2014
DOI: 10.1590/s0100-736x2014000500010
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Abstract: Dermatosparaxia em animais é uma doença autossômica recessiva do tecido conjuntivo caracterizada por fragilidade e hiperextensibilidade cutânea. A doença em ovinos White Dorper é provocada pela mutação c.421G>T no gene ADAMmetalopeptidase com trombospondina tipo 1 motif, 2 (ADAMTS2). O objetivo deste estudo foi descrever os achados clínicos, moleculares e histopatológicos da dermatosparaxia em ovinos White Dorper de um rebanho localizado no Centro-Oeste Paulista. O rebanho era composto por nove animais, sen… Show more

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Cited by 5 publications
(6 citation statements)
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References 16 publications
(23 reference statements)
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“…Genomic DNA was extracted from blood samples with the GenElute™ Genomic Blood DNA Kit (Sigma-Aldrich ® ) according to the manufacturer's instructions. PCR was performed using specific primers that amplify a 231-bp fragment containing the c.421G>T mutation in the ADAMTS2 gene based on a previously described method (Andrade et al 2014). The PCR products were analyzed by 1.5% agarose gel electrophoresis.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…Genomic DNA was extracted from blood samples with the GenElute™ Genomic Blood DNA Kit (Sigma-Aldrich ® ) according to the manufacturer's instructions. PCR was performed using specific primers that amplify a 231-bp fragment containing the c.421G>T mutation in the ADAMTS2 gene based on a previously described method (Andrade et al 2014). The PCR products were analyzed by 1.5% agarose gel electrophoresis.…”
Section: Methodsmentioning
confidence: 99%
“…Dermatosparaxis has previously been described in many species, including cattle (Kawaguchi et al 1988), horses (White et al 2004), dogs (Paciello et al 2003), cats (Sequeira et al 1999), and rabbits (Sinke et al 1997). The disorder occurs predominately in White Dorper sheep and has been reported in South Africa (van Halderen & Green 1988), Australia (Aggs 2007), Spain (Sucupira et al 2009), New Zealand (Vaatstra et al 2011), the United States (Grant and Patton 2012) and Brazil (Andrade et al 2014, Silva et al 2015. However, other breeds may also be affected (Fjølstad & Helle 1974, Ramshaw et al 1983, Van Weeren-Keverling & Koeman 1986, Monteagudo et al 2015.…”
Section: Introductionmentioning
confidence: 97%
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“…A fim de se evitar infecção secundária, foi instituído tratamento sistêmico com antibiótico à base de penicilina potássica 1 (dose: 30.000 U.I./ Kg), suplementação parenteral de glicose 2 (0,5 g/Kg) e sais minerais e complexos vitamínicos (Bioxan®) 1 , além de Maxicam® 1 (0,5 mg/Kg por via intravenosa; SID) e soro antitetânico 3 (5.000 U.I.). O tratamento tópico foi realizado com a lavagem com solução degermante de clorexidina 2% 2 e pomada à base de sulfadiazina de prata 2 . Após cinco dias de internação e tratamento, as lesões de pele não apresentaram melhora e novas lesões surgiram durante o manejo das feridas.…”
Section: Casounclassified
“…Sinais clínicos e estudos histopatológicos da estrutura do colágeno são importantes para identificar esta doença [16], porém os estudos moleculares permitem confirmar o diagnóstico da doença [2].…”
Section: Introductionunclassified