotective II genotype occurred in this group less frequently (OR, 0.4; P=0.06). The results of the present study demonstrated a statistically significant association between the ACE I/D polymorphism and the presence and intensity of metabolic disturbances in women with PCOS.

show abstract

“…These findings have also paved the way for the identification of a novel metabolic pathway for HDL-C and its relationship to CVD, though the results of many studies have been often inconsistent [ 14 ]. The gene polymorphisms related to the renin-angiotensin system have not been included in the candidate genetic variations for HDL-C [ 14 ], but a difference in HDL-C levels between individuals with different genotypes of angiotensin-converting enzyme was also seen in a population-based study [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Angiotensin II Type 2 Receptor Gene A/C3123 Polymorphism and High-Density Lipoprotein Cholesterol with Hypertension in Asymptomatic Women

2012

View full text Add to dashboard Cite

Objective: The present study investigated the association between the angiotensin II type 2 receptor (AT2R) gene adenine/cytosine (A/C)-3123 polymorphism and cardiometabolic variables in subjects with and without hypertension. Methods: Cardiometabolic variables, in addition to genotyping by an allele-specific DNA assay, were measured in 161 asymptomatic community-dwelling Japanese women (age range 30–83 years). They were divided into hypertensive (n = 82, age 50–81 years) and nonhypertensive (n = 79, age 30–83 years) subjects. Results: The A-allele carriers (n = 53) showed significantly lower high-density lipoprotein cholesterol (HDL-C) levels than the non-A-allele carriers (n = 26) among nonhypertensive subjects (1.45 ± 0.38 vs. 1.66 ± 0.33 mmol/l, p = 0.02). Even when multiple-adjusted analyses were performed, the HDL-C levels continued to differ significantly and independently of other variables, including the body mass index and insulin resistance index, between A-allele and non-A-allele carriers. However, this association was not observed among hypertensive subjects. Conclusion: The present study demonstrated that A-allele carriers had significantly lower HDL-C levels than did non-A-allele carries among nonhypertensive women, while this association was not observed among hypertensive women. This indicates that the A/C3124 polymorphism may be a marker associated with HDL metabolism by hypertension. This was a small study, so further research is warranted to confirm the observed association.

show abstract

The association of ACE gene D/I polymorphism with cardiovascular risk factors in a population from Rio de Janeiro

Cited by 9 publications

References 23 publications

Association of angiotensin converting enzyme gene (I/D) polymorphism with hypertension and type 2 diabetes

Association of angiotensin converting enzyme gene (I/D) polymorphism with hypertension and type 2 diabetes

Association between the angiotensin converting enzyme gene insertion/deletion polymorphism and metabolic disturbances in women with polycystic ovary syndrome

Association between Angiotensin II Type 2 Receptor Gene A/C3123 Polymorphism and High-Density Lipoprotein Cholesterol with Hypertension in Asymptomatic Women

Contact Info

Product

Resources

About