2007
DOI: 10.1590/s0100-879x2007000600017
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Abstract: The ability of the clinically used cephalosporins: cephalothin, cefotaxime and cefotiam to induce lipid peroxidation (LPO) and renal damage was compared to that of nephrotoxic cephaloridine under in vivo conditions. Glutathione was measured in rat liver or in renal cortex as non-protein sulfhydryls. LPO was measured in plasma, renal cortex and liver by the generation of malondialdehyde or as the increase in renal cortical concentration of conjugated dienes. Impairment of renal function was measured as the decr… Show more

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Cited by 4 publications
(2 citation statements)
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“…Oxidized lipid intake or lipid peroxidation can contribute to the development of tumors and atherosclerosis. Clinical studies suggest lipid peroxidation can be partially counteracted by vitamin E intake [57,58,59,60]. …”
Section: Vitamin Ementioning
confidence: 99%
“…Oxidized lipid intake or lipid peroxidation can contribute to the development of tumors and atherosclerosis. Clinical studies suggest lipid peroxidation can be partially counteracted by vitamin E intake [57,58,59,60]. …”
Section: Vitamin Ementioning
confidence: 99%
“…ß-Lactam-induced tubular necrosis has been attributed mainly to impaired import and oxidation of monocarboxylate substrates by mitochondria, as well as to cellular antioxidant depletion and lipid peroxidation [26,27]. Most cephalosporins are excreted to a significant fraction or even predominantly via the kidneys in humans [28,29].…”
Section: Direct Proximal Tubular Toxicity Of Oat Drug Substratesmentioning
confidence: 99%