2007
DOI: 10.1590/s0100-879x2006005000086
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Abstract: The objective of the present study was to determine whether sleep deprivation (SD) would promote changes in lymphocyte numbers in a type 1 diabetes model (non-obese diabetic, NOD, mouse strain) and to determine whether SD would affect female and male NOD compared to Swiss mice. The number of lymphocytes in peripheral blood after 24 and 96 h of SD (by multiple platform method) or equivalent period of time in home-cage controls was examined prior to the onset of diabetes. SD for 96 h significantly reduced lympho… Show more

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Cited by 37 publications
(26 citation statements)
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“…Regarding the general reduction of immune cell populations in saline-treated mice, these data are in accordance with previous findings showing decreased circulating lymphocyte populations after PSD in humans [25,26] and rodents [17,18,27] . The current study expanded our previous findings [18] by demonstrating that this reduction occurs not only in circulating lymphocytes but also in spleen and in other cell subtypes, such as macrophages, NK cells and dendritic cells.…”
Section: Discussionsupporting
confidence: 92%
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“…Regarding the general reduction of immune cell populations in saline-treated mice, these data are in accordance with previous findings showing decreased circulating lymphocyte populations after PSD in humans [25,26] and rodents [17,18,27] . The current study expanded our previous findings [18] by demonstrating that this reduction occurs not only in circulating lymphocytes but also in spleen and in other cell subtypes, such as macrophages, NK cells and dendritic cells.…”
Section: Discussionsupporting
confidence: 92%
“…Leukocyte counts in blood were determined on the same day by an automatic blood cell counter (Advia 120 Hematology System), which employs a combination of myeloperoxidase staining, cell size and nuclear lobulation to obtain differential count of circulating neutrophils, lymphocytes and monocytes. Moreover, a number of recent studies have been published using this system for blood cell count in both rats [18] and mice [17] .…”
Section: Leukocyte Distribution In Circulation and Immune Organsmentioning
confidence: 99%
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“…Several studies have demonstrated that sleep loss leads to significant alterations in many immune components both in laboratory animals and humans [5,36,37]. In this way, we have verified that sleep deprivation, when applied immediately before EAT inoculation, potentiates its growth.…”
Section: Discussionsupporting
confidence: 77%
“…One of the most common stressors of modern society is sleep deprivation (SD). SD can exert negative effects in many systems, such as decreases in cognitive performance, changes in hormonal levels, mood and behavior, and deleterious effects on the immune system [7,8,9,10,11,12,13]. In particular, paradoxical SD (PSD) can affect the homeostasis of the skin barrier in humans and animals.…”
Section: Introductionmentioning
confidence: 99%