Immunoglobulin production is impaired in protein-deprived mice and can be restored by dietary protein supplementation

Amaral, J.F.; Foschetti, D.A.; Assis, F.A.; Menezes, J.S.; Vaz, N.M.; Faria, A.M.C.

doi:10.1590/s0100-879x2006005000045

Cited by 6 publications

(3 citation statements)

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“…Indeed, we have shown previously that the immature state of adult aa-fed C57BL/6 mice is not permanent and immunological maturity can be restored by feeding a diet containing 10% protein for a period as short as 72 hr. 27 The immature immunological state of aa-fed mice is similar to that reported for germ-free mice. These animals also show poorly developed GALT, and low levels of secretory IgA and serum IgG and IgA.…”

Section: Discussionsupporting

confidence: 72%

Antigenic dietary protein guides maturation of the host immune system promoting resistance to Leishmania major infection in C57BL/6 mice

Amaral¹,

Gomes-Santos²,

Paula-Silva³

et al. 2010

Immunology

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Summary The immature immune system requires constant stimulation by foreign antigens during the early stages of life to develop properly and to create efficient immune responses against later infections. We have previously shown that intake of antigenic dietary protein is critical for inducing maturation of the immune system as well as for the development of T helper type 1 (Th1) immunity. In this study, we show that administration of an amino acid (aa)‐based diet during the development of the immune system subsequently resulted in inefficient control of Leishmania major infection in adult C57BL/6 mice. Compared with mice fed a control protein‐containing diet, adult aa‐fed mice showed a decreased interferon (IFN)‐γ response to parasite antigens and insufficient production of nitric oxide (NO), which is crucial to parasite death. However, no deviation towards Th2‐specific immunity to L. major was observed. Phenotypic analysis of antigen‐presenting cells (APCs) from aa‐fed mice revealed deficient levels of the costimulatory molecules CD40 and CD80, and low levels of interleukin (IL)‐12 produced by peritoneal macrophages, revealing an early stage of maturation of these cells. APCs isolated from aa‐fed mice were unable to stimulate a Th1 response in vitro. Both phenotypic features of T cells from aa‐fed mice and their ability to produce a Th1 response in the presence of mature APCs were unaffected when compared with T cells from control mice. The results presented here support the notion that regulation of Th1 immunity to infection includes environmental factors such as dietary proteins, which provide a natural source of stimulation that contributes to the process of maturation of APCs.

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Section: Discussionsupporting

confidence: 72%

Antigenic dietary protein guides maturation of the host immune system promoting resistance to Leishmania major infection in C57BL/6 mice

Amaral¹,

Gomes-Santos²,

Paula-Silva³

et al. 2010

Immunology

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“…Animal and human studies show decreased serum immunoglobulin levels during a low-protein diet. 3-5…”

Section: Introductionmentioning

confidence: 99%

Impact of Vegetarian Diet on Serum Immunoglobulin Levels in Children

Gorczyca

Prescha

Szeremeta

2013

Clin Pediatr (Phila)

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“…When Aa-fed adult mice are fed a diet containing at least 5% casein for 72 h, they develop normal levels of serum IgG and IgA (Amaral et al, 2006). This indicates that the defect observed in immunological maturation is related to the low antigenic stimulation rather than stimulation at a special period of life.…”

Section: Food Proteins In the Maturation Of Immune Systemmentioning

confidence: 99%

Food Components and the Immune System: From Tonic Agents to Allergens

Faria¹,

Gomes-Santos²,

Gonçalves³

et al. 2013

Front. Immunol.

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The intestinal mucosa is the major site of contact with antigens, and it houses the largest lymphoid tissue in the body. In physiological conditions, microbiota and dietary antigens are the natural sources of stimulation for the gut-associated lymphoid tissues (GALT) and for the immune system as a whole. Germ-free models have provided some insights on the immunological role of gut antigens. However, most of the GALT is not located in the large intestine, where gut microbiota is prominent. It is concentrated in the small intestine where protein absorption takes place. In this review, we will address the involvement of food components in the development and the function of the immune system. Studies in mice have already shown that dietary proteins are critical elements for the developmental shift of the immature neonatal immune profile into a fully developed immune system. The immunological effects of other food components (such as vitamins and lipids) will also be addressed. Most of the cells in the GALT are activated and local pro-inflammatory mediators are abundant. Regulatory elements are known to provide a delicate yet robust balance that maintains gut homeostasis. Usually antigenic contact in the gut induces two major immune responses, oral tolerance and production of secretory IgA. However, under pathological conditions mucosal homeostasis is disturbed resulting in inflammatory reactions such as food hypersensitivity. Food allergy development depends on many factors such as genetic predisposition, biochemical features of allergens, and a growing array of environmental elements. Neuroimmune interactions are also implicated in food allergy and they are examples of the high complexity of the phenomenon. Recent findings on the gut circuits triggered by food components will be reviewed to show that, far beyond their role as nutrients, they are critical players in the operation of the immune system in health and disease.

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Immunoglobulin production is impaired in protein-deprived mice and can be restored by dietary protein supplementation

Cited by 6 publications

References 1 publication

Antigenic dietary protein guides maturation of the host immune system promoting resistance to Leishmania major infection in C57BL/6 mice

Antigenic dietary protein guides maturation of the host immune system promoting resistance to Leishmania major infection in C57BL/6 mice

Impact of Vegetarian Diet on Serum Immunoglobulin Levels in Children

Food Components and the Immune System: From Tonic Agents to Allergens

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