Arquitetura comparativa dos pulmões de camundongos normais e afetados pela Distrofia Muscular de Duchenne

Lessa, Thais Borges; Abreu, Dilayla Kelly de; Bertassoli, Bruno Machado; Ambrósio, Carlos Eduardo

doi:10.1590/s0100-736x2015001300010

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…They also resembled those of surface-and underground dwelling rodents 114,115 . The undivided left lung of C. gambianus, which was also reported in the same rodent by Ibe et al 60 , and the existence of three lobes on the left lung of C. foxi are not unique morphological features: various permutations in the lobulations of the lung occur in the mammalian lungs 61,62,113,[116][117][118][119][120][121] . Ostensibly, there is no evidence showing that lobulation of the lung is of functional consequence [122][123][124][125][126][127][128][129][130][131][132][133][134] .…”

Section: Discussionsupporting

confidence: 56%

Comparative morphometric analysis of lungs of the semifossorial giant pouched rat (Cricetomys gambianus) and the subterranean Nigerian mole rat (Cryptomys foxi)

Maina

Igbokwe

2020

Sci Rep

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Lungs of the rodent species, the African giant pouched rat (Cricetomys gambianus) and the nigerian mole rat (Cryptomys foxi) were investigated. Significant morphometric differences exist between the two species. The volume of the lung per unit body mass was 2.7 times larger; the respiratory surface area 3.4 times greater; the volume of the pulmonary capillary blood 2 times more; the harmonic mean thickness of the blood-gas (tissue) barrier (τht) ~29% thinner and; the total pulmonary morphometric diffusing capacity (DLo 2) for o 2 2.3 times more in C. foxi. C. gambianus occupies open burrows that are ventilated with air while C. foxi lives in closed burrows. the less morphometrically specialized lungs of C. gambianus may be attributed to its much larger body mass (~6 times more) and possibly lower metabolic rate and its semifossorial life whereas the 'superior' lungs of C. foxi may largely be ascribed to the subterranean hypoxic and hypercapnic environment it occupies. Compared to other rodents species that have been investigated hitherto, the τht was mostly smaller in the lungs of the subterranean species and C. foxi has the highest mass-specific DLo 2. the fossorial-and the subterranean rodents have acquired various pulmonary structural specializations that relate to habitats occupied. About 300 of the extant mammalian species that represent 54 genera and belong to 10 families of four orders live in moist and dark, climatically stable, hypoxic and hypercapnic underground burrows 1-8. Such animals inform on the natural evolutionary process of adaptation that has permitted underground life 9. In synapsids, the lineage that includes modern mammals and their ancestors 10,11 , the extinct mammal-like carnivore, the Cynodont (Thrinaxodon liorhinus) which inhabited the Karoo of South Africa ~251 million years ago (mya), is apparently the oldest known burrowing animal 12. Independently and at different amounts of time, animals invaded the underground ecotope, mostly between the upper Eocene (45-35 mya) and the Quaternary (~2 mya), when the global climate changed markedly to a colder and drier Earth 8,9,13-17. Predator avoidance, escape from extreme environmental conditions above the ground and gaining access to the subterranean parts of plants like roots, tubers, bulbs and corms and soil invertebrates were the main driving pressures for relocating to underground life. Extremophiles are life forms that have adapted to inhabiting exceptionally exacting conditions which are injurious to conventional living things 18-21. The hypoxic-and hypercapnic conditions in the unventilated, perpetually dark burrows that subterranean animals inhabit, where air may also contain noxious gases like ammonia and methane in high concentrations 22-30 , comprise extreme habitats. Of the ~250 species that occupy or take shelter in burrows, only ~25 species, most of which are mole rats of the Family Talpidae, permanently live underground 31-36. Because they are concealed and most of them pose a challenge of keeping and breeding them in the labor...

