C-Peptides for diagnostics and therapy: a veterinary medicine point of view

Abstract

Empirical studies proved that C-peptides are performing numerous intrinsic biological roles, and serve as a marker for pancreatic performance analysis. Since the last decade, C-peptide assays for differential diagnosis in veterinary diabetic patients are becoming more available, but still only for a very limited number of species. Studies on C-peptide as a diagnostic tool, therapy for associated complications, or as replacement therapies for C-peptide deficiency still showed not to be a common practice in veterinary medicine. This review was conducted to determine the potential importance of C-peptide in Veterinary Medicine, relevant in the diagnosis of diabetes and for other metabolic processes, as well as its proposed therapeutic benefits. Numerous articles were identified that reported positive results in their experimental studies, whether C-peptide as a biomarker for pancreatic performance in dogs, cats, and horses, as a non-invasive method to monitor nutritional status in primates, or to investigate its potential therapeutic benefits for diabetes-related illnesses.

Energetics at the urban edge: Environmental and individual predictors of urinary C-peptide levels in wild chacma baboons (Papio ursinus)

“…Work comparing the amino acid sequences of C-peptides obtained from the pancreas of various mammal taxonomic families found that while the sequences vary, several prominent features of the C-peptide structures are preserved (Peterson et al, 1972; see also Landreh et al, 2014, Wahren 2004). Moreover, C-peptide has been successfully measured in the blood of domestic animals (dog, cat, horse; reviewed by Rosenfield et al, 2017). Together, these findings provide a promising basis for uCP measurements in non-primate mammals and future studies should validate existing immunoassays.…”

“…1:1) basis to insulin and, in addition to serving as a diagnostic tool for assessing pancreatic function in humans and domestic animals (for reviews see e.g. Leighton et al, 2017;Rosenfield et al, 2017), can be used as a proxy for nutritional status or energy balance (Emery Thompson, 2016). C-peptide is excreted at a consistent rate into urine and, in contrast to insulin, can be assessed from urine samples, enabling the repeated and non-invasive assessment of energetic condition (Emery Thompson, 2016), even in wild study populations.…”

Application of Peptide for Improving Animal Health and Livestock Productivity

“…Uji peptida C untuk diferensial diagnosis pada hewan terkena diabetes telah tersedia dalam dekade terakhir, meskipun masih terbatas beberapa spesies (Rosenfield et al 2017). Peptida C telah digunakan secara luas untuk mengukur fungsi sel beta pankreas.…”

“…Tingkat penurunan konentrasi peptida C menggambarkan tingkat kerusakan pada sel beta pankreas (Ghorbani & Shafiee-Nick 2015). Rosenfield et al (2017) melaporkan bahwa peneliti telah berhasil membuat klon dan ekpresi gen pro-insulin pada anjing dan menggunakannya sebagai diagnosis standar untuk uji pro-insulin pada anjing. Protein hasil ekspresi tersebut dapat digunakan sebagai marker untuk mengidentifikasi disfungsi sel beta pada anjing.…”