2005
DOI: 10.1590/s0100-879x2005001200008
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Abstract: The objective of the present investigation was to perform a 14-day time-course study of treatment with salbutamol, a ß 2 adrenoceptor agonist, on rat soleus muscle in order to assess fiber type selectivity in the hypertrophic response and fiber type composition. Male Wistar rats were divided into four groups: control (N = 10), treated with salbutamol (N = 30), denervated (N = 30), and treated with salbutamol after denervation (N = 30). Salbutamol was injected intraperitoneally in the rats of the 2nd and 4th gr… Show more

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Cited by 10 publications
(2 citation statements)
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“…Such change is detectable as early as 1 h after a single bout of exercise (57,58). White‐to‐red fiber conversion has been described in response to exercise (59) and other interventions associated with increased intracellular energetic expenditure such as electrical stimulation (60), cross‐reinnervation (61), a diet rich in carnitine, carnosine and taurine (62), beta adrenergic stimulation (63), androgen receptor antagonism (64) and mild heat stress (65). However, the results of this study are limited to describing an up‐regulation of oxidative capacity as measured by cytochrome oxidase activity.…”
Section: Discussionmentioning
confidence: 99%
“…Such change is detectable as early as 1 h after a single bout of exercise (57,58). White‐to‐red fiber conversion has been described in response to exercise (59) and other interventions associated with increased intracellular energetic expenditure such as electrical stimulation (60), cross‐reinnervation (61), a diet rich in carnitine, carnosine and taurine (62), beta adrenergic stimulation (63), androgen receptor antagonism (64) and mild heat stress (65). However, the results of this study are limited to describing an up‐regulation of oxidative capacity as measured by cytochrome oxidase activity.…”
Section: Discussionmentioning
confidence: 99%
“…Both muscle fibers and the extracellular matrix (ECM), respond directly to electrical stimuli, by means of contraction of the actin and myosin filaments and regulation of protein synthesis in the ECM, respectively 4 . Therefore, impairments of muscle innervation affect both muscle fiber, as evidenced by the decrease in the fiber's cross sectional area (CSA) 5,6 , and the ECM, observed by the increase of intramuscular connective tissue (CT) 6,7 . As a result, the denervated muscle shows a deficient function, as demonstrated by the decreases in force production and increases in passive resistance [8][9][10] .…”
Section: Introductionmentioning
confidence: 99%