2002
DOI: 10.1590/s0100-879x2002000600011
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Abstract: The venom of Lonomia obliqua caterpillar may induce a hemorrhagic syndrome in humans, and blood incoagulability by afibrinogenemia when intravenously injected in laboratory animals. The possible antithrombotic and thrombolytic activities of L. obliqua caterpillar bristle extract (LOCBE) were evaluated in this study. The minimal intravenous dose of the extract necessary to induce afibrinogenemia and anticoagulation was 3.0 and 10.0 µg protein/kg body weight for rabbits and rats, respectively. In rabbits, this d… Show more

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Cited by 23 publications
(20 citation statements)
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References 26 publications
(32 reference statements)
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“…Similar to the effect of L. achelous, the tests returned to normal values within 24-48 h [32]. Intravenous injections of Loche deplete Fg and FXIII, but do not induce lysis of preformed thrombi [35]. Intravenous injections of purified Lopap induce disseminated intravascular coagulation in rats [36].…”
Section: Obliquamentioning
confidence: 69%
“…Similar to the effect of L. achelous, the tests returned to normal values within 24-48 h [32]. Intravenous injections of Loche deplete Fg and FXIII, but do not induce lysis of preformed thrombi [35]. Intravenous injections of purified Lopap induce disseminated intravascular coagulation in rats [36].…”
Section: Obliquamentioning
confidence: 69%
“…It indicates that LOCBE did not contain enzymes capable of degrading cross-linked fi brin, reinforcing previous fi ndings which stated that the L. obliqua venom mainly exerts procoagulant activity causing a consumption coagulopathy leading to a hemorrhagic state induced by fi brinogen depletion and secondary fi brinolysis [1,4,5] . Corroborating with this hypothesis, in experimental thrombosis studies, Prezoto et al [8] have shown that while the streptokinase infusion in rats induced local thrombolysis, LOCBE promoted fi brinogen depletion and decreased thrombus size without inducing thrombolysis. In ad dition, it was also demonstrated that the infusion of Lopap, a prothrombin activator isolated from LOCBE, triggered in mice a condition similar to that of human poisoning [9] , indicating that procoagulant activities are the major biological effects of the bristles extract.…”
Section: Studies Related With the L Obliqua Human Envenomingmentioning
confidence: 87%
“…Fibrinolysis is present in all vertebrates but invertebrates generally only have clumping of blood corpuscles (Withers 1992). Vertebrates factors involved in coagulation and fibrinolysis have evolved from common ancestral proteins and fibrinolytic ones seem to be related to digestive proteolytic enzymes used by rudimentary microorganisms to be released and disseminated, avoiding the host´s nonspecific defense and immunity response (Patthy 1990 Insects have rich sources of pharmacological active substances that may have medical value: The venom of Lonomia oblique caterpillar may induce a hemorrhagic syndrome in humans, and blood incoagulability in laboratory animals (Prezoto et al 2002). Bee venom of Bombus ignites contains a Kunitz type serine protease inhibitor (Bi-KTI) that acts as an antifibrinolytic agent inhibiting plasmin (Choo et al 2012).…”
Section: Selection Of Animal Model In Fibrinolysis a Challengementioning
confidence: 99%