Assessment of the electrocardiogram in dogs with visceral leishmaniasis

Sousa, Marlos Gonçalves; Carareto, Roberta; Silva, Jeanna G.; Oliveira, Juliana Ghisleni de

doi:10.1590/s0100-736x2013000500015

Cited by 6 publications

(16 citation statements)

References 7 publications

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“…This phenomenon was also observed in 14.3% of the 105 dogs with VL that were evaluated by Sousa et al (2013). First-degree atrioventricular block (Torrent et al, 2005), right bundle branch block and premature atrial contractions (Sousa et al, 2013) were also detected in dogs with VL, which diverges from the findings of the present study. Although sinus arrest is considered a physiological rhythm in some dogs, it may be associated with increased vagal tone, electrolyte imbalance, cervical neoplasia and pathologies involving the region of the atrial sinus node (Tilley, 1992).…”

Section: Discussioncontrasting

confidence: 98%

“…However, lower P wave amplitude is not a constant finding in studies involving dogs with VL, which reported suppression of R wave millivoltage (López-Peña et al, 2009) and longer duration of the P wave and QRS complex (Sousa et al, 2013). In the present study, all electrocardiographic variables remained within normal range for the species, but the differences between the CG and VLG groups suggest that atrial lesions may result in a decrease in P wave amplitude.…”

Section: Discussioncontrasting

confidence: 57%

“…However, the electrocardiographic assessment of 105 dogs with VL demonstrated the occurrence of sinus arrest (14.3%), premature atrial complexes (4.8%) and right bundle branch block (4.8%) (Sousa et al, 2013), which suggests the possible influence of myocarditis on these parameters. Likewise, the suppression of R wave millivoltage associated with atrophy and the degeneration of cardiomyocytes was reported in a dog with VL (López-Peña et al, 2009), as was first degree atrioventricular block and ST segment depression accompanied by myocarditis and necrotizing polyarteritis of the right atrium (Torrent et al, 2005).…”

Section: Introductionmentioning

confidence: 98%

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Clinical and histopathological features of myocarditis in dogs with visceral leishmaniasis

Santos

Pascon

Pereira

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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Visceral leishmaniasis (VL) is a cosmopolitan parasitic zoonosis that can promote myocarditis and heart rate changes in canine and human hosts. Thus, histopathological aspects of the myocardium and clinical, hematological, biochemical, radiological and electrocardiographic data were evaluated in a group of 36 dogs naturally infected with VL (VLG) and compared to data from 15 non-infected dogs (CG=Control Group). A prevalence of asymptomatic dogs was present in the CG (100%) and polysymptomatic dogs in the VLG (66%). In addition, two dogs in the VLG demonstrated systolic murmurs in the mitral valve region: one with a II/VI intensity and the other with a III/VI intensity. The mean values of RBC, hemoglobin and hematocrit were lower in dogs in VLG and were associated with higher values of total protein, total leukocytes, neutrophils, creatine kinase overall (CK) and the CK-MB fraction (CK-MB). The absence of radiographic changes was accompanied by a predominance of respiratory sinus arrhythmia associated with episodes of migratory pacemaker and sinus arrest in dogs in VLG (75%), sinus rhythm in dogs in CG (60%) and decreased P wave amplitude in VLG electrocardiography. Mononuclear cell infiltration was detected in the myocardium of 77,8% of dogs in GVL and classified primarily as mild multifocal lymphohistioplasmacytic. Amastigotes were detected in only one dog, which did not allow the association between myocarditis and parasitism, although the myocardial lesions that were found constitute irrefutable evidence of myocarditis in the VLG dogs, accompanied by lenient electrocardiographic changes compared to CG. Keywords: Electrocardiography, Leishmania sp., visceral leishmaniasis, dogs RESUMO A leishmaniose visceral (LV) é uma zoonose parasitária cosmopolita capaz de promover miocardite e alterações no ritmo cardíaco em cães e seres humanos. Dessa forma, os aspectos clínicos, hematimétricos, bioquímicos, radiográficos, eletrocardiográficos e histopatológicos do miocárdio foram avaliados em 36 cães naturalmente infectados com LV (GLV) e comparados a 15 cães não infectados (GC). Houve predomínio de cães assintomáticos no GC (100%) e polissintomáticos no GLV (66%). Dois cães do GLV apresentaram sopro sistólico de intensidade II/VI e III/VI, em região de foco mitral. Os valores médios de hemácia, hemoglobina e hematócrito foram inferiores nos cães do GLV, associados a maiores valores de proteína total, leucócitos totais, neutrófilos, creatinina quinase total (CK) e fração MB (CK-MB

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Section: Discussioncontrasting

confidence: 98%

Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 98%

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Clinical and histopathological features of myocarditis in dogs with visceral leishmaniasis

