Doença de depósito lisossomal induzida pelo consumo de Ipomoea verbascoidea (Convolvulaceae) em caprinos no semiárido de Pernambuco

D., Lima, D.; Albuquerque, Raquel F.; Rocha, Brena P.; Barros, Maria Edna Gomes de; Gardner, Dale R.; Medeiros, Rosane M.T.; Riet-Correa, Franklin; Mendonça, Fábio de Souza

doi:10.1590/s0100-736x2013000700007

Cited by 10 publications

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References 14 publications

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“…verbascoidea) (Mendonça et al 2012, Rocha et al 2016, Simão-Bianchini & Ferreira 2015. Ipomoea sericosepala has been reported as toxic to goats, cattle and horses (Dantas et al 2007, Assis et al 2010, Oliveira Júnior et al 2013) and I. brasiliana so far has only been reported as important to goats (Mendonça et al 2012, Lima et al 2013. In previous studies, in both I. sericosepala and I. brasiliana significant amounts of swainsonine and calystegines were detected.…”

Section: Discussionmentioning

confidence: 95%

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Detection of swainsonine and calystegines in Convolvulaceae species from the semiarid region of Pernambuco

et al. 2018

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Animais de Produção/Livestock Diseases RESUMO.-[Detecção de swainsonina e calisteginas em espécies de Convolvulaceae da região semiárida de Pernambuco.] Numerosas espécies de plantas em todo o mundo, incluindo algumas espécies de Ipomoea (Convolvulaceae) e Sida (Malvaceae) no Brasil, causam doença de armazenamento lisossomal em herbívoros e são conhecidas por conterem swainsonina e calisteginas como princípios tóxicos. O objetivo deste trabalho foi determinar a concentração de swainsonina e calisteginas em espécies de Convolvulaceae da região semiárida de Pernambuco. Sete municípios na região do Sertão do Moxotó foram visitados, onde foram coletadas amostras das folhas de nove espécies de Convolvulaceae para avaliação da presença de swainsonina e calisteginas utilizando-se cromatografia líquida com espectrometria de massa. A presença e concentração destes alcaloides nas folhas de plantas da mesma espécie e dentre as espécies foram muito variáveis. Seis novas espécies de Ipomoea e uma espécie de Jacquemontia contendo swainsonina e/ou calisteginas são relatadas neste ABSTRACT. -Mendonça F.Numerous plant species worldwide including some Ipomoea (Convolvulaceae) and Sida (Malvaceae) species in Brazil cause lysosomal storage disease in herbivores and are known to contain swainsonine and calystegines as the main toxic compounds. The aim of this work was to determine swainsonine and calystegines concentrations in species of Convolvulaceae from the semiarid region of Pernambuco. Seven municipalities in the Moxotó region were visited and nine species were collected and screened for the presence of swainsonine and calystegines using an HPLC-APCI-MS method. The presence and concentration of these alkaloids within the same and in different species were very variable. Seven species are newly reported here containing swainsonine and/or calystegines. Ipomoea subincana contained just swainsonine. Ipomoea megapotamica, I. rosea and Jacquemontia corymbulosa contained swainsonine and calystegines. Ipomoea sericosepala, I. brasiliana, I. nil, I. bahiensis and I. incarnata contained just calystegines. The discovery of six Ipomoea species and one Jacquemontia species containing toxic polyhydroxy alkaloids reinforces the importance of this group of poisonous plants to ruminants and horses in the semiarid region of Pernambuco. Epidemiological surveys should be conducted to investigate the occurrence of lysosomal storage disease associated to these new species.

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Section: Discussionmentioning

confidence: 95%

“…After the falls, the animals have difficulty into raising up and may present spasticity of the hindlimbs. Other alterations, such as somnolence, progressive emaciation and bristly, brittle and opaque hair may be observed (Tokarnia et al 2012, Mendonça et al 2011, 2012, Lima et al 2013, Oliveira Júnior et al 2013, Rocha et al 2016.…”

Section: Introductionmentioning

confidence: 99%

Detection of swainsonine and calystegines in Convolvulaceae species from the semiarid region of Pernambuco

et al. 2018

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“…In Brazil, other diseases produce neurological clinical signs in cattle, such as poisoning by I. asarifolia (Döbereiner et al 1960), I. carnea sub. fistulosa (Antoniassi et al 2007), I. riedelli, I. sericophylla (Barbosa et al 2007), I. verbascoidea (Lima et al 2013), S. paniculatum (Guaraná et al 2011), and Turbina cordata (Dantas et al 2007). In other countries, Swainsonina, Oxitropis, and Astragalus have been described as causing lysosomal storage diseases (James et al 1981, Smith 2006).…”

