Intoxicação natural por Amaranthus spinosus (Amaranthaceae) em ovinos no Sudeste do Brasil

Peixoto, Paulo Vargas; Brust, Luis Armando Calvão; Brito, Marilene de Farias; França, Ticiana N.; Cunha, Bernardo; Andrade, Gisele Braziliano de

doi:10.1590/s0100-736x2003000400007

Cited by 17 publications

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“…Fragmentos de coração de 10 ovinos, provenientes do trabalho prévio intitulado "Intoxicação natural por Amaranthus spinosus (Amaranthaceae) em ovinos no sudeste do Brasil" (Peixoto et al 2003), sendo 8 fêmeas adultas e 2 fetos, intoxicados naturalmente por Amaranthus spinosus no ano de 1997 no município de Paraíba do Sul, no Estado do Rio de Janeiro, fixados em formalina a 10% e emblocados em parafina, foram submetidos à coloração pela Hematoxilina e Eosina (HE) e à tecnica de imuno-histoquímica com a utilização do anticorpo anti--troponina C. Como controle positivo, foi utilizado fragmento de coração de um ovino intoxicado por monensina.…”

Section: Methodsunclassified

“…são plantas nefrotóxicas popularmente conhecidas como "caruru". A principal alteração histopatológica, na intoxicação por estas plantas, está presente no rim, sob forma de nefrose tubular tóxica, porém em alguns casos pode haver alterações cardíacas relacionadas (Osweiler et al 1969, Takken & Connor 1984, Peixoto et al 2003, Tokarnia et al 2012.…”

Section: Introductionunclassified

“…Alterações no eletrocardiograma, compatíveis com quadros de hipercalemia, foram descritas em suínos intoxicados por Amaranthus retroflexus (Osweiler et al 1969) e lesões como degeneração e necrose de miócitos cardíacos em suínos intoxicados por A. caudatus (Takken & Connor 1984) e em ovinos intoxicados por A. spinosus (Peixoto et al 2003). No entanto, há dúvidas com relação às alterações cardíacas, que, na maioria dos casos, são incipientes ou não apresentam reação inflamatória, o que pode levar a erros de interpretação.…”

Section: Introductionunclassified

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Troponina C na detecção imuno-histoquímica de alterações regressivas precoces no miocárdio de ovinos naturalmente intoxicados por Amaranthus spinosus (Amaranthaceae)

et al. 2016

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ABSTRACT.-Costa S.Z.R., Peixoto P.V., Brust L.A.C., d' Avila M.S., Santos A.M., Driemeier D., Nogueira V. A. & França T.N. 2016. [Troponin C in the immunohistochemistry detection of early regressive changes in sheep myocardium naturally poisoned by Amaranthus spinosus (Amaranthaceae).] Troponina C na detecção imuno-histoquímica de alterações regressivas precoces no miocárdio de ovinos naturalmente intoxicados por Amaranthus spinosus (Amaranthaceae). Pesquisa Veterinária Brasileira 36(2):83-89. Curso de Pós-Graduação em Medicina Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, BR-465 Km 7, Seropédica, RJ 23890-000, Brazil. E-mail: samayzillmann@gmail.com Amaranthus spp. are nephrotoxic plants popularly known as "pigweed". In cases of poisoning by these plants, the main histopathological alteration is found in the kidneys as toxic tubular nephrosis; however, in some cases, there may be cardiac changes. ECG changes associated with hyperkalemia have been described in pigs poisoned by Amaranthus retroflexus. Degeneration and necrosis of myocytes have been described in pigs poisoned by A. caudatus and sheep poisoned by A. spinosus. There are doubts regarding cardiac changes, since in most cases they are incipient and don't exhibit inflammatory reaction, which can lead to misinterpretation. For this study, paraffin blocks with tissues from a poisoning outbreak by A. spinosus in southeastern Brazil were used. The objective of the study was to detect the presence of incipient regressive changes in the myocardium of sheep poisoned by A. spinosus using anti-troponin C antibody-based immunohistochemistry. Fragments of hearts from 8 adult sheep and 2 fetuses naturally poisoned by A. spinosus were used. In the immunohistochemistry evaluation of the 8 hearts from the adult sheep there were several groups of myocytes with significant decrease or absence of immunoreactivity for anti-troponin C antibody. In most cases, these same areas on Hematoxylin and Eosin (HE) staining exhibited changes that varied from mild cellular tumefaction to increased eosinophilia, as well as loss of striation, cell lysis and karyolysis, sometimes accompanied by inflammatory infiltrate. In four cases, it was possible to notice that several small groups of myocytes exhibited decreased immunoreactivity corresponding to cells with undetectable or very subtle alterations on HE staining. The hearts of both fetuses did not exhibit areas with loss or decreased immunoreactivity for the anti-troponin C antibody. The results of this immunohistochemical evaluation confirmed the presence of incipient regressive changes and confirmed the occurrence of well-established necrotic lesions in the myocardium of sheep poisoned by Amaranthus spinosus. There was correspondence between areas where immunostaining for troponin was absent and areas with the most marked lesions obser-1 Recebido em 24 de julho de 2015Aceito para publicação em 28 de novembro de 2015 Parte da Tese de Doutorado do primeiro autor.

