2007
DOI: 10.1590/s0100-879x2007001100005
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Abstract: Ectopic gastric mucosa (EGM) is considered to be a congenital condition. Rare cases of adenocarcinoma have been described. There are no data justifying regular biopsies or follow-up. Cyclooxygenase-2 (COX-2) is a protein involved in gastrointestinal tumor development by inhibiting apoptosis and regulating angiogenesis. The aim of this prospective study was to evaluate COX-2 expression in EGM and compare it with normal tissue and Barrett's esophagus. We evaluated 1327 patients. Biopsies were taken from the inle… Show more

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Cited by 7 publications
(5 citation statements)
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“…Results indicated that healthy nonglandular equine gastric mucosa expressed COX-1 and that most stomach specimens did not express COX-2. This observation is in agreement with results of previous studies 22,26,27 performed on human squamous esophagus mucosa and on nonglandular gastric mucosa in pigs. Results are also in line with common knowledge that COX-1 is the constitutive isoform and COX-2 is the inducible isoform of COX in most tissues.…”
Section: Discussionsupporting
confidence: 93%
“…Results indicated that healthy nonglandular equine gastric mucosa expressed COX-1 and that most stomach specimens did not express COX-2. This observation is in agreement with results of previous studies 22,26,27 performed on human squamous esophagus mucosa and on nonglandular gastric mucosa in pigs. Results are also in line with common knowledge that COX-1 is the constitutive isoform and COX-2 is the inducible isoform of COX in most tissues.…”
Section: Discussionsupporting
confidence: 93%
“…However, few studies investigated the relationship between H. pylori infection and the COX‐2 expression in esophagus. Some studies reported that gastric H. pylori infection do not interfere esophageal COX‐2 expression [16,17]. In an in vitro study, Abdel‐Latif [18] reported that H. pylori extract induced COX‐2 expression in cultured esophageal adenocarcinoma cells.…”
Section: Discussionmentioning
confidence: 99%
“…Selective COX‐2 inhibitors, nimesulide and sulindac, have been found to be effective in preventing BE and esophageal adenocarcinoma in rats by suppressing COX‐2 expression [14,15]. Although studies in vivo find no correlation between gastric H. pylori infection and COX‐2 expression in esophagus [16,17], coculture with H. pylori induces COX‐2 expression in esophageal adenocarcinoma cell lines SKGT‐4 and OE33, indicating that COX‐2 inhibitor may play a role in preventing esophageal adenocarcinoma [18].…”
mentioning
confidence: 99%
“…Yamagata et al and Sung et al demonstrated a high expression of COX-2 in the epithelium of the crypts of intestinal metaplasia and Sun demonstrated ascending tendency of COX-2 expression from chronic superficial gastritis to gastric cancer [14][15][16]. Overexpression of COX-2 has been demonstrated in others gastrointestinal cancer and premalignant lesions as colorectal adenomas and Barrett's esophagus [17,18] and these results suggest the involvement of COX-2 earlier in gastrointestinal carcinogenesis.…”
Section: Discussionmentioning
confidence: 92%