2004
DOI: 10.1590/s0100-879x2004000700015
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Abstract: Increased dopamine catabolism may be associated with oxidative stress and neuronal cell death in Parkinson's disease. The present study was carried out to examine the effect of dopamine on the expression of heme oxygenase-1 and -2 (HO-1 and HO-2) in human neuroblastomas (SK-N-SH cell line) and the effects of selegiline and antioxidants on this expression. Cells were kept with close control of pH and were incubated with varying concentrations of dopamine (0.1-100 µM) for 24 h. HO-1 and HO-2 cDNA probes were pre… Show more

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Cited by 8 publications
(8 citation statements)
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“…1998a). DA‐derived pro‐oxidant intermediates, MPTP‐like neurotoxins generated endogenously or stemming from the environment, and microglia‐derived cytokines and NO are plausible inducers of astroglial HMOX1 gene expression in the PD nigra (Rieder et al. 2004; Schipper 2004a).…”
Section: Parkinson Diseasementioning
confidence: 99%
“…1998a). DA‐derived pro‐oxidant intermediates, MPTP‐like neurotoxins generated endogenously or stemming from the environment, and microglia‐derived cytokines and NO are plausible inducers of astroglial HMOX1 gene expression in the PD nigra (Rieder et al. 2004; Schipper 2004a).…”
Section: Parkinson Diseasementioning
confidence: 99%
“…HO‐1 expression in brain tissue and in vitro cultures of brain cells has been shown to be inducible by several drugs, chemicals and dietary‐derived substances (Table 1), which is similar to the response of other cells and tissues (reviewed in Shibahara, 2003 ; Wagener et al ., 2003 ; Ogborne et al ., 2004 ; Ryter et al ., 2006 ). Athough there is an extensive literature dealing with HO‐1 expression by rodent glial, particularly the microglia ( Matsuoka et al ., 1998 ; Calingasan et al ., 1999 ; Mautes et al ., 2000 ; Nakaso et al ., 2000 ; Stahnke et al ., 2007 ), there is surprisingly little data available on HO‐1 expression by human neural cells, being restricted to a few studies on human tumour cell lines ( Takahashi et al ., 1996 ; Businaro et al ., 2002 ; Goldstein et al ., 2003 ; Rieder et al ., 2004 ). As might be expected, exposure of 118 INI human glioma cells ( Yoshida et al ., 1988 ) or differentiated SH‐SY5Y human neuroblastoma cells ( Goldstein et al ., 2003 ) to haemin induced HO‐1 protein expression and, similar to mouse primary astrocytes and rat C6 glioma cells, dopamine exposure induced HO‐1 expression in the SK‐N‐SH human neuroblastoma cell line ( Rieder et al ., 2004 ).…”
Section: Induction Of Ho‐1 In Brain Cellsmentioning
confidence: 99%
“…Athough there is an extensive literature dealing with HO‐1 expression by rodent glial, particularly the microglia ( Matsuoka et al ., 1998 ; Calingasan et al ., 1999 ; Mautes et al ., 2000 ; Nakaso et al ., 2000 ; Stahnke et al ., 2007 ), there is surprisingly little data available on HO‐1 expression by human neural cells, being restricted to a few studies on human tumour cell lines ( Takahashi et al ., 1996 ; Businaro et al ., 2002 ; Goldstein et al ., 2003 ; Rieder et al ., 2004 ). As might be expected, exposure of 118 INI human glioma cells ( Yoshida et al ., 1988 ) or differentiated SH‐SY5Y human neuroblastoma cells ( Goldstein et al ., 2003 ) to haemin induced HO‐1 protein expression and, similar to mouse primary astrocytes and rat C6 glioma cells, dopamine exposure induced HO‐1 expression in the SK‐N‐SH human neuroblastoma cell line ( Rieder et al ., 2004 ). Myelin basic protein, which is released during demyelination, was found to induce HO‐1 mRNA and protein in the T67 astrocytoma cell line ( Businaro et al ., 2002 ), whereas agents that release nitric oxide and cause nitrosative stress increased HO‐1 expression in T98G glioblastoma cells ( Takahashi et al ., 1996 ).…”
Section: Induction Of Ho‐1 In Brain Cellsmentioning
confidence: 99%
“…It has been reported that Hsc70 (Li et al, 1996; Creagh and Cotter, 1999; Koul et al, 2008) and HO‐1 (Rieder et al, 2004) exert neuroprotective effect. Here, we examine whether resistin regulates Hsc70 and HO‐1 expression.…”
Section: Resultsmentioning
confidence: 99%