2005
DOI: 10.1590/s0100-879x2005000600012
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Abstract: Mercury is a xenobiotic metal that is a highly deleterious environmental pollutant. The biotransformation of mercury chloride (HgCl 2 ) into methylmercury chloride (CH 3 HgCl) in aquatic environments is well-known and humans are exposed by consumption of contaminated fish, shellfish and algae. The objective of the present study was to determine the changes induced in vitro by two mercury compounds (HgCl 2 and CH 3 HgCl) in cultured human lymphocytes. Short-term human leukocyte cultures from 10 healthy donors (… Show more

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Cited by 62 publications
(27 citation statements)
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“…Changes in this value suggest influence of exogenous factors and let us preliminarily conclude about the type of action of these factors (Ma et al 2005;Silva-Pereira et al 2005;Sang et al 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Changes in this value suggest influence of exogenous factors and let us preliminarily conclude about the type of action of these factors (Ma et al 2005;Silva-Pereira et al 2005;Sang et al 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Similar to our finding, a doserelated increase in DNA damage was observed in human cultured human peripheral blood lymphocytes . Likewise, significant increases in the frequencies of chromosome aberrations (CAs) and SCEs were observed for HgCl 2 in cultured human lymphocytes (Rao et al 2001;Silva-Pereira et al 2005;Halder et al 2005). HgCl 2 was found to be genotoxic in bacterial mutagenicity assays (Schurz et al 2000).…”
Section: Discussionmentioning
confidence: 98%
“…Elemental, inorganic, and organic forms of mercury exhibit toxicologic characteristics including nephrotoxicity, neurotoxicity, and gastrointestinal toxicity with ulceration and hemorrhage (Zalups and Koropatnick 2000). Besides, the genotoxicity of mercuric compounds have been reported in both in vitro and in vivo model systems (Silva-Pereira et al 2005;Grotto et al 2010;. Recent findings elucidated that mechanism of mercury toxicity included production of reactive oxygen species (ROS) capable of damaging lipids in membrane, proteins or enzymes in tissues, and DNA to induce oxidative stress (Jan et al 2011).…”
Section: Introductionmentioning
confidence: 99%
“…3B), suggesting a non-cytotoxic mode of damage. Indeed, genotoxicity of mercuric compounds has been reported in both in vitro and in vivo model systems [54,55] as well as in bacterial mutagenicity assays [56]. This may been seen from a much higher response of the genotoxic sensitive strain DPD2794.…”
Section: Response Of the Biosensor To Different Pollutantsmentioning
confidence: 99%