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Troponina C na detecção imuno-histoquímica de alterações regressivas precoces no miocárdio de ovinos naturalmente intoxicados por Amaranthus spinosus (Amaranthaceae)

et al. 2016

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“…No estado do Rio de Janeiro só havia sido registrado um surto causado por planta nefrotóxica, isto é, por Amaranthus spinosus, em ovinos (Peixoto et al 2003).…”

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Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

et al. 2012

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Metternichia princeps, a tree that belongs to the Solanaceae family, occurs in the Atlantic Forest of Brazil, from the state of Rio de Janeiro to Bahia. In the county of Itaguaí, state of Rio de Janeiro, M. princeps was suspected to cause a lethal kidney disease in goats. The poisoning was experimentally reproduced in goats conϐirming the suspicion. Experiments were then performed in rabbits. Leaves of M. princeps were collected in the county of Itaguaí, where the poisoning in goats occurred. Eleven rabbits received the dried plant material, ten received the fresh plant and one rabbit served as control. The dehydrated leaves were ground and mixed with water. Initially the suspension was administered by stomach tube to nine rabbits and caused death of seven of them at doses from 0.125g/kg on. Two rabbits that got sick, but survived at doses of 0.0625g/kg and 0.125g/kg, received doses of 0.5 and 0.25g/kg respectively, two months later and died, indicating that no tolerance to the plant poisoning effects developed. Additionally the dried leaves administered six months after collection to two rabbits at doses of 0.5 and 1g/kg respectively, caused death only of the rabbit that received the dose of 1g/kg, indicating that the stored leaves lost toxicity. Fresh sprouts caused death in three of six rabbits at doses of 1.55g/kg to 3g/kg. Fresh mature leaves caused death in one of four rabbits at the dose of 2g/kg, what suggests that there is no difference in toxicity between mature leaves and sprouts. The dried leaves caused death of rabbits at smaller doses than fresh leaves, what can be explained by the way of administration of the plant; dried leaves were given within a few minutes, whilst fresh leaves were ingested during one or two days, a fact that may inϐluence absorption of the toxic principle. In all experiments with the dried and fresh leaves (sprouts and mature leaves) of M. princeps, liver and heart lesions predominated. The course of the poisoning was peracute to acute. The rabbits became apathetic with pale and cyanotic mucosae and cold ears; they fell down with struggling movements, vocalization and spaced breathing and died. At postmortem examination, the liver was pale with marked hepatic lobules; the other organs were congested and blood vessels were ingurgitated. The histopathological examination revealed as the more important changes in the liver, intense, especially centrilobular congestion, severe swelling of the hepatocytes, and foci of incipient necrosis of hepatocytes. In the heart, beside congestion, small groups of eosiophilic cardiac ϐibers, with nuclear picnosis and vacuolation were found. In the kidney, congestion and swelling of epithelial cells

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“…A intoxicação ocorre, também, em outras espécies animais como suínos pela ingestão de Amaranthus caudatus, A. viridis, A. quitensis e A. retroflexus, (Buck et al 1966, Kommers et al 1996 e em ovinos causada por A. spinosus (Peixoto et al 2003).…”

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Intoxicação espontânea por Amaranthus hybridus (Amaranthaceae) em bovinos no sul do Rio Grande do Sul

Stigger¹,

Marcolongo-Pereira²,

Adrien³

et al. 2013

Pesq. Vet. Bras.

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in southern Rio Grande do Sul, Brazil. The morbidity rate observed was 48.33%, the mortality rate was 41.66% and lethality rate was 86.20%. The diagnosis of A. hybridus poisoning was made based on the epidemiological data, clinical signs, macroscopic and histological lesions characteristic of intoxication by nephrotoxic plants and by the presence of large amounts of the plant in the area where cattle were placed. Invasion of Brachiaria sp. pasture by A. hybridus alerts for the possibility of the occurrence of poisoning not only in stubble areas with lack of forage. In the case reported here there was abundant forage availability in the area where the outbreak occurred. Favorable climatic conditions and fertile soil for planting pasture, probably favored the growth of this invasive species. RESUMO.-Descreve-se um surto de intoxicação por Amaranthus hybridus ocorrido em bovinos em fevereiro/março de 2013 na região sul do Rio Grande do Sul. A morbidade foi de 48,33%, a mortalidade de 41,66% e a letalidade 86,20%. O diagnóstico da intoxicação por A. hybridus foi baseado nos dados epidemiológicos, sinais clínicos, achados de necropsia e lesões histológicas características da intoxicação por plantas nefrotóxicas e pela presença da planta em grande quantidade na área onde estavam os bovinos.A invasão da pastagem de Brachiaria sp. pela planta alerta para a possibilidade da ocorrência da intoxicação não somente em áreas de resteva com carência de forragem, uma vez que no surto relatado neste trabalho havia abundante disponibilidade de forragem nas áreas onde os bovinos se intoxicaram. No presente caso provavelmente as boas condições climáticas e o solo fertilizado para a plantação da pastagem favoreceram o crescimento da invasora. TERMOS DE INDEXAÇÃO: Plantas tóxicas, caruru, Amaranthus hybridus, Amaranthaceae, plantas nefrotóxicas, intoxicação por plantas, bovinos.

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Intoxicação natural por Amaranthus spinosus (Amaranthaceae) em ovinos no Sudeste do Brasil

Cited by 17 publications

References 4 publications

Troponina C na detecção imuno-histoquímica de alterações regressivas precoces no miocárdio de ovinos naturalmente intoxicados por Amaranthus spinosus (Amaranthaceae)

Troponina C na detecção imuno-histoquímica de alterações regressivas precoces no miocárdio de ovinos naturalmente intoxicados por Amaranthus spinosus (Amaranthaceae)

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

Intoxicação espontânea por Amaranthus hybridus (Amaranthaceae) em bovinos no sul do Rio Grande do Sul

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