2000
DOI: 10.1590/s0100-879x2000001000001
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Abstract: The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH). Oxytocin may augment the release of ACTH under certain conditions, whereas atrial natriuretic peptide acts as a corticotropin release-inhibiting factor to inhibit ACTH release by direct action on the pituitary. Glucocorticoids act on their receptors within the hypothalamus and anterior pituitary gland to suppress the release of vasopressin and CRH and the release … Show more

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Cited by 55 publications
(33 citation statements)
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“…The CRH-propiomelanocortin system is highly organized, entrained, and of crucial importance for cutaneous responses to stress (4,(17)(18)(19). CRH activity on skin seems to depend on the cellular target.…”
Section: Discussionmentioning
confidence: 99%
“…The CRH-propiomelanocortin system is highly organized, entrained, and of crucial importance for cutaneous responses to stress (4,(17)(18)(19). CRH activity on skin seems to depend on the cellular target.…”
Section: Discussionmentioning
confidence: 99%
“…The concept that the endocrine function of the adrenals can be adequately interpreted by studying the functions of individual endocrine cells in isolation is useful but does not always reflect in vivo function (49). The intricate neuroendocrine communication between the HPA axis and the autonomic nervous system occurs at peripheral and central levels and is of relevance to clinical medicine (1,2,50,51). Patients with mutations in the TH gene (52,53) have recently been discovered, and there are many diseases associated with catecholamine depletion and͞or adrenomedullary impairment, including diabetes (54, 55), Addison's disease (56), 21-OH deficiency (7), and prenatal hypoxemia (57).…”
Section: Discussionmentioning
confidence: 99%
“…Glucocorticoids serve a number of important roles in mammalian physiology as they regulate glucose and fat metabolism, mediate stress responses, and influence the immune system, among other functions (McCann et al, 2000;Aguilera et al, 2007;Macfarlane et al, 2008;Vinson, 2009). The major murine glucocorticoid is corticosterone.…”
Section: Introductionmentioning
confidence: 99%