2017
DOI: 10.1590/s0100-736x2017000900005
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Abstract: Sida carpinifolia poisoning causes a chronic neurodegenerative disorder associated with lysosomal storage by indolizidine alkaloids (swainsonine). The epidemiological, clinical, pathological and lectin histochemistry findings of an outbreak of natural poisoning by S. carpinifolia in horses in Rio Grande do Sul state, Brazil, are described. Five horses from a total of 15 that were kept on native pasture with large amounts of S. carpinifolia presented during 90 days clinical signs of progressive weight loss, inc… Show more

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Cited by 4 publications
(2 citation statements)
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“…The outbreaks of S. carpinifolia occurred in small properties where the plant invaded the paddocks and was predominant in some situations, which, associated with hunger, were essential factors for occurrence of the diseases. These conditions were also reported by Colodel et al (2002), Furlan et al (2009), and Bassuino et al (2017) in poisoning in goats, cattle, and horses, respectively. The clinical signs observed in bovines in outbreaks of S. carpinifolia and S. fastigiatum are characteristic of cerebellar lesion.…”
Section: Discussionsupporting
confidence: 69%
“…The outbreaks of S. carpinifolia occurred in small properties where the plant invaded the paddocks and was predominant in some situations, which, associated with hunger, were essential factors for occurrence of the diseases. These conditions were also reported by Colodel et al (2002), Furlan et al (2009), and Bassuino et al (2017) in poisoning in goats, cattle, and horses, respectively. The clinical signs observed in bovines in outbreaks of S. carpinifolia and S. fastigiatum are characteristic of cerebellar lesion.…”
Section: Discussionsupporting
confidence: 69%
“…Sida carpinifolia (family Malvaceae , subfamily Malvaceae ) is a small subshrub distributed throughout Brazil, mainly in humid and shaded areas in the south, southeast, and midwest regions. 11 S. carpinifolia poisoning has been reported in goats, 3 horses, 1,9 sheep, 18 cattle, 4 and deer. 13 This plant contains an indolizidine alkaloid (swainsonine) that inhibits α-mannosidase, a lysosomal enzyme, and thus induces the accumulation of mannose-containing oligosaccharides in the lysosomes of several cell types.…”
mentioning
confidence: 99%