Section: Unchanged Unchangedmentioning

confidence: 99%

Neurological diseases in cattle caused by plants and mycotoxins in Santa Catarina state, Brazil

et al. 2019

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This study described the epidemiological and clinical-pathological aspects of 25 outbreaks of neurological diseases in cattle caused by plants and mycotoxins in Santa Catarina state. Six of them were due to Sida carpinifolia poisoning, five to Solanum fastigiatum, five to Phalaris angusta, three to Claviceps paspali, three to Claviceps purpurea, and three outbreaks were of unknown etiology. The clinical signs observed in the affected cattle were mild to severe and characterized by generalized muscle tremors, incoordination, hypermetria, wide-based stance, intentional head tremors, dull staring eyes, and frequent ear twitching, with convulsions in some cases. At necropsy, lesions were observed only for P. angusta poisoning, characterized by gray-greenish discoloration in thalamus and midbrain. Microscopically, rarefaction and/or disappearance of Purkinje neurons with substitution by Bergmann cells were observed for S. carpinifolia and S. fastigiatum poisoning. For P. angusta poisoning, thin granular brown-yellowish pigment was observed in the cytoplasm of some neurons. Gross and microscopic findings were not observed in three outbreaks of tremorgenic disease of unknown etiology. Experiments conducted with leaves, flowers and seeds of Ipomoea indivisa and Ipomoea triloba, as well as with maize and soybean residues contaminated with Ipomoea spp. did not reproduced clinical signs.

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“…Although several species of the Convolvulaceae family are nontoxic and important fodder plants widely used for animal feeding (Cook et al 2013), many toxic plants belonging to this family, especially those in the Ipomoea genus, have been reported causing disease and significant economic losses to livestock production in the Brazilian semiarid region (Mendonça et al 2011, Oliveira et al 2011, Tokarnia et al 2012, Lima et al 2013, Oliveira et al 2013. There are no reports of poisoning by Merremia species in ruminants in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous and experimental poisoning by Merremia macrocalyx (Convolvulaceae) in cattle

et al. 2019

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The aim of this work was to describe the epidemiological, clinical and pathological aspects of spontaneous poisoning by Merremia macrocalyx in cattle in the Pernambuco state, northeastern Brazil, and to experimentally replicate the poisoning by this plant. To determine the occurrence of poisonings, 30 farms were visited in six municipalities at the Forest Zone of Pernambuco. The plant was found in nine farms, in which history of plant poisoning in cattle, and occasionally in sheep were also reported. Three outbreaks of spontaneous poisonings in cattle were studied. To replicate the disease experimentally, two steers received a single dose of 60g/kg and two steers received 80g/kg of the fresh leaves of M. macrocalyx in the trough for spontaneous ingestion. Two steers were also used as a control group. The main clinical signs observed in spontaneous cases consisted of restlessness, bloat, polyuria, diarrhea, and death within 48 to 72 hours after the onset of clinical signs. Cattle experimentally poisoned presented similar clinical signs to those observed in spontaneous cases. Gross lesions consisted of dryness and impaction of the rumen, omasum and reticulum contents. Abomasal content was fluid, the mucosa was hyperemic, with swollen folds and multiple ulcers. Similar lesions were observed in duodenum mucosae. Histologically, lesions observed in the abomasum and duodenum mucosa consisted of necrosis, hemorrhage and inflammatory infiltration of neutrophils and lymphocytes. The wide distribution and palatability of this plant, associated with the high sensitivity of the bovine species verified in this experiment, highlight the importance of this plant in spontaneous cases of poisoning in cattle.

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Doença de depósito lisossomal induzida pelo consumo de Ipomoea verbascoidea (Convolvulaceae) em caprinos no semiárido de Pernambuco

Cited by 10 publications

References 14 publications

Detection of swainsonine and calystegines in Convolvulaceae species from the semiarid region of Pernambuco

Detection of swainsonine and calystegines in Convolvulaceae species from the semiarid region of Pernambuco

Neurological diseases in cattle caused by plants and mycotoxins in Santa Catarina state, Brazil

Spontaneous and experimental poisoning by Merremia macrocalyx (Convolvulaceae) in cattle

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