Uso de antimicrobiano nanoparticulado para o tratamento da mastite subclínica de ovelhas de corte no período seco

Santana, R. C. M.; Zafalon, L. F.; Brandão, Humberto M.; Júnior, Guilherme Aparecido Fim; Pilon, L. E.; Júnior, Waldomiro Barioni; Giglioti, Rodrigo; Mosqueira, Vanessa Carla Furtado

doi:10.1590/s0100-736x2016000900006

Cited by 5 publications

(3 citation statements)

References 19 publications

(14 reference statements)

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“…Parenteral administration of drug-loaded pbENPs in mastitic cows, sheep, or goats [114] could increase the risk for consumers through milk consumption as compared to non-nano delivery methods, where residue elimination time is clearly established. Other examples include a product that was approved for livestock use by UE's Committee for Medicinal Products for Veterinary Use (CVMP) in 2015 and by the US Food and Drug Administration (FDA) in 2016.…”

Section: Hormone Loaded Pbenpsmentioning

confidence: 99%

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

et al. 2021

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The field of veterinary medicine needs new solutions to address the current challenges of antibiotic resistance and the need for increased animal production. In response, a multitude of delivery systems have been developed in the last 20 years in the form of engineered nanoparticles (ENPs), a subclass of which are polymeric, biodegradable ENPs, that are biocompatible and biodegradable (pbENPs). These platforms have been developed to deliver cargo, such as antibiotics, vaccines, and hormones, and in general, have been shown to be beneficial in many regards, particularly when comparing the efficacy of the delivered drugs to that of the conventional drug applications. However, the fate of pbENPs developed for veterinary applications is poorly understood. pbENPs undergo biotransformation as they are transferred from one ecosystem to another, and these transformations greatly affect their impact on health and the environment. This review addresses nanoparticle fate and impact on animals, the environment, and humans from a One Health perspective.

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Section: Hormone Loaded Pbenpsmentioning

confidence: 99%

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

et al. 2021

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“…These findings suggest that the nanoencapsulation of toltrazuril made it possible to halve its dose for the treatment of coccidiosis, since the same response was observed in comparison with the reference medicine. In this context, the ability of nanoencapsulation to reduce drug dose was already evidenced in other studies, such as for PCL nanocapsules containing curcumin in the treatment of glioma in rats [27] and cloxacillin in the treatment of mastitis in sheep [38]. Moreover, to the best of our knowledge, this is the first report that evaluated polymeric nanocapsules containing an anticoccidial drug (toltrazuril), being a promising approach for the prophylactic control of Eimeria spp.…”

Section: Mucosal Sample Analysismentioning

confidence: 52%

Toltrazuril-Loaded Polymeric Nanocapsules as a Promising Approach for the Preventive Control of Coccidiosis in Poultry

et al. 2022

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Coccidiosis is a disease caused by intracellular protozoan parasites of the genus Eimeria that affect the intestinal tract of poultry. However, strain resistance and drug residue in the carcass have drawn the attention of the productive sector. The nanotechnology can improve the biological effect of drugs, reducing of administered doses and toxic effects. Due to this, toltrazuril-load polymeric nanoparticles based on Eudragit® S100 (NCt) or poly-ε-caprolactone (LNCt) were developed to prevent coccidiosis in broilers. Nanoformulations were produced and showed homogeneous particle diameter distribution in the nanometer range (z-average and D (4.3) < 200 nm), negative zeta potential (<−8.93 mV), drug content ~100%, and encapsulation efficiency >90%. Cell viability assays using avian fibroblasts showed that LNCt presented no relevant toxicity up to 72 h. LNCt was then prophylactically administrated to chicken followed by challenge with Eimeria oocysts. The evaluation of the small intestine and cecum showed that the treatment with LNCt (3.5 mg/kg/day) in drinking water reduced the lesion scores and oocysts excretion, similar to the reference medicine containing toltrazuril (Baycox®, 7 mg/kg/day). The current study shows the potential protective use of nanoencapsulating anticoccidial drugs as a promising approach for the control of coccidiosis in poultry.

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“…De acordo com Santana et al (2016) o processo inflamatório na glândula mamária desencadeado em resposta a um microrganismo invasor pode ser efetivo no combate à infecção, mas como esse efeito não é o suficiente para todos os casos, a medida mais comum no controle da mastite é o tratamento com antimicrobianos (Almeida et al, 1999).…”

Section: Mastiteunclassified

Uso de medicamentos homeopáticos para el tratamiento de la mastitis bovina: Revisión

Jesus¹,

Coutinho²

2018

Pubvet

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RESUMO.A mastite se apresenta como a doença de maior importância em vacas de leite, devido aos prejuízos causados pela perda de produtividade e descarte de leite de acordo com alguns tratamentos, como os antimicrobianos. Diante da problemática dos antibióticos pela má aplicação ou resistência bacteriana, uma alternativa para o controle da mastite é o uso da homeopatia. O objetivo do presente trabalho é informar o que já foi pesquisado sobre o uso de medicamentos homeopáticos para o tratamento da mastite. A terapêutica homeopática se enquadra nos preceitos da pecuária orgânica, sendo um método adequado para essa finalidade. Os remédios utilizados para o tratamento da doença são das mais variadas origens, de plantas, minerais, animais e de grande representatividade, de isolados ou compostos bacterianos, de microrganismos que são causadores da mastite. A facilidade de administração dos medicamentos homeopáticos se apresenta como uma grande vantagem, pois na forma mais comum de uso, o mesmo pode ser adicionado na água de bebida ou misturado na ração evitando estresse por parte do animal. Os resultados na mastite devido à aplicação da homeopatia podem ser visualizados na variação da contagem de células somáticas, reações no teste CMT (Califórnia Mastite Teste), ausência de isolamento de microrganismos do leite e diminuição da porcentagem de casos de mastite clínica e subclínica. Embora o tratamento homeopático se mostre uma ótima alternativa para o controle e tratamento da mastite, os resultados são bastante variáveis devido às diferentes metodologias empregadas e o grande número de medicamentos homeopáticos diferentes utilizados.Palavras chave: homeopatia, mastite, medicina alternativa, tratamento, vacas de leite Use of homeopathic medicines for the treatment of bovine mastitis: Review ABSTRACT. Mastitis presents as the most important disease in milk cows, due to the damages caused by loss of productivity and milk discharge according to some treatments, such as antimicrobials. Faced with the problem of antibiotics due to poor application or bacterial resistance, an alternative for the control of mastitis is the use of homeopathy. The aim of the present study is to inform what has already been researched about the use of homeopathic medicines for the treatment of mastitis. Homeopathic therapy fits within the precepts of organic farming, being a suitable method for this purpose. The remedies used for the treatment of the disease are from the most diverse origins, plants, minerals, animals and of great representatively, of isolates or bacterial compounds, of microorganisms that are the cause of mastitis.

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Uso de antimicrobiano nanoparticulado para o tratamento da mastite subclínica de ovelhas de corte no período seco

Cited by 5 publications

References 19 publications

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

Toltrazuril-Loaded Polymeric Nanocapsules as a Promising Approach for the Preventive Control of Coccidiosis in Poultry

Uso de medicamentos homeopáticos para el tratamiento de la mastitis bovina: Revisión

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