Resposta imunológica em caprinos vacinados contra agalaxia contagiosa

Alcântara, Maria Dalva Bezerra de; Campos, Ana Cláudia; Melo, Márcia Almeida de; Filho, José Morais Pereira; Nascimento, Elmiro Rosendo do; Farias, Aderaldo A.; Sousa, Dalana R.M.; Azevedo, Edisio Oliveira de

doi:10.1590/s0100-736x2013000500001

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Only animals from group Gov2 showed a statistically significant difference when compared to the rest of the vaccinated groups and to the control (P<0.05). Similar results to those described in this paper were described by Alcântara et al (2013) and Buonavoglia et al (2010) when they used an oily adjuvant on the vaccine. The Montanide IMS-2215-VG contains organic immunostimulant substances in its composition and this formulation has probably stimulated a more efficient immunological response.…”

Section: Resultssupporting

confidence: 92%

Efficiency of inactive vaccines against contagious agalactia in Brazil

Campos

Azevedo

Alcântara

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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This paper aims to evaluate the efficiency of three inactive vaccines against contagious agalactia prepared with samples of Mycoplasma agalactiae isolated in Brazil and different adjuvants. Vaccine 1 adsorbed with aluminum hydroxide was administered in 23 goats (Gc1) and 13 sheep (Gov1); vaccine 2 containing Montanide IMS-2215-VG was administered in 22 goats (Gc2) and 12 sheep (Gov2) and vaccine 3, containing Montanide Gel-01 was administered in 22 goats (Gc3) and 12 sheep (Gov3). All animals were negative for Ma at indirect ELISA and received two doses of 2mL each, subcutaneously, within a 21 day interval. Five animals from each species were used as control. Seventy-five days after the booster, four animals from each vaccinated group and two from the control group were challenged with 5mL of Ma culture containing 10 7 cfu/mL, orally and through immersion of the female's udder in lactation. The serological response was analyzed during vaccination days (0 and 21) and at 51, 81, 111, 141 and 171 days after vaccination. The collection and analysis of the challenged animals were conducted at the day of the challenge (D0) and 7, 14, 21, 28, 35, 42, 49 and 56 days after the challenge. The three vaccines induced the production of antibodies, having no significant statistical difference (p<0.05). Animals from groups Gc1, Gc2 and Gov2 developed higher levels of antibodies, with significant statistical difference compared to the other vaccinated group and control group (p<0.05). After the challenge, the animals from the control presented an increase in regional lymph nodes and conjunctivitis, mastitis and arthritis. In four vaccinated animals, discrete conjunctivitis and congestion of the episcleral veins was observed. It is concluded that vaccines 1 and 2 induced levels of protective antibodies in goats and sheep, sufficient for clinical protection of the animals submitted to the experimental infection, indicating its use on the prevention of contagious agalactia.Keywords: Mycoplasma agalactiae, goats, sheep, immunization, ELISA RESUMO Este trabalho tem como objetivo avaliar a eficácia de três vacinas inativadas contra agalaxia contagiosa, preparadas com amostra de Mycoplasma agalactiae isolada no Brasil e diferentes adjuvantes. A vacina 1, adsorvida com hidróxido de alumínio, foi administrada em 23 caprinos (Gc1) e 13 ovinos (Gov1); a vacina 2, contendo Montanide IMS-2215-VG, foi administrada em 22 caprinos (Gc2) e 12 ovinos (Gov2); e a vacina 3, contendo Montanide Gel-01 foi administrada em 22 caprinos (Gc3) e 12 ovinos (Gov3). Todos os animais eram negativos para

