Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)

Porsani, Mariana Yukari Hayasaki; Paludetti, Monique; Orlando, Débora Ribeiro; Peconick, Ana Paula; Costa, R. A.; Oliveira, Luiz Eduardo Duarte de; Zangerônimo, Márcio Gilberto; Sousa, Raimundo Vicente de

doi:10.1590/s0100-736x2017000900013

Cited by 4 publications

(4 citation statements)

References 37 publications

(66 reference statements)

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“…This proves that glutamine can reduce inflammatory reactions in the intestine, both in acute and chronic diarrhea. This result is supported by a study by Mariana et al in 2017 which induced inflammation in the intestines of rats with 15 mg/kg cytarabine commonly used as a therapy for leukemia and lymphoma in humans, the rats were then treated with glutamine therapy at a dose of 150 mg/kg/day for 21 days and the administration of glutamine was found to reduce inflammation and increase the immune response in the intestine [20].…”

Section: Discussionsupporting

confidence: 56%

The Effect of Glutamine Supplementation on Ileum Histopathology of Rats with Acute and Chronic EPEC-Induced Diarrhea

Putra

Oenzil

Darwin

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Glutamine is a non-essential amino acid as the main fuel in the gastrointestinal mucosa. By its various gastrointestinal functions, glutamine is thought to increase the protection of the intestinal mucosa against local or systemic injury from diarrhea. AIM: This study aims to determine the relationship between glutamine supplementation and ileum histopathology in rats with acute and chronic diarrhea induced by EPEC. MATERIAL AND METHODS: The research was conducted in an experimental laboratory with a randomized posttest-only control group design. A total of 30 Rattus novergicus strain Wistar were divided into 5 groups. The treatment group was induced to have diarrhea using EPEC at a dose of 108 CFU/ml, after each group diagnosed by acute and chronic diarrhea, followed by glutamine supplementation at a dose of 810 mg/200 g for 14 days. The intestinal histopathology of each group was assessed and their levels of inflammation classified based on the Barthel-Mandja inflammatory score. RESULT: The result showed that significant differences in inflammation levels between the negative control group, acute diarrhea group, chronic diarrhea group, acute diarrhea group with glutamine, and chronic diarrhea group with glutamine were found (p<0.05). The highest level of inflammation was found in the acute diarrhea group. CONCLUSION: This study concluded that glutamine supplementation has an effect on the ileum histopathology of rats with acute and chronic diarrhea. Keywords: Enteropathogenic E. Coli, Glutamine, gastrointestinal tract, pathology, ileum.

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Section: Discussionsupporting

confidence: 56%

The Effect of Glutamine Supplementation on Ileum Histopathology of Rats with Acute and Chronic EPEC-Induced Diarrhea

Putra

Oenzil

Darwin

et al. 2020

Open Access Maced J Med Sci

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“…Supplementation of beta-glucan and MOS from SCYS or YCWP improves mammary gland health in lactating animals [50,52,56,66]. Moreover, orally taking SCY-derived beta-glucan has been reported to influence the synthesis and release of interleukins IL-6 and IL-10 in vivo [98][99][100] and reduce blood IL-6 and increase blood IL-10 in overweight and obese people [101]. These cytokines were also detected in breast milk and may potentially regulate infant gut immunity [102], although no maternal supplementation studies have evaluated human milk cytokines.…”

Section: Hypotheses Of the Mechanism Of Saccharomyces Cerevisiae Yeast-based Supplement On Breast Milk Productionmentioning

confidence: 99%

Saccharomyces cerevisiae Yeast-Based Supplementation as a Galactagogue in Breastfeeding Women? A Review of Evidence from Animal and Human Studies

