BIOEFFICACY OF A COMMON WEED Datura metel AGAINST Colletotrichum gloeosporioides

Karim, M Abdel; Jabeen, Khajista; Iqbal, Sumera; Javaid, Arshad

doi:10.1590/s0100-83582017350100040

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Amides are abundant in D. metel seeds, and considered as characteristic components (Karim et al, 2017). Four major amides ( 1 , 18 , 22 , and 40 ) were chosen to examine the in vivo metabolism of this type of compounds.…”

Section: Resultsmentioning

confidence: 99%

Characterization of the Metabolic Fate of Datura metel Seed Extract and Its Main Constituents in Rats

Xia

Liu

et al. 2019

Front. Pharmacol.

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Datura metel L. has been frequently used in Chinese traditional medicine. However, little is known on the chemical composition and in vivo metabolism of its seeds. In this study, using the strategy “chemical analysis, metabolism of single representative compounds, and metabolism of extract at clinical dosage” that we propose here, 42 constituents were characterized from D. metel seeds water extract. Furthermore, the metabolic pathways of 13 representative bioactive compounds of D. metel seeds were studied in rats after the oral administration of D. metel seeds water extract at a clinical dosage (0.15 g/kg). These included three withanolides, two withanolide glucosides, four amides, one indole, one triterpenoid, one steroid, and one sesquiterpenoid, and with regard to phase II metabolism, hydroxylation, (de)methylation, and dehydrogenation reactions were dominant. Furthermore, the metabolism of D. metel seeds water extract provided to rats at a clinical dosage was investigated by liquid chromatography-tandem mass spectrometry based on the above metabolic pathways. Sixty-one compounds were detected in plasma, 83 in urine, and 76 in fecal samples. Among them, withanolides exhibited higher plasma exposure than the other types. To our knowledge, this is the first systematic study on the chemical profiling and metabolite identification of D. metel seeds, including all compounds instead of single constituents.

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Section: Resultsmentioning

confidence: 99%

Characterization of the Metabolic Fate of Datura metel Seed Extract and Its Main Constituents in Rats

Xia

Liu

et al. 2019

Front. Pharmacol.

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“…The chloroform fraction showed the best inhibition of the fungus. GC-MS analysis identified bioactive constituents i.e., n-hexadecanoic acid, phytol, octadecanoic acid, oleic acid, o-xylene and cyclohexanol 76 .…”

Section:  Effects On Medial Prefrontal Cortex Histologymentioning

confidence: 99%

Untitled

2020

IJPSR

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Plants have great potential for the treatment and management of many diseases and have been used in many countries for the treatment of different diseased conditions. The medicinal value of plants lies in their bioactive phytochemical constituents that produce definite physiological actions in living beings. Many medicinal plants contain some chemical constituents that may cause harmful effects to humans if consumed in large quantities. Alkaloids occurring in large amounts could make plants poisonous despite its medicinal effects. Datura metel L., a member of the family Solanaceae, is known as Jimson weed and in Arabic known as "Jaozmasel", is one of the well-known folk medicinal herbs with wide application, Chemical investigation of which revealed its components as alkaloids, carbohydrates, and proteins among which alkaloids including scopolamine, hyoscyamine and atropine are the main active ingredients that exhibits various activities, such as anti-asthmatic, sedative, analgesic and anti-rheumatoidal effects. Besides of medicinal usage, D. metel is one of the most abused plants all over the world because of its unrestricted availability, especially in Africa, Southeast Asia and in India, mainly for spiritual or religious purposes with negative reports are far more than other psychoactive substances. Its over-dose or abuse produced poisonous effects similar to anticholinergic, delirium, mydriasis, mental confusion, psychosis, and even violent behaviors. In this review, various interesting findings of the medicinal value of Datura metel has been mentioned, apart from its toxicity and ornamental importance to prove it as a potent chemotherapeutic agent. Thus concerted efforts in the relevant areas are still necessary to establish rational and to prevent sustainable exploitation of the world's biodiversity. INTRODUCTION:The universal role of plants in the treatment of disease is exemplified by their employment in all the major systems of medicine irrespective of the underlying philosophical premises.

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“…However, due to bad impact of synthetic chemicals on atmosphere, development of resistant mutants, more expensive pesticides and many health hazards (Westlund et al, 2018), such agrochemicals should be replaced with environmental friendly natural compounds . Numerous recent studies have shown that crude plant extract and isolated purified compounds from plants have tremendous potential in management of fungal plant pathogens Karim et al, 2017;Khurshid et al, 2017).…”

mentioning

confidence: 99%

Bioactive Constituents of Shoot Extracts of Sisymbrium irio L. Against Fusarium oxysporum f. sp. cepae

2020

Self Cite

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The present study was carried out to check the antifungal potential of Sisymbrium irio L. shoot extract against Fusarium oxysporum f. sp. cepae (FOC). In preliminary bioassays, different concentrations (1 to 5%) of leaf, stem and fruit extracts were evaluated against FOC. All the extracts were effective against the pathogen. However, the leaf extract was found the most effective causing 25-41% decrease in FOC biomass. The fractionation of methanolic leaf extract was done by two organic solvents namely n-hexane and chloroform. Different concentrations (1.56 to 200 mg mL-1) of these fractions were tested against FOC. The n-hexane and chloroform fractions showed inhibitory activity against the pathogen and resulted in 77-93% and 80-96% reduction in biomass of FOC, respectively. GC-MS analysis showed the presence of 24 compounds in n-hexane and 4 compounds in chloroform fraction. In n-hexane fraction, β-sitosterol (18.64%) was the most abundant compound followed by orotic acid, bis(tert-butyldimethylsilyl)-, tert-butyldimethylsilyl ester (12.18%), 10-octadecenoic acid, methyl ester (7.90%) and 1,2-benzenedicarboxylic acid, diisooctyl ester (6.05%). Major compounds identified in chloroform fraction were 1,3-benzenedicarboxylic acid, bis(2-ethylhexyl) ester (50.82%) and di-n-octyl phthalate (33.00%). This study concludes that n-hexane and chloroform fractions of methanolic leaf extract of S. irio contain potent antifungal constituents for the management of FOC.

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BIOEFFICACY OF A COMMON WEED Datura metel AGAINST Colletotrichum gloeosporioides

Cited by 6 publications

References 14 publications

Characterization of the Metabolic Fate of Datura metel Seed Extract and Its Main Constituents in Rats

Characterization of the Metabolic Fate of Datura metel Seed Extract and Its Main Constituents in Rats

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Bioactive Constituents of Shoot Extracts of Sisymbrium irio L. Against Fusarium oxysporum f. sp. cepae

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