Santos

Pascon

Pereira

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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“…O envolvimento miocárdico, após quadros infecciosos, inclusive a LV, resulta no desenvolvimento de transtornos elétricos (Souza et al, 2008;Diamantino, 2010;Sousa et al, 2013). Durante a avaliação eletrocardiográfica, 29,3% dos animais do estudo apresentaram distúrbios de condução, com maior frequência de complexos de baixa voltagem, relatados em processos inflamatórios do tecido cardíaco (Pinto et al, 2008).…”

Section: Discussionunclassified

“…Durante a avaliação eletrocardiográfica, 29,3% dos animais do estudo apresentaram distúrbios de condução, com maior frequência de complexos de baixa voltagem, relatados em processos inflamatórios do tecido cardíaco (Pinto et al, 2008). No entanto, esses achados diferem das alterações observadas em cães com LV e complementam a lista de desordens eletrocardiográficas inespecíficas que podem ser identificadas em enfermidades infecciosas com envolvimento miocárdico (Sousa et al, 2013). O aumento da duração da onda P e do complexo QRS, detectado nos cães estudados, pode indicar tanto o aumento de átrio esquerdo e dos ventrículos quanto a presença de miocardiofibrose, que provocam uma lentidão na condução elétrica (Souza et al, 2008).…”

Section: Discussionunclassified

Avaliação dos indicadores de lesão miocárdica em cães com leishmaniose visceral

Godoy

Braz

Assis

et al. 2016

Arq. Bras. Med. Vet. Zootec.

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RESUMOO objetivo deste estudo foi avaliar os indicadores laboratoriais, eletrocardiográficos e histológicos de lesão cardíaca em diferentes grupos clínicos de cães com leishmaniose visceral. Foram analisados marcadores séricos, traçado eletrocardiográfico e fragmentos de tecido cardíaco de 41 cães naturalmente infectados, distribuídos em três grupos: assintomático, oligossintomático e sintomático. Todos os animais apresentaram aumento na atividade sérica da enzima creatina quinase fração MB. No traçado eletrocardiográfico, o complexo de baixa voltagem foi o distúrbio de condução mais frequente (8/10). Na análise histológica, 75,6% dos cães apresentaram reação inflamatória com predomínio de infiltrados linfo-histiocítico (13/31) de intensidade discreta a moderada e distribuição multifocal. As alterações microscópicas identificadas no miocárdio foram independentes dos achados laboratoriais, eletrocardiográficos e do quadro clínico apresentado pelos animais estudados. A ausência de associação entre alterações histopatológicas e os parâmetros investigados alerta para a dificuldade de identificação de cardiopatia em cães com leishmaniose visceral e ressalta a importância de incluir a leishmaniose visceral no diagnóstico de patologias cardíacas principalmente em regiões endêmicas para o agente.Palavras-chave: cardiomiopatia, enzimas, Leishmania, marcadores bioquímicos, miocardite ABSTRACT The aim of this study was to evaluate the laboratory indicators, electrocardiographic and cardiac histological lesions in different clinical groups of dogs with visceral leishmaniasis. Serum markers were analyzed in conjunction with

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Evaluation of heart fatty acid‐binding protein as a biomarker for canine leishmaniosis

et al. 2023

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Background: Myocarditis frequently occurs in canine leishmaniosis (CanL). Heart fatty acid-binding protein (HFABP) is a biomarker of myocardial damage. Methods: This study aimed to compare HFABP concentration (HFABPc) in healthy dogs and dogs at different stages of CanL and evaluate the correlation of this biomarker with several clinicopathological and echocardiographic variables. Thirty-one dogs diagnosed with CanL and 10 healthy dogs were included. Results: HFABPc was not statistically different (p > 0.05) between groups of dogs at different LeishVet stages of CanL or between groups with high versus low to intermediate serology titres. In 70% of CanL dogs, HFABPc was within the 95% confidence interval limits of the mean of healthy dogs. A moderate negative correlation with globulin (r = −0.519; p = 0.03) and haematocrit (HCT) (r = −0.538; p = 0.02) was observed. No other significant correlation (p > 0.05) was observed with any other variable. Limitations: Many statistical tests were performed, and therefore, type I error cannot be ruled out. Conclusion: HFABPc is not consistently elevated in dogs with CanL and is not associated with the severity of the disease, or most echocardiographic or clinicopathological variables studied. The correlation with globulin and HCT was not strong and not considered clinically significant. HFABPc lacks sufficient predictive capacity in dogs with CanL, discouraging further research or clinical use of this biomarker in this disease.

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Assessment of the electrocardiogram in dogs with visceral leishmaniasis

Cited by 6 publications

References 7 publications

Clinical and histopathological features of myocarditis in dogs with visceral leishmaniasis

Clinical and histopathological features of myocarditis in dogs with visceral leishmaniasis

Avaliação dos indicadores de lesão miocárdica em cães com leishmaniose visceral

Evaluation of heart fatty acid‐binding protein as a biomarker for canine leishmaniosis

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