2002
DOI: 10.1590/s0100-879x2002000600013
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Abstract: We investigated the protective effect of suramin, an enzyme inhibitor and an uncoupler of G protein from receptors, on the myotoxic activity in mice of different crotalid snake venoms (A.c. laticinctus, C.v. viridis, C.d. terrificus, B. jararacussu, B. moojeni, B. alternatus, B. jararaca, L. muta). Myotoxicity was evaluated in vivo by injecting im the venoms (0.5 or 1.0 mg/kg) dissolved in physiological saline solution (0.1 ml) and measuring plasma creatine kinase (CK) activity. Two experimental approaches w… Show more

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Cited by 31 publications
(13 citation statements)
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“…components, just like in a bell-shaped curve where higher concentrations of fucCS decreases the efficiency of the complex, which has been observed previously with the natural sulfated polysaccharide fucoidan against cytotoxic and myotoxic activities of a group of PLA 2 myotoxins from crotaline snake venoms (Angulo and Lomonte, 2003). Inhibition of snake venom PLA2 and myotoxicity also occur with other polyanions like heparin (Melo et al, 1988(Melo et al, , 1993Calil-Elias et al, 2002b), fucoidan (Azofeifa et al, 2008), suramin (Arruda et al, 2002), as well as a synthetic coumestan (Melo et al, 2010). Histological study showed an intense presence of inflammatory cells, myonecrosis and edema in muscle exposed to B. jararacussu venom, which was prevented by treatment with fucCS.…”
Section: Discussionsupporting
confidence: 53%
“…components, just like in a bell-shaped curve where higher concentrations of fucCS decreases the efficiency of the complex, which has been observed previously with the natural sulfated polysaccharide fucoidan against cytotoxic and myotoxic activities of a group of PLA 2 myotoxins from crotaline snake venoms (Angulo and Lomonte, 2003). Inhibition of snake venom PLA2 and myotoxicity also occur with other polyanions like heparin (Melo et al, 1988(Melo et al, , 1993Calil-Elias et al, 2002b), fucoidan (Azofeifa et al, 2008), suramin (Arruda et al, 2002), as well as a synthetic coumestan (Melo et al, 2010). Histological study showed an intense presence of inflammatory cells, myonecrosis and edema in muscle exposed to B. jararacussu venom, which was prevented by treatment with fucCS.…”
Section: Discussionsupporting
confidence: 53%
“…[5][6][7][8][9][10][11][12][13][14] Suramin prevents the development of muscle necrosis induced by some snake venoms, since it inhibits the myotoxic and in vitro neuromuscular blocking activities of Lys49 phospholipases A 2 from Bothrops species. 15,16 Phospholipases A 2 (PLA 2 s: EC 3.1. 1.4) are key enzymes in the control, regulation, production and release of lipid mediator precursors that serve as messengers in fundamental, highly regulated processes such as growth, adhesion, apoptosis, secretion, hemostasis and immune regulation.…”
Section: Introductionmentioning
confidence: 99%
“…Metalloproteases of ECV induce myotoxicity, which is secondary to haemorrhage, characterized by elevated serum creatine kinase (CK) and lactate dehydrogenase (LDH) (Pierce et al 2011). One of the isoforms of these enzymes is abundantly present in the cytosolic compartment of skeletal muscles and is released into the circulation following skeletal muscle damage as observed in many clinical conditions including snakebite (Arruda et al 2002). ALME inhibited the myotoxicity induced by ECV significantly, evidenced by reduced serum CK (64%; p < 0.0001; ED 50 ¼ 37.5 lg) and LDH (64%; p ¼ 0.0021; ED 50 ¼ 31.44 lg) levels at the ratio 1:50 w/w upon co-injection (Figures 5 and 9).…”
Section: Resultsmentioning
confidence: 99%