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Section: Discussionsupporting

confidence: 56%

Comparative morphometric analysis of lungs of the semifossorial giant pouched rat (Cricetomys gambianus) and the subterranean Nigerian mole rat (Cryptomys foxi)

Maina

Igbokwe

2020

Sci Rep

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“…The presence of leukocyte infiltrates in the liver, congestion in the alveolar septa and transudate with leukocyte infiltration in the lungs indicate inflammatory processes in these organs caused by MAEON and MBEON [ 101 ]. However, the literature has suggested that the application of insecticidal nano-emulsion in non-target mammals is safe [ 102 ].…”

Section: Discussionmentioning

confidence: 99%

Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae

et al. 2021

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Ayapana triplinervis is a plant species used in traditional medicine and in mystical-religious rituals by traditional communities in the Amazon. The aim of this study are to develop a nano-emulsion containing essential oil from A. triplinervis morphotypes, to evaluate larvicidal activity against Aedes aegypti and acute oral toxicity in Swiss albino mice (Mus musculus). The essential oils were extracted by steam dragging, identified by gas chromatography coupled to mass spectrometry, and nano-emulsions were prepared using the low energy method. Phytochemical analyses indicated the major compounds, expressed as area percentage, β-Caryophyllene (45.93%) and Thymohydroquinone Dimethyl Ether (32.93%) in morphotype A; and Thymohydroquinone Dimethyl Ether (84.53%) was found in morphotype B. Morphotype A essential oil nano-emulsion showed a particle size of 101.400 ± 0.971 nm (polydispersity index = 0.124 ± 0.009 and zeta potential = -19.300 ± 0.787 mV). Morphotype B essential oil nano-emulsion had a particle size of 104.567 ± 0.416 nm (polydispersity index = 0.168 ± 0.016 and zeta potential = -27.700 ± 1.307 mV). Histomorphological analyses showed the presence of inflammatory cells in the liver of animals treated with morphotype A essential oil nano-emulsion (MAEON) and morphotype B essential oil nano-emulsion (MBEON). Congestion and the presence of transudate with leukocyte infiltration in the lung of animals treated with MAEON were observed. The nano-emulsions containing essential oils of A. triplinervis morphotypes showed an effective nanobiotechnological product in the chemical control of A. aegypti larvae with minimal toxicological action for non-target mammals.

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“…It occurs due to a mutation in the gene that encodes dystrophin, which is the second largest protein in the human body and occurs in the sarcolemma. Dystrophin is located on the cytoplasmic face of skeletal and cardiac muscle membrane and constitutes approximately 5% of sarcolemmal cytoskeletal protein .…”

mentioning

confidence: 99%

Evaluation of the gastrointestinal tract in mdx mice: an experimental model of Duchenne muscular dystrophy

Feder

Ierardi

Covre

et al. 2018

APMIS

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This study describes the functional and morphological alterations in the intestines of mdx mice (n = 4) compared with the intestinal features of C57BL/10 mice (n = 7) at 2 months of age. The whole gut transit time (carmine red) and the upper gut transit time (activated charcoal) were measured, and light microscopy was utilized to view stained sections (H&E and picrosirius red) for histological analysis. No significant difference in mean evacuation time for the whole gut was observed between the two groups, but a significant delay in activated charcoal passage was observed in the mdx mice. Visually, a higher concentration of collagen fibers in the submucosal region was apparent in the mdx mice. The concentration of collagen fibers in the stomach and small intestine suggests a direct relationship with the decrease in motility of the upper gastrointestinal tract in the mdx mice. Further experimental studies should be conducted to develop therapeutic alternatives to collagen inhibition to control these manifestations.

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Arquitetura comparativa dos pulmões de camundongos normais e afetados pela Distrofia Muscular de Duchenne

Cited by 4 publications

References 26 publications

Comparative morphometric analysis of lungs of the semifossorial giant pouched rat (Cricetomys gambianus) and the subterranean Nigerian mole rat (Cryptomys foxi)

Comparative morphometric analysis of lungs of the semifossorial giant pouched rat (Cricetomys gambianus) and the subterranean Nigerian mole rat (Cryptomys foxi)

Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae

Evaluation of the gastrointestinal tract in mdx mice: an experimental model of Duchenne muscular dystrophy

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