2021

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Perceived insufficient milk production (PIM) adversely affects breastfeeding duration. Women sometimes use galactagogues with the intent to increase breast milk production and support lactation. Saccharomyces cerevisiae yeast-based supplement (SCYS) is an inactive form of Saccharomyces cerevisiae yeast (SCY) either obtained from the fermentation process or grown on molasses. Anecdotal evidence suggests SCYS is a galactagogue. SCYS is promoted on the internet as a galactagogue in various forms and doses. Dietary supplementation with SCYS during gestation and lactation significantly increases milk yield in ruminants. No human study has evaluated efficacy of SCYS as a galactagogue. SCYS is rich in B vitamins, beta-glucan, mannan oligosaccharides and bioavailable chromium; these may impact breast milk production or composition, thus may alleviate PIM. The safety of taking SCYS during lactation is not well studied. Studies have reported contamination of SCYS with ochratoxin A (OTA) as well as minor side effects from SCYS. Studies are needed to evaluate the efficacy of SCYS on breast milk production and composition and to assess the safety of taking SCYS during lactation in humans.

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“…Previous research showed a decline in the levels of inflammatory cytokines, such as TNF‐α and IL‐10, in humans after surgery and supplemented with glutamine (Wilmore, 2001). In mice, pre‐treated orally with glutamine before a challenge, showed the IL‐10 blood levels did not change, despite increasing count of leucocytes in comparison to the group without treatment (Porsani et al., 2017). Although when evaluating this amino acid supplementation in human patients on post‐operative period, conflicting results were reported.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding supplementation with high concentrations of glutamine, no clinical research in dogs has been conducted. However, controversial results have been described in laboratory animals and human patients supplemented with this nutrient (Klek et al., 2008; Lu et al., 2011; Porsani et al., 2017; Wilmore, 2001). Previous research showed a decline in the levels of inflammatory cytokines, such as TNF‐α and IL‐10, in humans after surgery and supplemented with glutamine (Wilmore, 2001).…”

Section: Discussionmentioning

confidence: 99%

Effects of a diet enriched with eicosapentaenoic, docosahexaenoic and glutamine on cytokines as immunological markers for systemic inflammation in bitches before and after ovariohysterectomy

Porsani

Bonder

Teixeira

et al. 2019

Animal Physiology Nutrition

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The post‐operative period can generate immunological stress and can be modulated through supplementation with the omega‐3 series of polyunsaturated fatty acids. This study aimed to evaluate the effects of diets enriched with high doses of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids and glutamine on inflammatory mediators in dogs before and after ovariohysterectomy (OVH). Twelve female dogs were divided into two groups: group A was fed a commercial diet without the addition of EPA and DHA, and group B was fed an experimental diet enriched with EPA and DHA (0.2 g/100 kcal). Experimental diet intake initiated 21 days before surgery and continued until 30 days after OVH. Parameters measured were serum cytokines (TNF‐α, IL‐6 and IL‐10), C‐reactive protein (CRP), IGF‐1, lymphoproliferation and body composition before and after surgery. Statistical analyses were performed with SAS software considering the effects of age and diet and their interactions, and means were compared by the Tukey test. There was no difference between groups in body weight (p = .682), lean mass (p = .101) and body fat (p = .103). There were no group differences in serum concentrations of TNF‐α, IL‐6, IL‐10, IGF‐1, CRP and the percentage of lymphocyte proliferation. However, a time effect for TNF‐α was observed (p < .001), in which T0P (10 days after the surgical procedure) presented lower values of this cytokine when compared to the other evaluation time points; and interaction effects between group and time were observed for serum concentrations of IL‐6 (p < .001) and IL‐10 (p = .002). OVH procedure was not considered invasive enough to increase inflammatory cytokines after 30 days of surgery, as well as the dosage of the EPA and DHA used before and after the surgery did not modulate the inflammatory markers.

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Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)

Cited by 4 publications

References 37 publications

The Effect of Glutamine Supplementation on Ileum Histopathology of Rats with Acute and Chronic EPEC-Induced Diarrhea

The Effect of Glutamine Supplementation on Ileum Histopathology of Rats with Acute and Chronic EPEC-Induced Diarrhea

Saccharomyces cerevisiae Yeast-Based Supplementation as a Galactagogue in Breastfeeding Women? A Review of Evidence from Animal and Human Studies

Effects of a diet enriched with eicosapentaenoic, docosahexaenoic and glutamine on cytokines as immunological markers for systemic inflammation in bitches before and after ovariohysterectomy

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