Antinociceptive properties in mice of a lectin isolated from the marine alga Amansia multifida Lamouroux

Neves, S. A.; Freitas, Ana Lúcia Ponte; Sousa, Benildo; Rocha, Marina Becker Sales; Correia, M. V. O.; Sampaio, Daniela; Viana, G. S. B.

doi:10.1590/s0100-879x2007000100016

Cited by 44 publications

(21 citation statements)

References 11 publications

(10 reference statements)

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“…Also, there is a study demonstrating the inhibitory effect of lectin isolated from Amansia multifida in both phases with predominance in phase 2, causing 61 and 48% inhibition of licking time at the doses of 5 and 10 mg kg -1 , p.o., and 60, 88, and 69% inhibition after i.p. administration of 1, 2, and 5 mg kg -1 , respectively of the formalin test (Neves et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Protective effects of ethanolic extract from the red algae Amansia multifida on experimental inflammation, nociception and seizure experimental models

Aragão

Nonato

Ponte

et al. 2016

Acta Sci. Biol. Sci.

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ABSTRACT. This study aimed to investigate the EEAm effect in mice models of nociception, inflammation and in behavioral tests evaluating the central nervous system. EEAm had inhibitory effects in the following tests: acetic acid-induced writhing (78%); formalin (62% -inflammatory phase); open field (46%). EEAm increased the nociceptive latency (56%) in tail flick test and increased the death-latency by 36% in the pentylenetetrazole-induced seizure model. Moreover, EEAm inhibited paw edema (82%) and peritonitis (45%) induced by carrageenan. In conclusion, EEAm presents antinociceptive, antiinflammatory and anticonvulsant effects involving peripheral and central-acting mechanisms in mice.Keywords: acute inflammatory process, antinociception, epilepsy, red seaweed.Efeito protetor do extrato etanólico da alga marinha vermelha Amansia multifida em modelos experimentais de inflamação, nocicepção e convulsão RESUMO. Neste estudo objetivou-se investigar o efeito do EEAm em modelos de nocicepção e inflamação, e em testes comportamentais que avaliam o sistema nervoso central em camundongos. EEAm exibiu efeitos inibitórios nos testes comportamentais de contorções abdominais induzidas por ácido acético (78%); formalina (62% -fase inflamatória) e campo aberto (46%). EEAm aumentou a latência de nocicepção no teste de retirada da cauda (56%) e a latência de morte 36% no modelo de convulsões induzidas por pentilenetetrazol. Além disso, EEAm inibiu o edema de pata (82%) e a peritonite (45%) induzidos por carragenana. Como conclusão, EEAm apresenta efeitos antinociceptivo, anti-inflamatório e anticonvulsivante em camundongos por mecanismos periféricos e centrais.Palavras-chave: Processo inflamatório agudo, antinocicepção, epilepsia, alga vermelha.

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Section: Resultsmentioning

confidence: 99%

Protective effects of ethanolic extract from the red algae Amansia multifida on experimental inflammation, nociception and seizure experimental models

Aragão

Nonato

Ponte

et al. 2016

Acta Sci. Biol. Sci.

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“…The formalin test, which causes local tissue injury to the paw, is a model for tonic or neurogenic pain and localized inflammatory pain (Neves et al, 2007). Neurogenic pain is caused by direct activation of nociceptive nerve terminals, while inflammatory pain is mediated by a combination of peripheral input and spinal cord sensitization (Hunskaar and Hole, 1987).…”

Section: Discussionmentioning

confidence: 99%

Quercetin: Further investigation of its antinociceptive properties and mechanisms of action

et al. 2008

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The antinociceptive action of quercetin, a common bioactive flavonoid present in many medicinal plants, was assessed in different models of chemical and thermal nociception in mice. Quercetin (10-60 mg/kg, i.p. or 100-500 mg/kg, p.o.) dose-dependently inhibited nociceptive behavior in the acetic acid-induced pain test. Moreover, quercetin (10-60 mg/kg, i.p.) inhibited both phases of formalin-induced pain, with ID50 values of 374.1 (68.0-402.0) mmol/kg and 103.0 (45.0-201.0) mmol/kg, for the neurogenic and inflammatory phases, respectively. Quercetin (10-60 mg/kg) also inhibited the nociception induced by glutamate and capsaicin by 68.2% and 75.5%, respectively. Its analgesic action was significantly reversed by p-chlorophenylalanine methyl ester, katanserin, methysergide, a GABA(A) antagonist (bicuculline), or a GABA(B) antagonists (baclofen). Its action was also modulated by tachykinins, but was not affected by adrenal-gland hormones. Furthermore, the antinociceptive effects did not result from muscle-relaxant or sedative action. Together, these results indicate that quercetin produces dose-related anti-nociception in several models of chemical pain, through mechanisms that involve interaction with L-arginine-nitric oxide, serotonin, and GABAergic systems. These results confirm and extend other investigations on the analgesic effect of quercetin and its mechanisms of action.

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“…Previous studies have demonstrated the antinociceptive effect of alga lectins, both at central and peripheral levels. These effects were shown with lectins from marine algae Amansia multifida Lamouroux [8], Bryothamnium seaforthii and Bryothamnium triquetrum [9].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 90%

Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides

Vanderlei

Patoilo

Lima

et al. 2010

International Immunopharmacology

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The search for new compounds for controlling pain and inflammation, with minimal side effects has focused on marine algae. The aim of this work was to investigate the effect of the purified lectin from the green marine alga Caulerpa cupressoides (CcL) in classical models of nociception and inflammation. Male Swiss mice received i.v. CcL 30 min prior to receiving 0.8% acetic acid (10 ml/kg; i.p); 1% formalin (20 microl; s.c.) or were subjected to thermal stimuli. We observed that CcL (3, 9 or 27 mg/kg) significantly reduced the number of writhes induced by acetic acid by 37.2%; 53.5% and 86.0%, respectively. CcL (27 mg/kg) also reduced the second phase of the formalin test. However, CcL (27 mg/kg) did not present significant antinociceptive effects in the hot plate test, when compared to morphine, suggesting that its antinociceptive action occurs predominantly through a peripheral mechanism. The antinociceptive effects were abolished when CcL was pre-incubated with mucin (20mg/kg; i.v.). When CcL (9 mg/kg) was administered i.v. in Wistar rats 30 min before carrageenan administration, neutrophil counts were reduced by 65.9%. CcL also inhibited paw edema in all time intervals, especially at the third hour. Finally, CcL (9 mg/kg) administered i.v. in mice did not cause hepatic or renal alterations and did not affect body mass or macroscopy of the organs examined. In conclusion, CcL appears to have important antinociceptive and anti-inflammatory activities and could represent an important agent for future studies.

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Antinociceptive properties in mice of a lectin isolated from the marine alga Amansia multifida Lamouroux

Cited by 44 publications

References 11 publications

<b>Protective effects of ethanolic extract from the red algae <i>Amansia multifida</i> on experimental inflammation, nociception and seizure experimental models

<b>Protective effects of ethanolic extract from the red algae <i>Amansia multifida</i> on experimental inflammation, nociception and seizure experimental models

Quercetin: Further investigation of its antinociceptive properties and mechanisms of action

Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides

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