1997
DOI: 10.1590/s0100-879x1997000600014
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Abstract: We investigated the effects of piperitenone oxide (PO), a major constituent of the essential oil of Mentha x villosa, on the guinea pig ileum. PO (30 to 740 µg/ml) relaxed basal tonus without significantly alterating the resting membrane potential. In addition, PO relaxed preparations precontracted with either 60 mM K + or 5 mM tetraethylammonium in a concentration-dependent manner. At concentrations from 0.1 to 10 µg/ml PO potentiated acetylcholine-induced contractions, while higher concentrations (>30 µg/ml)… Show more

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Cited by 38 publications
(30 citation statements)
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“…In our laboratory, we have shown that the essential oil of M. x villosa (EOMV) blocks excitationcontraction coupling in skeletal muscle and causes contraction by releasing Ca 2+ from the sarcoplasmic reticulum (4). Piperitenone oxide (PO), the major constituent of EOMV, exerts an antispasmodic effect on the intestinal smooth muscle of guinea pigs (5). In conscious rats, intravenous administration of EOMV elicited immediate and dose-dependent decreases in mean aortic pressure and heart rate (6).…”
Section: Introductionmentioning
confidence: 99%
“…In our laboratory, we have shown that the essential oil of M. x villosa (EOMV) blocks excitationcontraction coupling in skeletal muscle and causes contraction by releasing Ca 2+ from the sarcoplasmic reticulum (4). Piperitenone oxide (PO), the major constituent of EOMV, exerts an antispasmodic effect on the intestinal smooth muscle of guinea pigs (5). In conscious rats, intravenous administration of EOMV elicited immediate and dose-dependent decreases in mean aortic pressure and heart rate (6).…”
Section: Introductionmentioning
confidence: 99%
“…Recently, we demonstrated that derivatives of monoterpenes also exhibit several types of pharmacological properties, such as antinociceptive De Sousa et al, 2004), sedative (De Sousa et al, 2006b) and antidepressant (De Sousa et al, 2006c). The essential oil of the plant Mentha ¥ villosa Hudson (Lamiaceae), popularly known as "hortelã -da-folha-miú da", has shown a central nervous system-depressant effect (Raya et al, 1990) (Guedes et al, 2004), antinociceptive (De Sousa et al, 2007b) and relaxant of intestinal smooth muscle (Sousa et al, 1997) effects. The main aim of the present study was to determine the relationship between the chemical structure of rotundifolone and its spasmolytic activity to understand the influence of the functional groups of this monoterpene.…”
Section: Introductionmentioning
confidence: 99%
“…The plant has many pharmacological activities: anti-parasitic, tranquilizer (central nervous system depressant), bradicardizant, anti-hypertensive, analgesic, relax smooth musculature and contract skeletal musculature (Almeida et al, 1996;Fogaça et al, 1997;Lahlou et al, 2001;2002a,ba,b;Sousa et al, 2009). An extract obtained from leaves present santispasmodic effect and is employed for the treatment of intestinal disorders caused by Giardia lamblia and Entamoeba histolytica (Santana et al, 1992;Sousa et al, 1997). Previous phytochemical analyses revealed the compounds 1,2-epoxipulegone-rotundifolone (main constituent), carvone, menthol, linalol, cineol, cetone, mentone, d-carvone, reduced quantities of mentonone, pipertinone, jasmone, acetic esters and mentone isovaleric, flavonoids, rosmarinic acid, luteoline, tannic acid and resine as constituents of it leaves.…”
Section: Research Articlementioning
confidence: 99%