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Section: Resultssupporting

confidence: 92%

Efficiency of inactive vaccines against contagious agalactia in Brazil

Campos

Azevedo

Alcântara

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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“…Adicionalmente, verificou-se a relação do histórico de participações em feiras e a ocorrência exposições e surtos de micoplasmoses nesses estados.Mais recentemente foi descrito soro prevalência superior a 56% (307/544) para M. agalactiae em caprinos no estado da Paraíba Alcantara et al (2010),. estudaram caprinos em 20 propriedades da Paraíba, onde 65% delas(13)apresentaram animais com sinais clínicos de agalaxia contagiosa.…”

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<b>Detecção molecular de <i>Mollicutes </i>em caprinos do sudoeste da Bahia, Brasil</b>: um estudo transversal

Júnior¹,

Edgar²

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Agradeço a Deus por todas as bênçãos concedidas, a oportunidade de me tornar mestre e ao foco e dedicação que me concedeu para a realização desse projeto. Aos meus amados pais, Regis e Sylmara, exemplos de caráter e dedicação, pelo apoio incondicional, por acreditarem em meu potencial, e serem os pilares que me mantiveram firme e forte durante todo o percurso. Ao meu falecido tio Rogério, pela presença durante minha infância moldando meu caráter positivo e questionador, me ensinando entre outras coisas o respeito pela família. Aos meus falecidos avós, Wilma e Renato, pelo exemplo de positividade e fraternidade familiar, pela proteção e intercessão divina de meus pedidos junto a Deus. Aos meus avós, Ruth e Edgar, pelo carinho dedicado, por acreditarem mais em mim do que eu mesmo, pelos conselhos, ensinamentos e incentivo de sempre. A minha esposa, Thabata, pelos 13 anos de amor e carinho, por suportar as fases mais difíceis e ser meu norte, me dando o suporte emocional necessário, mas principalmente pelo companheirismo e dedicação a nosso relacionamento. Ao meu irmão Denis, parceiro de toda a vida, pelo incentivo, o ouvido nos dias de desabafo e as sessões de relaxamento nas aulas de Muay Thai. A minha família inteira, por todos os momentos de carinho, suporte e alegrias que formaram meu caráter e fizeram me tornar a pessoa que hoje sou. Ao meu orientador, Prof. Dr. Nilson Benites, por me aceitar como seu aluno e todos os ensinamentos e atenção dispensada. Palavras-chave: Micoplasmas. Mycoplasma conjunctivae. Epidemiologia. Caprinos.

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Mycoplasma agalactiae Vaccines: Current Status, Hurdles, and Opportunities Due to Advances in Pathogenicity Studies

Barbosa,

Sampaio,

Spergser

et al. 2024

Vaccines

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Contagious agalactia (CA) is a serious multietiological disease whose classic etiological agent is Mycoplasma agalactiae and which causes high morbidity and mortality rates in infected herds. CA is classified as a notifiable disease by the World Organization for Animal Health due to its significant worldwide economic impact on livestock, primarily involving goat and sheep farms. The emergence of atypical symptoms and strains of M. agalactiae in wildlife ungulates reestablishes its highly plastic genome and is also of great epidemiological significance. Antimicrobial therapy is the main form of control, although several factors, such as intrinsic antibiotic resistance and the selection of resistant strains, must be considered. Available vaccines are few and mostly inefficient. The virulence and pathogenicity mechanisms of M. agalactiae mainly rely on surface molecules that have direct contact with the host. Because of this, they are essential for the development of vaccines. This review highlights the currently available vaccines and their limitations and the development of new vaccine possibilities, especially considering the challenge of antigenic variation and dynamic genome in this microorganism.

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Resposta imunológica em caprinos vacinados contra agalaxia contagiosa

Cited by 3 publications

References 8 publications

Efficiency of inactive vaccines against contagious agalactia in Brazil

Efficiency of inactive vaccines against contagious agalactia in Brazil

<b>Detecção molecular de <i>Mollicutes </i>em caprinos do sudoeste da Bahia, Brasil</b>: um estudo transversal

Mycoplasma agalactiae Vaccines: Current Status, Hurdles, and Opportunities Due to Advances in Pathogenicity Studies

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