2017
DOI: 10.1590/s0100-736x2017000300012
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Abstract: Stem cells are undifferentiated cells with a high proliferation potential. These cells can be characterized by their in vivo ability to self-renew and to differentiate into specialized cell lines. The most used stem cell types, in both human and veterinary fields, are the mesenchymal stem cells (MSC) derived from bone marrow and adipose tissue. Nowadays, there is a great interest in using stem cells derived from fetal tissues, such as amniotic membrane (AM) and umbilical cord tissue (UCT), which can be obtaine… Show more

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Cited by 13 publications
(9 citation statements)
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“…Mesenchymal stem cells (MSCs) are characterized by a multipotent cell lineage with a high capacity of differentiation into different cell types, which can execute trophic, paracrine, and immunomodulatory functions in other cells based on the microenvironment. 1,2 In regenerative medicine, MSCs derived from fetal annexes such as amniotic fluid, amniotic membrane, and umbilical cord blood and vessels have previously been isolated and well-characterized in humans 3 and other species, such as dogs, [4][5][6][7] cats, 8,9 bovines, 10 sheep, 11,12 horses, 13 rats, 14 rabbits, 15 and ducks, 16 suggesting the advantages of using it as raw material for the creation of cell banks. [17][18][19][20] Immunomodulatory activities occur through direct contact between the MSCs and tissues or through paracrine interaction mediated by interferon-gamma (IFN-γ), produced by the body's immune cells, which act on natural killer cells, monocytes, neutrophils, and macrophages.…”
Section: Introductionmentioning
confidence: 99%
“…Mesenchymal stem cells (MSCs) are characterized by a multipotent cell lineage with a high capacity of differentiation into different cell types, which can execute trophic, paracrine, and immunomodulatory functions in other cells based on the microenvironment. 1,2 In regenerative medicine, MSCs derived from fetal annexes such as amniotic fluid, amniotic membrane, and umbilical cord blood and vessels have previously been isolated and well-characterized in humans 3 and other species, such as dogs, [4][5][6][7] cats, 8,9 bovines, 10 sheep, 11,12 horses, 13 rats, 14 rabbits, 15 and ducks, 16 suggesting the advantages of using it as raw material for the creation of cell banks. [17][18][19][20] Immunomodulatory activities occur through direct contact between the MSCs and tissues or through paracrine interaction mediated by interferon-gamma (IFN-γ), produced by the body's immune cells, which act on natural killer cells, monocytes, neutrophils, and macrophages.…”
Section: Introductionmentioning
confidence: 99%
“…The growth factors produced by the amnion also stimulate cell proliferation and the synthesis of extracellular matrix (ECM) components. [ 14 ]…”
Section: Discussionmentioning
confidence: 99%
“…In addition, BSA contains extracellular metrics which increase chemotactic macrophage activity thus accelerating the release of PDGF and EGF, which can also accelerate fibroblast migration. [ 14 ]…”
Section: Discussionmentioning
confidence: 99%
“…bBM‐MSCs have a post thaw viability of 86.5% and thus, are feasible for cryopreservation (Okamura et al, ). UCT‐MSCs post cryopreservation may show viability of 80% (Campos et al, ). The viability is better with higher concentration of FBS (25%) than with the lower (15% and 20%) concentration (Singh, Mann, Kumar, Duhan, & Yadav, ).…”
Section: In Vitro Studiesmentioning
confidence: 99%