Hepatic capillariasis in rats: a new model for testing antifibrotic drugs

Abstract

Rats infected with the helminth

Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

“…Its usefulness for testing antifibrotic drug has been demonstrated (Souza et al 2000(Souza et al , 2001. Several studies have been dedicated to the understanding of the pathogenesis of septal fibrosis.…”

Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)

“…It appears in 100% of the infected animals, and it is evident regardless the parasite load (Oliveira & Andrade 2001). Septal fibrosis extends from portal spaces, going toward neighboring portal spaces and central veins, finishing by involving the entire organ, thus creating a septate mosaic pattern (Ferreira & Andrade 1993, Souza et al 2000, 2001.…”

“…Actually, the C. hepatica and the pig-serum models are the two models of septal fibrosis being used in experimental investigations. C. hepatica-induced-septal fibrosis has been revealed as a good model for testing anti-fibrosis drugs and for studies on pathogenesis of hepatic fibrosis (Souza et al 2000, 2001, Santos et al 2001, Lemos et al 2003.…”

Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis

“…Of these 35 infected rats, 10 were maintained as infected-untreated controls and 25 were submitted to antihelminthic treatment. Data on egg acquisition and counting and inoculum preparation are described elsewhere 10 .…”