2001
DOI: 10.1590/s0100-879x2001000100001
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Abstract: Although cardiac ischemia is usually characterized as a disease of the myocyte, it is clear that the vasculature, and especially endothelial cells, is also a major target of this pathology. Indeed, using a rat model of ischemia/reperfusion, we were able to detect severe endothelial dysfunction (assessed as a decreased response to acetylcholine) after acute or chronic reperfusion. Given the essential role of the endothelium in the regulation of vascular tone, as well as platelet and leukocyte function, such a s… Show more

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Cited by 35 publications
(18 citation statements)
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References 31 publications
(32 reference statements)
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“…Experimental studies have shown that ischemic preconditioning induces the development of protected phenotypes in endothelial cells lining arterioles, capillaries, and venules. 18,[27][28][29][30][31][32] As a consequence of ischemic preconditioning, vasospasm and thrombosis are less likely to develop in arterioles, capillary perfusion deficits are reduced, and the inflammatory responses in the postcapillary venules are prevented. Thus, ischemic preconditioning could contribute to high MBG at risk area in AMI patients with PIA.…”
Section: Discussionmentioning
confidence: 99%
“…Experimental studies have shown that ischemic preconditioning induces the development of protected phenotypes in endothelial cells lining arterioles, capillaries, and venules. 18,[27][28][29][30][31][32] As a consequence of ischemic preconditioning, vasospasm and thrombosis are less likely to develop in arterioles, capillary perfusion deficits are reduced, and the inflammatory responses in the postcapillary venules are prevented. Thus, ischemic preconditioning could contribute to high MBG at risk area in AMI patients with PIA.…”
Section: Discussionmentioning
confidence: 99%
“…Few studies have shown a positive influence of IPC on restoration of cardiac contractile function (49). Protection against vascular dysfunction by IPC also remains controversial (50)(51)(52)(53), but several studies have shown that preconditioning pretreatment protects blood vessels and possibly the microcirculation against vascular stunning (54,55). The mechanisms that are responsible for cytoprotection against infarction and contractile or vascular stunning are not the same, and many of these mechanisms are believed to be shared.…”
Section: Myocardial Protectionmentioning
confidence: 99%
“…Endothelial dysfunction may also exacerbate tissue injury indirectly by increasing platelet -leukocyteendothelium interactions [3]. Therapeutic strategies aimed at improving endothelial function have been shown to markedly retard the development of atherosclerosis and attenuate vascular and tissue injury associated with ischemia/reperfusion [4]. Therefore, coronary endothelial protection is an early and effective therapeutic approach that may reduce subsequent cardiomyocyte injury.…”
Section: Introductionmentioning
confidence: 99%