Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury

Corbel, M; Boichot, Elisabeth; Lagente, Vincent

doi:10.1590/s0100-879x2000000700004

Cited by 133 publications

(106 citation statements)

References 36 publications

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“…It degrades type IV collagen, proteoglycan, and laminin. MMP-9 is produced by tumoral cells as well as inflammatory cells such as neutrophil, eosinophil, monocyte, lymphocyte and alveolar macrophage (Chintala et al 1999;Corbel et al 2000;Apakkan Aksun et al 2001;Bayramoglu et al 2009Bayramoglu et al , 2011.…”

Section: Introductionmentioning

confidence: 99%

Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

et al. 2013

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The current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene and C677T of the methylenetetrahydrofolate reductase (MTHFR) gene. Genomic DNA obtained from 224 persons (125 patients with hypertension and 99 healthy controls) were used in the study. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism and electrophoresis. The results were statistically analyzed and were found to be statistically significant. The frequencies of the C1562T genotypes were found to be, in controls CC 75.8 % and CT 24.2 % and in patients CC 71.2 %, and CT 28.8 %. The frequencies of C677T genotype were found to be, in controls CC 56.6 %, CT 38.4 and TT 5.1 % in controls and in patients CC 52 %, CT 30.4 % and TT 17.6 %. In conclusion, we may suggest that there is no relation between the essential hypertension and C1562T polymorphism of MMP-9 gene; on the other hand C677T polymorphism (genotype TT) of MTHFR gene can be regarded as a genetic indicator for the development of essential hypertension.

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Section: Introductionmentioning

confidence: 99%

Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

et al. 2013

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“…MMP-2 and MMP-9 are known to degrade type IV collagen and gelatin, which are major components of the extracellular matrix (53)(54)(55). Their excess activity has been thought to contribute to the development of emphysema through extensive destruction of the extracellular matrix and remodeling of lung parenchyma (54,56,57). Therefore, we propose that the alveolar enlargement in Ig-Hepta Ϫ/Ϫ may result from the overactivation of the MMPs, which causes alveolar tissue destruction and remodeling.…”

Section: Discussionmentioning

confidence: 91%

Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation

Ariestanti

Ando

Hirose

et al. 2015

Journal of Biological Chemistry

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Background: Ig-Hepta knock-out mice exhibit emphysema-like symptoms, but their pathogenesis remains unclear. Results: In Ig-Hepta knock-out mice, alveolar macrophages are activated and release matrix metalloproteinases through reactive oxygen species-mediated nuclear factor-B activation. Conclusion: Ig-Hepta is likely to negatively regulate macrophage function and inflammation in the alveoli. Significance: These findings reveal a novel mechanism for maintaining lung homeostasis and immune regulation.

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“…Knockout mice showed significant reductions in the expression of macrophage inflammatory protein-1 alpha (MIP-1α), MIP-1β, and MCP [86]. Additionally, neutrophil and macrophages are known to activate the MMP-2 and -9 secretion [87,88]. However, addition of inflammatory cytokines to cells upregulates the expression of MMP-2 and -9 along with other various cytokines and chemokines, and administration of IL-1β to diabetic animal upregulates the expression of MMP-2 and -9.…”

Section: Mmps and Inflammationmentioning

confidence: 99%

Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy

Mohammad

Siddiquei

2012

j ocul biol dis inform

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Diabetic retinopathy represents the most common causes of vision loss in patients affected by diabetes mellitus. The cause of vision loss in diabetic retinopathy is complex and remains incompletely understood. One of the earliest changes in the development of retinopathy is the accelerated apoptosis of retinal microvascular cells and the formation of acellular capillaries by unknown mechanism. Results of a recent research suggest an important role of matrix metalloproteinases (MMPs) in the development of diabetic retinopathy. MMPs are a large family of proteinases that remodel extracellular matrix components, and under pathological condition, its induction is considered as a negative regulator of cell survival; and in diabetes, latent MMPs are activated in the retina and its capillary cells, and activation of MMP-2 and -9 induces apoptosis of retinal capillary cells. This review will focus on the MMP-2 and MMP-9 in the diabetic retina with special reference to oxidative stress, mitochondria dysfunction, inflammation and angiogenesis, as well as summarizing the current information linking these proteins to pathogenesis of diabetic retinopathy.

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Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury

Cited by 133 publications

References 36 publications

Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation

Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy

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