Effects of caffeine on learning and memory in rats tested in the Morris water maze

Abstract

We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, P£0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats was up to 500 cm shorter, P£0.05). In contrast, pre-training caffeine administration did not alter the performance of the animals either in the training or in the test session. These data provide evidence that caffeine improves memory retention but not memory acquisition, explaining some discrepancies among reports in the literature. Correspondence

Activation of Adenosine A2AReceptor Impairs Memory Acquisition but not Consolidation or Retrieval Phases

“…Recently, the overexpression of A 2A receptors was reported to cause deficits in working memory (Giménez-Llort et al, 2007), suggesting that the activations of these receptors deteriorates memory performance. Several studies have also demonstrated that adenosine receptor agonists disrupt learning and memory in rats and mice (Normile and Barraco, 1991;Normile et al, 1994;Ohno and Watanabe, 1996), and that adenosine receptor antagonists facilitate learning and memory as determined by the passive avoidance task (Nehlig et al, 1992, Suzuki et al, 1993, Kopf et al, 1999Pereira et al, 2002) and another maze task in rodents (Angelucci et al, 1999, Hauber and Bareiss, 2001and Angelucci et al, 2002. In the present study, CV-1808 (an adenosine A 2A receptor agonist) impaired memory acquisition according to the passive avoidance and Morris water maze tasks.…”

The Impact of Caffeine on the Behavioral Effects of Ethanol Related to Abuse and Addiction: A Review of Animal Studies

“…106,107 Other studies have shown that moderate doses of ethanol delivered after learning generally enhance or have little effect on memory examined the next day, 108,109 and caffeine at moderate doses has been shown to facilitate memory acquisition and retention in animals assessed on various learning tasks. [110][111][112][113] A few articles have focused on the interaction between caffeine and ethanol on the memory in rodents. 114,115 Ethanol and caffeine coadministration has demonstrated to be 12 LÓ PEZ-CRUZ ET AL.…”

Brain-Choroid Plexus Chemistry Changes Linkable to Caffeine Ingestion and Accompanying Short-Term Memory Disturbances in Experimental Models

“…This result is very much supported by a review article written by Mohammad et al, 2014. In comparism with the control group, the caffeine treated groups as seen in Figure 3 was not statistically significant but mere looking at the graphs, the group that was administered high dose caffeine had a high total latency but not higher than the control group, this can be interpreted that the animals in this group had improved memory (short term) than the control group and this indicated that high dose of caffeine can enhance short term memory when taken for a long time, this result is supported by Angelucci et al, 2002. The group treated with low dose caffeine was also not statistically significant but had a smaller total latency when compared to the control group; it can be said that low dose consumption of caffeine also improves short term memory.…”